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Q9HJA6

- RIFK_THEAC

UniProt

Q9HJA6 - RIFK_THEAC

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Protein
Riboflavin kinase
Gene
ribK, Ta1064
Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) By similarity.

Catalytic activityi

CTP + riboflavin = CDP + FMN.

Cofactori

Binds 1 magnesium ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi131 – 1311Magnesium By similarity
Metal bindingi133 – 1331Magnesium By similarity
Binding sitei188 – 1881FMN By similarity
Binding sitei195 – 1951FMN By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi102 – 1076CDP By similarity
Nucleotide bindingi200 – 2034CDP By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW
  3. riboflavin kinase activity Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. FMN biosynthetic process Source: UniProtKB-UniPathway
  2. riboflavin biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

Flavoprotein, FMN, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00276; UER00929.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin kinase (EC:2.7.1.161)
Short name:
RFK
Alternative name(s):
CTP-dependent riboflavin kinase
CTP:riboflavin 5'-phosphotransferase
Flavokinase
Gene namesi
Name:ribK
Ordered Locus Names:Ta1064
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001024: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Riboflavin kinase
PRO_0000322106Add
BLAST

Proteomic databases

PRIDEiQ9HJA6.

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta1064.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1712
Turni18 – 203
Beta strandi21 – 255
Helixi28 – 358
Helixi39 – 5113
Beta strandi54 – 607
Beta strandi63 – 686
Helixi70 – 8617
Beta strandi93 – 997
Helixi116 – 1227
Beta strandi133 – 1364
Helixi138 – 1403
Helixi141 – 1499
Beta strandi153 – 1553
Beta strandi168 – 1758
Beta strandi178 – 18710
Beta strandi192 – 1976
Beta strandi213 – 2186

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CTAX-ray2.20A2-220[»]
ProteinModelPortaliQ9HJA6.
SMRiQ9HJA6. Positions 5-220.

Miscellaneous databases

EvolutionaryTraceiQ9HJA6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9292H-T-H motif-like
Add
BLAST
Regioni93 – 220128Riboflavin kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1339.
HOGENOMiHOG000015512.
KOiK07732.
OMAiGAYYVRQ.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.40.30.30. 1 hit.
InterProiIPR000835. HTH_MarR-typ.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023602. Riboflavin_kinase_CTP-dep.
IPR023465. Riboflavin_kinase_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01982. CTP-dep_RFKase. 1 hit.
PF01047. MarR. 1 hit.
[Graphical view]
SUPFAMiSSF82114. SSF82114. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HJA6-1 [UniParc]FASTAAdd to Basket

« Hide

METDDQYYRA IKKIKEAAEA SNRAYLTSSK LADMLGISQQ SASRIIIDLE    50
KNGYITRTVT KRGQILNITE KGLDVLYTEF ADLSRILAIK NNVVITGTVT 100
SGMGEGRYYV ARKQYIIQFQ EKLGIIPYLG TLNIKVDQAS LPELRKIRGF 150
RGIHIEGFKT EDRTFGSVKA FPAKIQNIPC FVIMPERTVY TDVIEIISDK 200
YLREEINLHD GDRVSVEVYT 220
Length:220
Mass (Da):24,997
Last modified:March 1, 2001 - v1
Checksum:iBB0F694447629612
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445066 Genomic DNA. Translation: CAC12192.1.
RefSeqiNP_394524.1. NC_002578.1.
WP_010901475.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC12192; CAC12192; CAC12192.
GeneIDi1456578.
KEGGitac:Ta1064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445066 Genomic DNA. Translation: CAC12192.1 .
RefSeqi NP_394524.1. NC_002578.1.
WP_010901475.1. NC_002578.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3CTA X-ray 2.20 A 2-220 [» ]
ProteinModelPortali Q9HJA6.
SMRi Q9HJA6. Positions 5-220.
ModBasei Search...

Protein-protein interaction databases

STRINGi 273075.Ta1064.

Proteomic databases

PRIDEi Q9HJA6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC12192 ; CAC12192 ; CAC12192 .
GeneIDi 1456578.
KEGGi tac:Ta1064.

Phylogenomic databases

eggNOGi COG1339.
HOGENOMi HOG000015512.
KOi K07732.
OMAi GAYYVRQ.

Enzyme and pathway databases

UniPathwayi UPA00276 ; UER00929 .

Miscellaneous databases

EvolutionaryTracei Q9HJA6.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.40.30.30. 1 hit.
InterProi IPR000835. HTH_MarR-typ.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023602. Riboflavin_kinase_CTP-dep.
IPR023465. Riboflavin_kinase_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF01982. CTP-dep_RFKase. 1 hit.
PF01047. MarR. 1 hit.
[Graphical view ]
SUPFAMi SSF82114. SSF82114. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
    Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
    Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Entry informationi

Entry nameiRIFK_THEAC
AccessioniPrimary (citable) accession number: Q9HJA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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