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Q9HKF1

- ASSY_THEAC

UniProt

Q9HKF1 - ASSY_THEAC

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Protein
Argininosuccinate synthase
Gene
argG, Ta0650
Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei83 – 831Citrulline By similarity
Binding sitei113 – 1131ATP; via amide nitrogen By similarity
Binding sitei115 – 1151Aspartate By similarity
Binding sitei119 – 1191Aspartate By similarity
Binding sitei119 – 1191Citrulline By similarity
Binding sitei120 – 1201Aspartate By similarity
Binding sitei123 – 1231Citrulline By similarity
Binding sitei169 – 1691Citrulline By similarity
Binding sitei178 – 1781Citrulline By similarity
Binding sitei253 – 2531Citrulline By similarity
Binding sitei265 – 2651Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 159ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Ta0650
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001024: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Argininosuccinate synthaseUniRule annotation
PRO_0000148688Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi273075.Ta0650.

Structurei

3D structure databases

ProteinModelPortaliQ9HKF1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HKF1-1 [UniParc]FASTAAdd to Basket

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MDKALLLYSG GLDTSVMIKW IQENLSMDVA TLTLNVGNSD LVAIEEKARM    50
LGADPVFVHD AKDEFAEKFI AKSIMANGSY EGYPLSTALA RPLMAEKAVK 100
YAQKIGAKYI VHGSTGRGND QVRFEVSIRA LDPSMQVLVP VREWNMMRKD 150
EVEYAKTHGI PVKLDGKYSI DENIWGRSVE GPDLEDIGKG VPEDVYEWVV 200
PPWKANAEHT LKIAFDGGIP SEIDGEKMKL ADLIVFLNTL AGSSGIGLID 250
HMENRVVGLK SHEVYECPAA TVITHAHRYL ESLILNRNEA EVKMNMDWQF 300
AKFVYGGLWH DPVMNAVNAA EAEFNRDISG EIKIRMSHGI MYIEGAWGNS 350
FLYSKDLINY SSMAFDQRAS KGFIDIYGNA TVHSHNRNPK MVKEVQGSSV 400
EF 402
Length:402
Mass (Da):44,813
Last modified:December 12, 2006 - v2
Checksum:iC0A76320E885B537
GO

Sequence cautioni

The sequence CAC11788.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445065 Genomic DNA. Translation: CAC11788.1. Different initiation.
RefSeqiNP_394121.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC11788; CAC11788; CAC11788.
GeneIDi1456223.
KEGGitac:Ta0650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445065 Genomic DNA. Translation: CAC11788.1 . Different initiation.
RefSeqi NP_394121.1. NC_002578.1.

3D structure databases

ProteinModelPortali Q9HKF1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 273075.Ta0650.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC11788 ; CAC11788 ; CAC11788 .
GeneIDi 1456223.
KEGGi tac:Ta0650.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
    Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
    Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Entry informationi

Entry nameiASSY_THEAC
AccessioniPrimary (citable) accession number: Q9HKF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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