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Q9HKF1

- ASSY_THEAC

UniProt

Q9HKF1 - ASSY_THEAC

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei83 – 831CitrullineUniRule annotation
Binding sitei113 – 1131ATP; via amide nitrogenUniRule annotation
Binding sitei115 – 1151AspartateUniRule annotation
Binding sitei119 – 1191AspartateUniRule annotation
Binding sitei119 – 1191CitrullineUniRule annotation
Binding sitei120 – 1201AspartateUniRule annotation
Binding sitei123 – 1231CitrullineUniRule annotation
Binding sitei169 – 1691CitrullineUniRule annotation
Binding sitei178 – 1781CitrullineUniRule annotation
Binding sitei253 – 2531CitrullineUniRule annotation
Binding sitei265 – 2651CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 159ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Ta0650
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001024: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Argininosuccinate synthasePRO_0000148688Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi273075.Ta0650.

Structurei

3D structure databases

ProteinModelPortaliQ9HKF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HKF1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKALLLYSG GLDTSVMIKW IQENLSMDVA TLTLNVGNSD LVAIEEKARM
60 70 80 90 100
LGADPVFVHD AKDEFAEKFI AKSIMANGSY EGYPLSTALA RPLMAEKAVK
110 120 130 140 150
YAQKIGAKYI VHGSTGRGND QVRFEVSIRA LDPSMQVLVP VREWNMMRKD
160 170 180 190 200
EVEYAKTHGI PVKLDGKYSI DENIWGRSVE GPDLEDIGKG VPEDVYEWVV
210 220 230 240 250
PPWKANAEHT LKIAFDGGIP SEIDGEKMKL ADLIVFLNTL AGSSGIGLID
260 270 280 290 300
HMENRVVGLK SHEVYECPAA TVITHAHRYL ESLILNRNEA EVKMNMDWQF
310 320 330 340 350
AKFVYGGLWH DPVMNAVNAA EAEFNRDISG EIKIRMSHGI MYIEGAWGNS
360 370 380 390 400
FLYSKDLINY SSMAFDQRAS KGFIDIYGNA TVHSHNRNPK MVKEVQGSSV

EF
Length:402
Mass (Da):44,813
Last modified:December 12, 2006 - v2
Checksum:iC0A76320E885B537
GO

Sequence cautioni

The sequence CAC11788.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445065 Genomic DNA. Translation: CAC11788.1. Different initiation.
RefSeqiNP_394121.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC11788; CAC11788; CAC11788.
GeneIDi1456223.
KEGGitac:Ta0650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445065 Genomic DNA. Translation: CAC11788.1 . Different initiation.
RefSeqi NP_394121.1. NC_002578.1.

3D structure databases

ProteinModelPortali Q9HKF1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273075.Ta0650.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC11788 ; CAC11788 ; CAC11788 .
GeneIDi 1456223.
KEGGi tac:Ta0650.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
    Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
    Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Entry informationi

Entry nameiASSY_THEAC
AccessioniPrimary (citable) accession number: Q9HKF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3