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Q9HJM3 (GUAAA_THEAC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing] subunit A
EC=6.3.5.2
Alternative name(s):
Glutamine amidotransferase
Gene names
Name:guaAA
Ordered Locus Names:Ta0944
OrganismThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifier273075 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the synthesis of GMP from XMP By similarity. HAMAP MF_01510

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_01510

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_01510

Subunit structure

Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B) Potential.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain.

Sequence caution

The sequence CAC12073.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200GMP synthase [glutamine-hydrolyzing] subunit A HAMAP MF_01510
PRO_0000140235

Regions

Domain3 – 193191Glutamine amidotransferase type-1

Sites

Active site801Nucleophile By similarity
Active site1671 By similarity
Active site1691 By similarity

Secondary structure

1 ................................ 200
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9HJM3 [UniParc].

Last modified March 1, 2004. Version 2.
Checksum: 747E9F28574E7C6A

FASTA20022,471
        10         20         30         40         50         60 
MLKIYVVDNG GQWTHREWRV LRELGVDTKI VPNDIDSSEL DGLDGLVLSG GAPNIDEELD 

        70         80         90        100        110        120 
KLGSVGKYID DHNYPILGIC VGAQFIALHF GASVVKAKHP EFGKTKVSVM HSENIFGGLP 

       130        140        150        160        170        180 
SEITVWENHN DEIINLPDDF TLAASSATCQ VQGFYHKTRP IYATQFHPEV EHTQYGRDIF 

       190        200 
RNFIGICASY REIQKENFQH

« Hide

References

[1]"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
Nature 407:508-513(2000) [PubMed: 11029001] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL445066 Genomic DNA. Translation: CAC12073.1. Different initiation.
RefSeqNP_394403.1. NC_002578.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2A9VX-ray2.24A/B/C/D1-200[»]
ProteinModelPortalQ9HJM3.
SMRQ9HJM3. Positions 1-198.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1457057.
GenomeReviewsGene locus Ta0944 in contig AL139299_GR.
NMPDRfig|273075.1.peg.925.

Phylogenomic databases

HOGENOMHBG292341.
OMAGQYVHRI.
PhylomeDBQ9HJM3.
ProtClustDBPRK00758.

Enzyme and pathway databases

BioCycTACI273075:TA0944-MONOMER.

Family and domain databases

HAMAPMF_01510. GMP_synthase_A.
[Tree]
InterProIPR017926. GATASE_1.
IPR004739. GMP_synth_N.
IPR023686. GMP_synthase_A.
[Graphical view]
PfamPF00117. GATase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00888. GuaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAAA_THEAC
AccessionPrimary (citable) accession number: Q9HJM3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: January 25, 2012
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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