Q9HKE4 (CBIT_THEAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cobalt-precorrin-6Y C(15)-methyltransferase [decarboxylating]
EC=2.1.1.-

Gene names

Name:	cbiT
Ordered Locus Names:	Ta0657

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probably catalyzes the methylation of either C-15 or C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W. Methylation of C-15 would probably be followed by a spontaneous decarboxylation of C-12 By similarity. HAMAP MF_00786
Pathway	Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 8/10. HAMAP MF_00786
Sequence similarities	Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.

Ontologies

Keywords
Biological process	Cobalamin biosynthesis
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cobalamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein methyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	Probable cobalt-precorrin-6Y C(15)-methyltransferase [decarboxylating] HAMAP MF_00786		PRO_0000134946
Regions
	Region	53 – 57	5	S-adenosyl-L-methionine binding By similarity
Sites
	Binding site	29	1	S-adenosyl-L-methionine By similarity
	Binding site	77	1	S-adenosyl-L-methionine By similarity
	Binding site	106	1	S-adenosyl-L-methionine; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9HKE4 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: E9474269A18CB97C	FASTA	202	22,628
	10 20 30 40 50 60 MRMEGENWVY EVRGIPDEFF QRSEGIPMTK REIRIISLSD LRIRPGMRVM DIGCGSGSMT 70 80 90 100 110 120 VEISNIIGEN GSVTGLDVSG EAADLTMRNC RNLCRFSNYR IVISDVYKYD SDEEFDAVFV 130 140 150 160 170 180 GGGTARIHDL FERIERMVHH ASRVVVNAIQ IHTAYLSLEE MNTRGYSGVN ITQVMVSNGM 190 200 RTSEGYAMIA RNPVFIISGD AP

References

[1]

"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445065 Genomic DNA. Translation: CAC11795.1.
RefSeq	NP_394128.1. NC_002578.1.
3D structure databases
ProteinModelPortal	Q9HKE4.
ModBase	Search...
Proteomic databases
PRIDE	Q9HKE4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1456230.
GenomeReviews	Gene locus Ta0657 in contig AL139299_GR.
KEGG	tac:Ta0657.
NMPDR	fig|273075.1.peg.650.
Phylogenomic databases
HOGENOM	HBG553505.
OMA	MLARNTI.
Enzyme and pathway databases
BioCyc	TACI273075:TA0657-MONOMER.
Family and domain databases
HAMAP	MF_00786. CbiT. [Tree]
InterPro	IPR014008. Cbl_synth_MTase_CbiT. IPR023475. Cbl_synth_MTase_CbiT_arc-type. [Graphical view]
KO	K02191.
TIGRFAMs	TIGR02469. CbiT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CBIT_THEAC

Accession

Primary (citable) accession number: Q9HKE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	March 1, 2001
Last modified:	November 16, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program