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Reviewed, UniProtKB/Swiss-Prot Q9HJA6 (RIFK_THEAC)

Last modified November 3, 2009. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Riboflavin kinase
      Short name=RFK
    EC=2.7.1.161
Alternative name(s):
    CTP:riboflavin 5'-phosphotransferase
    CTP-dependent riboflavin kinase
    Flavokinase
Gene names
Name: rfk
Ordered Locus Names: Ta1064
OrganismThermoplasma acidophilum [Complete proteome] [HAMAP]
Taxonomic identifier2303 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) By similarity.

Catalytic activity

CTP + riboflavin = CDP + FMN. HAMAP MF_01285

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1. HAMAP MF_01285

Sequence similarities

Belongs to the archaeal riboflavin kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Riboflavin kinase HAMAP MF_01285
PRO_0000322106

Regions

Nucleotide binding102 – 1076CDP By similarity
Nucleotide binding200 – 2034CDP By similarity
Region1 – 9292H-T-H motif-like HAMAP MF_01285
Region93 – 220128Riboflavin kinase HAMAP MF_01285

Sites

Metal binding1311Magnesium By similarity
Metal binding1331Magnesium By similarity
Binding site1881FMN By similarity
Binding site1951FMN By similarity

Secondary structure

.................................. 220
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9HJA6-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: BB0F694447629612

FASTA22024,997
        10         20         30         40         50         60 
METDDQYYRA IKKIKEAAEA SNRAYLTSSK LADMLGISQQ SASRIIIDLE KNGYITRTVT 

        70         80         90        100        110        120 
KRGQILNITE KGLDVLYTEF ADLSRILAIK NNVVITGTVT SGMGEGRYYV ARKQYIIQFQ 

       130        140        150        160        170        180 
EKLGIIPYLG TLNIKVDQAS LPELRKIRGF RGIHIEGFKT EDRTFGSVKA FPAKIQNIPC 

       190        200        210        220 
FVIMPERTVY TDVIEIISDK YLREEINLHD GDRVSVEVYT 

« Hide

References

[1]"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
Nature 407:508-513(2000) [PubMed: 11029001] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25905 / AMRC-C165 / DSM 1728 / IFO 15155 / JCM 9062.

Cross-references

Sequence databases

AL445066 Genomic DNA. Translation: CAC12192.1.
RefSeqNP_394524.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
3CTAX-ray2.20A2-220[»]
ModBaseSearch...

Genome annotation databases

GeneID1456578.
GenomeReviewsGene locus Ta1064 in contig AL139299_GR.
KEGGtac:Ta1064.
NMPDRfig|273075.1.peg.1046.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9HJA6.
OMAGAYYVRQ.

Enzyme and pathway databases

BioCycTACI273075:TA1064-MON.

Family and domain databases

HAMAPMF_01285. Fused.
[Tree]
InterProIPR000835. HTH_MarR.
IPR002834. Riboflavin_kinase_arc.
[Graphical view]
PfamPF01982. CTP-dep_RFKase. 1 hit.
PF01047. MarR. 1 hit.
[Graphical view]
ProDomPD015839. DUF120. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameRIFK_THEAC
AccessionPrimary (citable) accession number: Q9HJA6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2001
Last modified: November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents