Q9HJV9 (GMHA_THEAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable phosphoheptose isomerase
EC=5.3.1.28

Alternative name(s):
Sedoheptulose 7-phosphate isomerase

Gene names

Name:	gmhA
Ordered Locus Names:	Ta0854

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity. HAMAP MF_00067
Catalytic activity	D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate. HAMAP MF_00067
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00067
Pathway	Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1. HAMAP MF_00067
Subcellular location	Cytoplasm By similarity HAMAP MF_00067.
Miscellaneous	The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity. HAMAP MF_00067
Sequence similarities	Belongs to the SIS family. GmhA subfamily. Contains 1 SIS domain.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	D-sedoheptulose 7-phosphate isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW sugar binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 182	182	Probable phosphoheptose isomerase HAMAP MF_00067		PRO_0000136553
Regions
	Domain	29 – 182	154	SIS
	Region	44 – 46	3	Substrate binding By similarity
	Region	86 – 87	2	Substrate binding By similarity
	Region	112 – 114	3	Substrate binding By similarity
Sites
	Metal binding	53	1	Zinc By similarity
	Metal binding	57	1	Zinc By similarity
	Metal binding	164	1	Zinc By similarity
	Metal binding	172	1	Zinc By similarity
	Binding site	57	1	Substrate By similarity
	Binding site	117	1	Substrate By similarity
	Binding site	164	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9HJV9 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 450404CB9DB7F818	FASTA	182	19,368
	10 20 30 40 50 60 MDAKKYLEEG ARARLNLNIE KIIGIADKIS SAISSGNKLI VFGNGGSAAD AQHFVAELTG 70 80 90 100 110 120 HFMKERKPLA AIALTTNTSS ITAIANDYSY DVVFSRQVEA LAKPGDVVVG ISTSGNSKNV 130 140 150 160 170 180 IEGIKSAKRI GCHTIAFTGR SGGQLKGVAD ETLNVDSDLT SIIQEMHITV IHMICAMIDE KF

References

[1]

"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445065 Genomic DNA. Translation: CAC11983.1.
RefSeq	NP_394313.1. NC_002578.1.
3D structure databases
ProteinModelPortal	Q9HJV9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1456395.
GenomeReviews	Gene locus Ta0854 in contig AL139299_GR.
KEGG	tac:Ta0854.
NMPDR	fig|273075.1.peg.835.
Phylogenomic databases
HOGENOM	HBG671955.
OMA	HITIIHI.
PhylomeDB	Q9HJV9.
ProtClustDB	PRK13937.
Enzyme and pathway databases
BioCyc	TACI273075:TA0854-MONOMER.
Family and domain databases
HAMAP	MF_00067. GmhA. [Tree]
InterPro	IPR020620. Phosphoheptose_isomerase. IPR001347. SIS. [Graphical view]
KO	K03271.
Pfam	PF01380. SIS. 1 hit. [Graphical view]
PROSITE	PS51464. SIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMHA_THEAC

Accession

Primary (citable) accession number: Q9HJV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	March 1, 2001
Last modified:	December 14, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program