Q9HKM3 (PYRI_THEAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase regulatory chain

Gene names

Name:	pyrI
Ordered Locus Names:	Ta0574

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	151 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in allosteric regulation of aspartate carbamoyltransferase By similarity. HAMAP MF_00002
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00002
Subunit structure	Contains catalytic and regulatory chains.
Sequence similarities	Belongs to the pyrI family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	aspartate carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 151	151	Aspartate carbamoyltransferase regulatory chain HAMAP MF_00002		PRO_0000142345
Sites
	Metal binding	108	1	Zinc By similarity
	Metal binding	113	1	Zinc By similarity
	Metal binding	137	1	Zinc By similarity
	Metal binding	140	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9HKM3 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 5FD68245A22B7AF6	FASTA	151	17,141
	10 20 30 40 50 60 MEKTLRISKI RDGTVIDHVP SGKGIRVIGV LGVHEDVNYT VSLAIHVPSN KMGFKDVIKI 70 80 90 100 110 120 ENRFLDRNEL DMISLIAPNA TISIIKNYEI SEKFQVELPS RLIGVLKCKN QNCITNTREP 130 140 150 VESEFEIVSK HPLVIRCVYC ERTMGEKDIF T

References

[1]	"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445064 Genomic DNA. Translation: CAC11714.1.
RefSeq	NP_394048.1. NC_002578.1.
3D structure databases
ProteinModelPortal	Q9HKM3.
ModBase	Search...
Proteomic databases
PRIDE	Q9HKM3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1456164.
GenomeReviews	Gene locus Ta0574 in contig AL139299_GR.
KEGG	tac:Ta0574.
NMPDR	fig|273075.1.peg.570.
Phylogenomic databases
HOGENOM	HBG305327.
OMA	TVIDHIT.
PhylomeDB	Q9HKM3.
ProtClustDB	PRK00893.
Enzyme and pathway databases
BioCyc	TACI273075:TA0574-MONOMER.
Family and domain databases
HAMAP	MF_00002. Asp_carb_tr_reg. [Tree]
InterPro	IPR020545. Asp_carbamoyltransf_reg_N. IPR002801. Asp_carbamoylTrfase_reg. IPR020542. Asp_carbamoyltrfase_reg_C. [Graphical view]
Gene3D	G3DSA:2.30.30.20. PyrI. 1 hit. G3DSA:3.30.70.140. PyrI. 1 hit.
KO	K00610.
Pfam	PF01948. PyrI. 1 hit. PF02748. PyrI_C. 1 hit. [Graphical view]
ProDom	PD006194. Asp_carbamoylTrfase_reg. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF54893. Asp_carbamoylTrfase_reg. 1 hit. SSF57825. Asp_transf_reg_C. 1 hit.
TIGRFAMs	TIGR00240. ATCase_reg. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PYRI_THEAC

Accession

Primary (citable) accession number: Q9HKM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	March 1, 2001
Last modified:	December 14, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program