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Q9HK31

- SYL_THEAC

UniProt

Q9HK31 - SYL_THEAC

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Protein

Leucine--tRNA ligase

Gene
leuS, Ta0777
Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei614 – 6141ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Ta0777
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001024: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 910910Leucine--tRNA ligaseUniRule annotationPRO_0000152148Add
BLAST

Proteomic databases

PRIDEiQ9HK31.

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta0777.

Structurei

3D structure databases

ProteinModelPortaliQ9HK31.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi50 – 6011"HIGH" regionUniRule annotationAdd
BLAST
Motifi611 – 6155"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiYSKFVEW.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HK31-1 [UniParc]FASTAAdd to Basket

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MDDRGRRCCT HSGVIALDIE AKWQNAWDRD GIFVPKMDGR KKFMITVPWP    50
YTNGSLHVGH GRTYTLGDII ARYKRSRNYN VLFPMGFHQS GTPILAFSER 100
IRAGDRSTID LYTSYLKEYG EKDIDALIES FKDPKNIADY FSNAIINDFK 150
HLGYSIDWTR RFTSADEFYQ KFVQWQFRRL NEKGLVKQGR YPILYSLEDD 200
NAVGEDDIKD GDTDKVTIEE YTAIFFRGKS FDLIAASLRP ETIYGITNIW 250
VNPDVKYVKV KISGRMAVVS EECSTKLKFQ GNEIEVAGEA SVQEIQKQTY 300
TTPAGKEVKV YQADFVDPDN GTGIVYSVPS HSVYDYVYYR KKRGKDFPVI 350
IEAPMKMKDI ESKYDLETEE GREEATKDLY RNEFYYGKLV DSGPYTGMTV 400
REAREAVKRD LISSGNAFTF YETSRHAVTR SGSKVIVAVL PDQWFLDYSQ 450
PWLKDLGHTM INTMTMHPEV YRNVMNDAID WLKERPCARR RGLGTRLPFD 500
DRWVIESLSD STIYPAVYTN SIPLRSLYET GKLDDDAITR IFMNGEPKNE 550
DESEAKRQFE YWYPVDIRLT AIPHISNHLS FYVLNHAAIF PKEKWPAGLI 600
ISGLVVSNGA KISKSKGNVV SLLEIAKKYS ADIYRLYVAV QADISSTMDW 650
NETDLASITR RFNEFKDLMA GFKQDTSDLT FEEAWFVARF SVRLRQFMES 700
MDRYQIRDAY INIFYGVLND LRYLSSRGGD VNRALTPVIA DWLRALMPVI 750
PHHAEEYWHS YVSDTYVSVD PFDENFQDRY ERTVRRFGMT CDQMYSAMDY 800
VEKVLQDVKN IMQVTGIEPK SVEITVANAD VVRAAQEFLN NSVSGQSKKY 850
MQYLAKRRKD IMIYGFDEYD VLQRNQVYLS KQIGCPVRIE RGDVINGKIA 900
LPGKPVIYIS 910
Length:910
Mass (Da):105,028
Last modified:March 1, 2001 - v1
Checksum:i17FA01BB946DF0BE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445065 Genomic DNA. Translation: CAC11908.1.
RefSeqiNP_394239.1. NC_002578.1.
WP_010901190.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC11908; CAC11908; CAC11908.
GeneIDi1456331.
KEGGitac:Ta0777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445065 Genomic DNA. Translation: CAC11908.1 .
RefSeqi NP_394239.1. NC_002578.1.
WP_010901190.1. NC_002578.1.

3D structure databases

ProteinModelPortali Q9HK31.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273075.Ta0777.

Proteomic databases

PRIDEi Q9HK31.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC11908 ; CAC11908 ; CAC11908 .
GeneIDi 1456331.
KEGGi tac:Ta0777.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi YSKFVEW.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
    Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
    Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Entry informationi

Entry nameiSYL_THEAC
AccessioniPrimary (citable) accession number: Q9HK31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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