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Protein

Probable dCTP deaminase

Gene

dcd

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable dCTP deaminase (dcd)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:Ta0598
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560421 – 166Probable dCTP deaminaseAdd BLAST166

Proteomic databases

PRIDEiQ9HKK0.

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta0598m.

Structurei

3D structure databases

ProteinModelPortaliQ9HKK0.
SMRiQ9HKK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04048. Archaea.
COG0717. LUCA.
OMAiEGILTMG.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR033704. dUTPase_trimeric.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HKK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILNDSTIMR MVSDGLLISE NFDRGCLTPN GYDLRVDAID VEGRQYSEFE
60 70 80 90 100
IGKNVHFLVS TIEILKIPDD VVGMIWTRSS FARKGIFGSF GAIDAGYHGN
110 120 130 140 150
LTLSFFNAGS AVNLRRGERI AQIVFVKMIG SAEKPYHIRS GNYQNSRGIV
160
KDPVAGSQIA SEAKKN
Length:166
Mass (Da):18,293
Last modified:March 27, 2002 - v2
Checksum:i1F4C9467CA3BFBD8
GO

Sequence cautioni

The sequence CAC11737 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445064 Genomic DNA. Translation: CAC11737.1. Different initiation.
RefSeqiWP_010901022.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC11737; CAC11737; CAC11737.
GeneIDi1457022.
KEGGitac:Ta0598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445064 Genomic DNA. Translation: CAC11737.1. Different initiation.
RefSeqiWP_010901022.1. NC_002578.1.

3D structure databases

ProteinModelPortaliQ9HKK0.
SMRiQ9HKK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273075.Ta0598m.

Proteomic databases

PRIDEiQ9HKK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC11737; CAC11737; CAC11737.
GeneIDi1457022.
KEGGitac:Ta0598.

Phylogenomic databases

eggNOGiarCOG04048. Archaea.
COG0717. LUCA.
OMAiEGILTMG.

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR033704. dUTPase_trimeric.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCD_THEAC
AccessioniPrimary (citable) accession number: Q9HKK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 27, 2002
Last modified: November 30, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.