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Q9HJA6 (RIFK_THEAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Riboflavin kinase

Short name=RFK
EC=2.7.1.161
Alternative name(s):
CTP-dependent riboflavin kinase
CTP:riboflavin 5'-phosphotransferase
Flavokinase
Gene names
Name:ribK
Ordered Locus Names:Ta1064
OrganismThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) [Reference proteome] [HAMAP]
Taxonomic identifier273075 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) By similarity.

Catalytic activity

CTP + riboflavin = CDP + FMN.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.

Sequence similarities

Belongs to the archaeal riboflavin kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Riboflavin kinase
PRO_0000322106

Regions

Nucleotide binding102 – 1076CDP By similarity
Nucleotide binding200 – 2034CDP By similarity
Region1 – 9292H-T-H motif-like
Region93 – 220128Riboflavin kinase

Sites

Metal binding1311Magnesium By similarity
Metal binding1331Magnesium By similarity
Binding site1881FMN By similarity
Binding site1951FMN By similarity

Secondary structure

.................................. 220
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9HJA6 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: BB0F694447629612

FASTA22024,997
        10         20         30         40         50         60 
METDDQYYRA IKKIKEAAEA SNRAYLTSSK LADMLGISQQ SASRIIIDLE KNGYITRTVT 

        70         80         90        100        110        120 
KRGQILNITE KGLDVLYTEF ADLSRILAIK NNVVITGTVT SGMGEGRYYV ARKQYIIQFQ 

       130        140        150        160        170        180 
EKLGIIPYLG TLNIKVDQAS LPELRKIRGF RGIHIEGFKT EDRTFGSVKA FPAKIQNIPC 

       190        200        210        220 
FVIMPERTVY TDVIEIISDK YLREEINLHD GDRVSVEVYT 

« Hide

References

[1]"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL445066 Genomic DNA. Translation: CAC12192.1.
RefSeqNP_394524.1. NC_002578.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3CTAX-ray2.20A2-220[»]
ProteinModelPortalQ9HJA6.
SMRQ9HJA6. Positions 5-220.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273075.Ta1064.

Proteomic databases

PRIDEQ9HJA6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC12192; CAC12192; CAC12192.
GeneID1456578.
KEGGtac:Ta1064.

Phylogenomic databases

eggNOGCOG1339.
HOGENOMHOG000015512.
KOK07732.
OMAGAYYVRQ.

Enzyme and pathway databases

UniPathwayUPA00276; UER00929.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.40.30.30. 1 hit.
InterProIPR000835. HTH_MarR-typ.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023602. Riboflavin_kinase_CTP-dep.
IPR023465. Riboflavin_kinase_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF01982. CTP-dep_RFKase. 1 hit.
PF01047. MarR. 1 hit.
[Graphical view]
SUPFAMSSF82114. SSF82114. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ9HJA6.

Entry information

Entry nameRIFK_THEAC
AccessionPrimary (citable) accession number: Q9HJA6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways