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Q9HKK0 (DCD_THEAC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable deoxycytidine triphosphate deaminase

Short name=dCTP deaminase
EC=3.5.4.13
Gene names
Name:dcd
Ordered Locus Names:Ta0598
OrganismThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) [Reference proteome] [HAMAP]
Taxonomic identifier273075 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length166 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

dCTP + H2O = dUTP + NH3. HAMAP-Rule MF_00146

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP-Rule MF_00146

Sequence similarities

Belongs to the dCTP deaminase family.

Sequence caution

The sequence CAC11737.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processNucleotide metabolism
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

dUTP biosynthetic process

Inferred from electronic annotation. Source: InterPro

pyrimidine ribonucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functiondCTP deaminase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 166166Probable deoxycytidine triphosphate deaminase HAMAP-Rule MF_00146
PRO_0000156042

Sequences

Sequence LengthMass (Da)Tools
Q9HKK0 [UniParc].

Last modified March 27, 2002. Version 2.
Checksum: 1F4C9467CA3BFBD8

FASTA16618,293
        10         20         30         40         50         60 
MILNDSTIMR MVSDGLLISE NFDRGCLTPN GYDLRVDAID VEGRQYSEFE IGKNVHFLVS 

        70         80         90        100        110        120 
TIEILKIPDD VVGMIWTRSS FARKGIFGSF GAIDAGYHGN LTLSFFNAGS AVNLRRGERI 

       130        140        150        160 
AQIVFVKMIG SAEKPYHIRS GNYQNSRGIV KDPVAGSQIA SEAKKN 

« Hide

References

[1]"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL445064 Genomic DNA. Translation: CAC11737.1. Different initiation.
RefSeqNP_394071.1. NC_002578.1.

3D structure databases

ProteinModelPortalQ9HKK0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273075.Ta0598m.

Proteomic databases

PRIDEQ9HKK0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC11737; CAC11737; CAC11737.
GeneID1457022.
KEGGtac:Ta0598m.

Phylogenomic databases

eggNOGCOG0717.
KOK01494.
OMANDSTIMR.
ProtClustDBPRK00416.

Enzyme and pathway databases

UniPathwayUPA00610; UER00665.

Family and domain databases

HAMAPMF_00146. dCTP_deaminase.
InterProIPR011962. dCTP_deam.
IPR008180. dUTP_pyroPase.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR02274. dCTP_deam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDCD_THEAC
AccessionPrimary (citable) accession number: Q9HKK0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 27, 2002
Last modified: February 19, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways