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Protein

Malate dehydrogenase

Gene

mdh

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADBy similarity1
Binding sitei88SubstrateBy similarity1
Binding sitei94SubstrateBy similarity1
Binding sitei101NADBy similarity1
Binding sitei126SubstrateBy similarity1
Binding sitei157SubstrateBy similarity1
Active sitei181Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADBy similarity6
Nucleotide bindingi124 – 126NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseBy similarity (EC:1.1.1.37By similarity)
Gene namesi
Name:mdh
Ordered Locus Names:Ta0952
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134951 – 325Malate dehydrogenaseAdd BLAST325

Proteomic databases

PRIDEiQ9HJL5.

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta0952.

Structurei

3D structure databases

ProteinModelPortaliQ9HJL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.Curated

Phylogenomic databases

eggNOGiarCOG00246. Archaea.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiMDLMQTA.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HJL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKKISVIG AGNVGATVAQ FLAAKQLGDV YLFDVVDGIP EGKALDIQEG
60 70 80 90 100
APHWRYDLDV VGFSTSDETK YKNMEGSDVI VVTAGLARKP GMSRDDLFDK
110 120 130 140 150
NVEIISDVSR NIKKYSPDSI IVVVSNPADI MAYALQKFTG IDPSKIMGLG
160 170 180 190 200
GSLDSSRFRT FLAKELNVSV EDVNAFVIGG HGDDMVPFIR YSSVAGIPIE
210 220 230 240 250
NLLSKEKIDE IVKRTRFGGG EIVNYLKTGS AFYAPGISIT AMVESVIMDK
260 270 280 290 300
KRVIPCAAYI TGKHADHYGI RDKFIGVPIK IGEKGVEQIY DIDFKPDELE
310 320
LWKKSVASVE ASSKKVDEWI AKHAH
Length:325
Mass (Da):35,524
Last modified:March 1, 2001 - v1
Checksum:iD6126D95B7EB1B31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199510 Genomic DNA. Translation: AAG28562.1.
AL445066 Genomic DNA. Translation: CAC12081.1.
RefSeqiWP_010901363.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC12081; CAC12081; CAC12081.
GeneIDi1456484.
KEGGitac:Ta0952.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199510 Genomic DNA. Translation: AAG28562.1.
AL445066 Genomic DNA. Translation: CAC12081.1.
RefSeqiWP_010901363.1. NC_002578.1.

3D structure databases

ProteinModelPortaliQ9HJL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273075.Ta0952.

Proteomic databases

PRIDEiQ9HJL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC12081; CAC12081; CAC12081.
GeneIDi1456484.
KEGGitac:Ta0952.

Phylogenomic databases

eggNOGiarCOG00246. Archaea.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiMDLMQTA.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMDH_THEAC
AccessioniPrimary (citable) accession number: Q9HJL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: October 5, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.