Reviewed, UniProtKB/Swiss-Prot Q9HK30 (PDAD_THEAC)

Names and origin

Protein names

Recommended name:
    Pyruvoyl-dependent arginine decarboxylase
      Short name=PvlArgDC
    EC=4.1.1.19
Cleaved into the following 2 chains:
    1- Recommended name:
            Pyruvoyl-dependent arginine decarboxylase subunit beta
    2- Recommended name:
            Pyruvoyl-dependent arginine decarboxylase subunit alpha

Gene names

Name:	pdaD
Ordered Locus Names:	Ta0778

Organism

Thermoplasma acidophilum [Complete proteome] [HAMAP]

Taxonomic identifier

2303 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01404
Cofactor	Pyruvoyl group By similarity. HAMAP MF_01404
Sequence similarities	Belongs to the pdaD family.

Ontologies

Keywords
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 43	43	Pyruvoyl-dependent arginine decarboxylase subunit beta By similarity		PRO_0000023336
	Chain	44 – 182	139	Pyruvoyl-dependent arginine decarboxylase subunit alpha By similarity		PRO_0000023337
Sites
	Site	43 – 44	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	44	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9HK30-1 [UniParc]. Last modified July 11, 2002. Version 2. Checksum: 2053EE343EE41B89	FASTA	182	19,672
	10 20 30 40 50 60 MSGFVPTHIF FTRGVGRGET QLVSFEAALR DAGIAPYNLS SISSIFPPHA EMITREEGLK 70 80 90 100 110 120 KLSPGQILFT VLARNTSNEL NRMVSAAIGY AIPRDRSKWG YLSEHHSFGE TEKVAGSFAE 130 140 150 160 170 180 KLAAEMLAST IGSSAQLAYD KQKEEYVLED KILTTGSISS TAVVLESGEW TTVVAAAVLI VE

References

[1]

"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / AMRC-C165 / DSM 1728 / IFO 15155 / JCM 9062.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445065 Genomic DNA. Translation: CAC11909.1. Different initiation.
RefSeq	NP_394240.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1456332.
KEGG	tac:Ta0778.
NMPDR	fig|273075.1.peg.762.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG539680.
OMA	YKMSGKI.
Enzyme and pathway databases
BioCyc	TACI273075:TA0778-MONOMER.
BRENDA	4.1.1.19. 435.
Family and domain databases
HAMAP	MF_01404. PvlArgDC. [Tree]
InterPro	IPR016104. Pyr-dep_his/arg-deCO2ase. IPR016105. Pyr-dep_his/arg-deCO2ase_sand. IPR002724. Pyruvoyl-dep_arg_deCO2ase. [Graphical view]
Gene3D	G3DSA:3.50.20.10. Pyr-dep_his/arg-deCO2ase_sand. 1 hit.
Pfam	PF01862. PvlArgDC. 1 hit. [Graphical view]
PIRSF	PIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDom	PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00286. PvlArgDC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDAD_THEAC

Accession

Primary (citable) accession number: Q9HK30

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	July 11, 2002
Last modified:	February 9, 2010
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)