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Protein

DNA polymerase sliding clamp

Gene

pcn

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

BioCyciTACI273075:G1GT7-1015-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clampUniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homologUniRule annotation
Short name:
PCNAUniRule annotation
Gene namesi
Name:pcnUniRule annotation
Ordered Locus Names:Ta0917
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492201 – 246DNA polymerase sliding clampAdd BLAST246

Proteomic databases

PRIDEiQ9HJQ0

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Protein-protein interaction databases

STRINGi273075.Ta0917

Structurei

3D structure databases

ProteinModelPortaliQ9HJQ0
SMRiQ9HJQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488 Archaea
COG0592 LUCA
HOGENOMiHOG000222371
KOiK04802
OMAiKCANSDD
OrthoDBiPOG093Z0814

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HJQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRLNLSVKN LKEITDLLST IVSEAKFRVD ENGMSVTAVD PAHVAMIRLE
60 70 80 90 100
VPKEAFVEFH TDGQEEIALD IDRLKSVIRL ASSSENVGIT KDGEKLKFEL
110 120 130 140 150
GTINKSISLL DPSTIVTPKI PNITSEYYAV LKKSDFERGL RAAEDISDSI
160 170 180 190 200
RFTLSQDGFK AYSHSESEES EMILPKDLIT DMSCNTTIKS SYPLEYLLKF
210 220 230 240
IKAISSTDSL KLSFRDDYPL SVEFYLDQNP GAKIKGLFLL APRMEQ
Length:246
Mass (Da):27,582
Last modified:February 21, 2001 - v1
Checksum:iAD42122CFF786C86
GO

Sequence cautioni

The sequence CAC12046 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445065 Genomic DNA Translation: CAC12046.1 Different initiation.
RefSeqiWP_052295741.1, NC_002578.1

Genome annotation databases

EnsemblBacteriaiCAC12046; CAC12046; CAC12046
GeneIDi1456452
KEGGitac:Ta0917

Similar proteinsi

Entry informationi

Entry nameiPCNA_THEAC
AccessioniPrimary (citable) accession number: Q9HJQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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