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Protein

GMP synthase [glutamine-hydrolyzing] subunit A

Gene

guaAA

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the synthesis of GMP from XMP.UniRule annotation

Catalytic activityi

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.UniRule annotation

Pathwayi: GMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GMP from XMP (L-Gln route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GMP synthase [glutamine-hydrolyzing] subunit B (guaAB), GMP synthase [glutamine-hydrolyzing] subunit A (guaAA)
This subpathway is part of the pathway GMP biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GMP from XMP (L-Gln route), the pathway GMP biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei80 – 801NucleophileUniRule annotation
Active sitei167 – 1671UniRule annotation
Active sitei169 – 1691UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00189; UER00296.

Protein family/group databases

MEROPSiC26.A31.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP synthase [glutamine-hydrolyzing] subunit AUniRule annotation (EC:6.3.5.2UniRule annotation)
Alternative name(s):
Glutamine amidotransferaseUniRule annotation
Gene namesi
Name:guaAAUniRule annotation
Ordered Locus Names:Ta0944
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200GMP synthase [glutamine-hydrolyzing] subunit APRO_0000140235Add
BLAST

Interactioni

Subunit structurei

Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).UniRule annotation

Protein-protein interaction databases

STRINGi273075.Ta0944m.

Structurei

Secondary structure

1
200
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 108Combined sources
Helixi16 – 238Combined sources
Beta strandi30 – 323Combined sources
Helixi37 – 404Combined sources
Beta strandi44 – 485Combined sources
Helixi55 – 573Combined sources
Helixi59 – 613Combined sources
Helixi62 – 7110Combined sources
Beta strandi76 – 794Combined sources
Helixi81 – 899Combined sources
Beta strandi93 – 11018Combined sources
Helixi114 – 1163Combined sources
Beta strandi121 – 13515Combined sources
Beta strandi140 – 1456Combined sources
Beta strandi152 – 16615Combined sources
Helixi176 – 19520Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A9VX-ray2.24A/B/C/D1-200[»]
ProteinModelPortaliQ9HJM3.
SMRiQ9HJM3. Positions 1-198.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HJM3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 193191Glutamine amidotransferase type-1UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiarCOG00087. Archaea.
COG0518. LUCA.
KOiK01951.
OMAiGGPDMDR.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_01510. GMP_synthase_A. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR004739. GMP_synth_N.
IPR023686. GMP_synthase_A.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HJM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIYVVDNG GQWTHREWRV LRELGVDTKI VPNDIDSSEL DGLDGLVLSG
60 70 80 90 100
GAPNIDEELD KLGSVGKYID DHNYPILGIC VGAQFIALHF GASVVKAKHP
110 120 130 140 150
EFGKTKVSVM HSENIFGGLP SEITVWENHN DEIINLPDDF TLAASSATCQ
160 170 180 190 200
VQGFYHKTRP IYATQFHPEV EHTQYGRDIF RNFIGICASY REIQKENFQH
Length:200
Mass (Da):22,471
Last modified:March 1, 2004 - v2
Checksum:i747E9F28574E7C6A
GO

Sequence cautioni

The sequence CAC12073 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445066 Genomic DNA. Translation: CAC12073.1. Different initiation.
RefSeqiWP_010901354.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC12073; CAC12073; CAC12073.
GeneIDi1457057.
KEGGitac:Ta0944m.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445066 Genomic DNA. Translation: CAC12073.1. Different initiation.
RefSeqiWP_010901354.1. NC_002578.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A9VX-ray2.24A/B/C/D1-200[»]
ProteinModelPortaliQ9HJM3.
SMRiQ9HJM3. Positions 1-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273075.Ta0944m.

Protein family/group databases

MEROPSiC26.A31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC12073; CAC12073; CAC12073.
GeneIDi1457057.
KEGGitac:Ta0944m.

Phylogenomic databases

eggNOGiarCOG00087. Archaea.
COG0518. LUCA.
KOiK01951.
OMAiGGPDMDR.

Enzyme and pathway databases

UniPathwayiUPA00189; UER00296.

Miscellaneous databases

EvolutionaryTraceiQ9HJM3.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_01510. GMP_synthase_A. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR004739. GMP_synth_N.
IPR023686. GMP_synthase_A.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUAAA_THEAC
AccessioniPrimary (citable) accession number: Q9HJM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: November 11, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.