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Q9HJM5

- SYE_THEAC

UniProt

Q9HJM5 - SYE_THEAC

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (30 Apr 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:Ta0942
    OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
    Taxonomic identifieri273075 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
    ProteomesiUP000001024: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 548548Glutamate--tRNA ligasePRO_0000119733Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273075.Ta0942.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HJM5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi102 – 11211"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000073585.
    KOiK01885.
    OMAiYLGWDDP.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    2.40.240.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_A. Glu_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00463. gltX_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HJM5-1 [UniParc]FASTAAdd to Basket

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    MYEDDIRRIA LINAYQHEGK ADLKSVMGKV MAEIPDLRRD PRSAREMVSR    50
    IVDEVNSMSA YEIRETVETR YTSSIRKEKK VEEHRLPDLE GVNGPVVMRM 100
    APSPSGPLHI GHTRMAILND EYVKRYGGEL ILRIEDTNPK NIDPDAYHMI 150
    PEDLEWLGVN VTKIVIQSDR FDLYYAEAKK LMENGHMYVC TCPREEFKKR 200
    KLESIPCKDR DNPPETNLEL FDKMIDGTIK EGDAVAVVKT DLKHPNPSVR 250
    DWIAFRIIEA RHPRVDDKYR VYPMMSFSVA VDDHYLGLTH VLRGKDQLTN 300
    TDKQRYIFDY NGWKKPYYYH YGMIKFPGIK LKTSLMKKGI LSGQYEGWSD 350
    IRLGTVRAFA KRGYRPETFR RYWINSGLRE IDAIFSIEIF DSINREIVDP 400
    RAYRFSFVKD PVPVRIEGMP NISAKLPLHP THPEYGFREY EVKGSVYIAS 450
    RDFAAISEGE RIRLKDLCYI RKKGNGIIYD GVEMTEKTKI INWCPEGSRD 500
    FSVLKPDGSK DSGLIEPKSS GYRGIAQLER YGYVNFADGD DLAYFTHP 548
    Length:548
    Mass (Da):63,450
    Last modified:April 30, 2003 - v2
    Checksum:i1736628A27C73D60
    GO

    Sequence cautioni

    The sequence CAC12071.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445066 Genomic DNA. Translation: CAC12071.1. Different initiation.
    RefSeqiNP_394401.1. NC_002578.1.

    Genome annotation databases

    EnsemblBacteriaiCAC12071; CAC12071; CAC12071.
    GeneIDi1456475.
    KEGGitac:Ta0942.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445066 Genomic DNA. Translation: CAC12071.1 . Different initiation.
    RefSeqi NP_394401.1. NC_002578.1.

    3D structure databases

    ProteinModelPortali Q9HJM5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273075.Ta0942.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC12071 ; CAC12071 ; CAC12071 .
    GeneIDi 1456475.
    KEGGi tac:Ta0942.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000073585.
    KOi K01885.
    OMAi YLGWDDP.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    2.40.240.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_A. Glu_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
      Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
      Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

    Entry informationi

    Entry nameiSYE_THEAC
    AccessioniPrimary (citable) accession number: Q9HJM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: April 30, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3