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Q9HJA6

- RIFK_THEAC

UniProt

Q9HJA6 - RIFK_THEAC

Protein

Riboflavin kinase

Gene

ribK

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).By similarity

    Catalytic activityi

    CTP + riboflavin = CDP + FMN.

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi131 – 1311MagnesiumBy similarity
    Metal bindingi133 – 1331MagnesiumBy similarity
    Binding sitei188 – 1881FMNBy similarity
    Binding sitei195 – 1951FMNBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi102 – 1076CDPBy similarity
    Nucleotide bindingi200 – 2034CDPBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleotide binding Source: UniProtKB-KW
    3. riboflavin kinase activity Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. FMN biosynthetic process Source: UniProtKB-UniPathway
    2. riboflavin biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    Flavoprotein, FMN, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00276; UER00929.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Riboflavin kinase (EC:2.7.1.161)
    Short name:
    RFK
    Alternative name(s):
    CTP-dependent riboflavin kinase
    CTP:riboflavin 5'-phosphotransferase
    Flavokinase
    Gene namesi
    Name:ribK
    Ordered Locus Names:Ta1064
    OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
    Taxonomic identifieri273075 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
    ProteomesiUP000001024: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220Riboflavin kinasePRO_0000322106Add
    BLAST

    Proteomic databases

    PRIDEiQ9HJA6.

    Interactioni

    Protein-protein interaction databases

    STRINGi273075.Ta1064.

    Structurei

    Secondary structure

    1
    220
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 1712
    Turni18 – 203
    Beta strandi21 – 255
    Helixi28 – 358
    Helixi39 – 5113
    Beta strandi54 – 607
    Beta strandi63 – 686
    Helixi70 – 8617
    Beta strandi93 – 997
    Helixi116 – 1227
    Beta strandi133 – 1364
    Helixi138 – 1403
    Helixi141 – 1499
    Beta strandi153 – 1553
    Beta strandi168 – 1758
    Beta strandi178 – 18710
    Beta strandi192 – 1976
    Beta strandi213 – 2186

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3CTAX-ray2.20A2-220[»]
    ProteinModelPortaliQ9HJA6.
    SMRiQ9HJA6. Positions 5-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9HJA6.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9292H-T-H motif-likeAdd
    BLAST
    Regioni93 – 220128Riboflavin kinaseAdd
    BLAST

    Sequence similaritiesi

    Belongs to the archaeal riboflavin kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG1339.
    HOGENOMiHOG000015512.
    KOiK07732.
    OMAiGAYYVRQ.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.40.30.30. 1 hit.
    InterProiIPR000835. HTH_MarR-typ.
    IPR015865. Riboflavin_kinase_bac/euk.
    IPR023602. Riboflavin_kinase_CTP-dep.
    IPR023465. Riboflavin_kinase_domain.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF01982. CTP-dep_RFKase. 1 hit.
    PF01047. MarR. 1 hit.
    [Graphical view]
    SUPFAMiSSF82114. SSF82114. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9HJA6-1 [UniParc]FASTAAdd to Basket

    « Hide

    METDDQYYRA IKKIKEAAEA SNRAYLTSSK LADMLGISQQ SASRIIIDLE    50
    KNGYITRTVT KRGQILNITE KGLDVLYTEF ADLSRILAIK NNVVITGTVT 100
    SGMGEGRYYV ARKQYIIQFQ EKLGIIPYLG TLNIKVDQAS LPELRKIRGF 150
    RGIHIEGFKT EDRTFGSVKA FPAKIQNIPC FVIMPERTVY TDVIEIISDK 200
    YLREEINLHD GDRVSVEVYT 220
    Length:220
    Mass (Da):24,997
    Last modified:March 1, 2001 - v1
    Checksum:iBB0F694447629612
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445066 Genomic DNA. Translation: CAC12192.1.
    RefSeqiNP_394524.1. NC_002578.1.
    WP_010901475.1. NC_002578.1.

    Genome annotation databases

    EnsemblBacteriaiCAC12192; CAC12192; CAC12192.
    GeneIDi1456578.
    KEGGitac:Ta1064.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445066 Genomic DNA. Translation: CAC12192.1 .
    RefSeqi NP_394524.1. NC_002578.1.
    WP_010901475.1. NC_002578.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3CTA X-ray 2.20 A 2-220 [» ]
    ProteinModelPortali Q9HJA6.
    SMRi Q9HJA6. Positions 5-220.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273075.Ta1064.

    Proteomic databases

    PRIDEi Q9HJA6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC12192 ; CAC12192 ; CAC12192 .
    GeneIDi 1456578.
    KEGGi tac:Ta1064.

    Phylogenomic databases

    eggNOGi COG1339.
    HOGENOMi HOG000015512.
    KOi K07732.
    OMAi GAYYVRQ.

    Enzyme and pathway databases

    UniPathwayi UPA00276 ; UER00929 .

    Miscellaneous databases

    EvolutionaryTracei Q9HJA6.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.40.30.30. 1 hit.
    InterProi IPR000835. HTH_MarR-typ.
    IPR015865. Riboflavin_kinase_bac/euk.
    IPR023602. Riboflavin_kinase_CTP-dep.
    IPR023465. Riboflavin_kinase_domain.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF01982. CTP-dep_RFKase. 1 hit.
    PF01047. MarR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82114. SSF82114. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
      Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
      Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

    Entry informationi

    Entry nameiRIFK_THEAC
    AccessioniPrimary (citable) accession number: Q9HJA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3