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Protein

Probable transaldolase

Gene

tal

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.By similarity

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable transaldolase (tal)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86Schiff-base intermediate with substrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pentose shunt

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00115; UER00414.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transaldolase (EC:2.2.1.2)
Gene namesi
Name:tal
Ordered Locus Names:Ta0616
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001736911 – 223Probable transaldolaseAdd BLAST223

Proteomic databases

PRIDEiQ9HKI3.

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta0616.

Structurei

Secondary structure

1223
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Helixi10 – 19Combined sources10
Beta strandi24 – 26Combined sources3
Helixi29 – 35Combined sources7
Helixi42 – 52Combined sources11
Beta strandi57 – 60Combined sources4
Helixi66 – 78Combined sources13
Beta strandi83 – 90Combined sources8
Helixi91 – 102Combined sources12
Beta strandi107 – 112Combined sources6
Helixi115 – 123Combined sources9
Beta strandi127 – 133Combined sources7
Helixi134 – 138Combined sources5
Helixi144 – 156Combined sources13
Beta strandi161 – 167Combined sources7
Helixi171 – 180Combined sources10
Beta strandi183 – 187Combined sources5
Helixi189 – 194Combined sources6
Helixi199 – 215Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S0CX-ray1.78A/B/C/D/E1-223[»]
3S1UX-ray1.90A/B/C/D/E1-223[»]
3S1VX-ray1.80A/B/C/D/E1-223[»]
3S1WX-ray1.80A/B/C/D/E1-223[»]
3S1XX-ray1.65A/B/C/D/E1-223[»]
4XZ9X-ray1.80A/B/C/D/E1-223[»]
ProteinModelPortaliQ9HKI3.
SMRiQ9HKI3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HKI3.

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 3B subfamily.Curated

Phylogenomic databases

eggNOGiarCOG05061. Archaea.
COG0176. LUCA.
HOGENOMiHOG000226073.
KOiK00616.
OMAiVRHPMHV.

Family and domain databases

CDDicd00956. Transaldolase_FSA. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00494. Transaldolase_3b. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR022999. Transaldolase_3B.
IPR004731. Transaldolase_3B/F6P_aldolase.
IPR018225. Transaldolase_AS.
IPR033919. TSA/FSA_arc/bac.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. TAL_FSA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00875. fsa_talC_mipB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HKI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIFLDTANI DEIRTGVNWG IVDGVTTNPT LISKEAVNGK KYGDIIREIL
60 70 80 90 100
KIVDGPVSVE VVSTKYEGMV EEARKIHGLG DNAVVKIPMT EDGLRAIKTL
110 120 130 140 150
SSEHINTNCT LVFNPIQALL AAKAGATYVS PFVGRLDDIG EDGMQIIDMI
160 170 180 190 200
RTIFNNYIIK TQILVASIRN PIHVLRSAVI GADVVTVPFN VLKSLMKHPK
210 220
TDEGLAKFLE DWKKVSPDGK LIL
Length:223
Mass (Da):24,437
Last modified:March 1, 2001 - v1
Checksum:iA81C5F74B856E736
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445064 Genomic DNA. Translation: CAC11755.1.
RefSeqiWP_010901039.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC11755; CAC11755; CAC11755.
GeneIDi1456197.
KEGGitac:Ta0616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445064 Genomic DNA. Translation: CAC11755.1.
RefSeqiWP_010901039.1. NC_002578.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S0CX-ray1.78A/B/C/D/E1-223[»]
3S1UX-ray1.90A/B/C/D/E1-223[»]
3S1VX-ray1.80A/B/C/D/E1-223[»]
3S1WX-ray1.80A/B/C/D/E1-223[»]
3S1XX-ray1.65A/B/C/D/E1-223[»]
4XZ9X-ray1.80A/B/C/D/E1-223[»]
ProteinModelPortaliQ9HKI3.
SMRiQ9HKI3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273075.Ta0616.

Proteomic databases

PRIDEiQ9HKI3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC11755; CAC11755; CAC11755.
GeneIDi1456197.
KEGGitac:Ta0616.

Phylogenomic databases

eggNOGiarCOG05061. Archaea.
COG0176. LUCA.
HOGENOMiHOG000226073.
KOiK00616.
OMAiVRHPMHV.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00414.

Miscellaneous databases

EvolutionaryTraceiQ9HKI3.

Family and domain databases

CDDicd00956. Transaldolase_FSA. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00494. Transaldolase_3b. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR022999. Transaldolase_3B.
IPR004731. Transaldolase_3B/F6P_aldolase.
IPR018225. Transaldolase_AS.
IPR033919. TSA/FSA_arc/bac.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. TAL_FSA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00875. fsa_talC_mipB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAL_THEAC
AccessioniPrimary (citable) accession number: Q9HKI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.