Q9HKM2 (PYRB_THEAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Ta0575

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Subunit structure	Heterooligomer of catalytic and regulatory chains.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113261

Sequences

	Sequence		Length	Mass (Da)
	Q9HKM2 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 9CD3D48571A7D718	FASTA	305	34,398
	10 20 30 40 50 60 MLKNRSVVSI EDVDIDDLND LFDLSDSMLK TIEKGGSTDL LRNRIMATLF YEPSTRTRLS 70 80 90 100 110 120 FESAMHRLGG SVITVSDVKT SSVAKGETLA DTIRMASSYS DIIVIRHPLE GAARLASKFA 130 140 150 160 170 180 NKPVINAGDG SGQHPTQTIL DLYTIKRETG SIDGKTITMV GDLRYGRTIH SLIIALSRFD 190 200 210 220 230 240 VRINLVSPQI LKLPEYVLTK IGDRSRIMEY DDLSKVIEDT DVLYVTRIQK ERFSDQNEYQ 250 260 270 280 290 300 SVIGSYSVDR DLVSRMKKDA IIMHPLPRID EIKPEVDELP QARYFKQAYY GVPVRMALIY RILGD

References

[1]	"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445064 Genomic DNA. Translation: CAC11715.1.
RefSeq	NP_394049.1. NC_002578.1.
3D structure databases
ProteinModelPortal	Q9HKM2.
SMR	Q9HKM2. Positions 2-305.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1456165.
GenomeReviews	Gene locus Ta0575 in contig AL139299_GR.
KEGG	tac:Ta0575.
NMPDR	fig|273075.1.peg.571.
Phylogenomic databases
HOGENOM	HBG579429.
OMA	FKQSFYG.
PhylomeDB	Q9HKM2.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	TACI273075:TA0575-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_THEAC

Accession

Primary (citable) accession number: Q9HKM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	March 1, 2001
Last modified:	December 14, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program