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Q9HJ95

- PGK_THEAC

UniProt

Q9HJ95 - PGK_THEAC

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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391SubstrateBy similarity
Binding sitei117 – 1171SubstrateBy similarity
Binding sitei157 – 1571SubstrateBy similarity
Binding sitei332 – 3321ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi358 – 3614ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:Ta1075
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001024: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Phosphoglycerate kinasePRO_0000146073Add
BLAST

Proteomic databases

PRIDEiQ9HJ95.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi273075.Ta1075.

Structurei

3D structure databases

ProteinModelPortaliQ9HJ95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 243Substrate bindingBy similarity
Regioni60 – 634Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227108.
KOiK00927.
OMAiAGHPVGK.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HJ95-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MDEFFLMNSF DLAGKTVYLR VDINAPVNPL TGEIMGIDRF RAHIDTIRNL
60 70 80 90 100
RNSKVVIVAH QSRPGKDDFI SLRQHAQILS HLLNKRVQFV DQLFGSQVNR
110 120 130 140 150
AVSEMSDGDI VMLENSRFYS EEVDLTTIES MESSNIVRSL SPLFDYFIID
160 170 180 190 200
AFAAIHRAQT TLVGFHRIKP NIAGTLIERE VSMIERFRKI REKPKIAILG
210 220 230 240 250
GAKIEDSIAV SENFLSRGFV DKILTGGVVA NAFLWASGFD IGKKNREFIM
260 270 280 290 300
KNNGDYEKLL DKCRAILSKY GDKLVMPTDF VMNPSGQRIS INEKIPDDQI
310 320 330 340 350
LADIGLDTIV EYSEIIDGAR AIFMNGPMGM YEIEDYSSGT REVFTAVAHS
360 370 380 390 400
KAFKLAGGGH TLSALDKLGL TKMIDHASTG GGALISYLSG ETMPVLEALK

ESKKLFEG
Length:408
Mass (Da):45,372
Last modified:March 1, 2001 - v1
Checksum:i6F3C6C2357FD5849
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445066 Genomic DNA. Translation: CAC12203.1.
RefSeqiNP_394535.1. NC_002578.1.
WP_010901486.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC12203; CAC12203; CAC12203.
GeneIDi1456589.
KEGGitac:Ta1075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445066 Genomic DNA. Translation: CAC12203.1 .
RefSeqi NP_394535.1. NC_002578.1.
WP_010901486.1. NC_002578.1.

3D structure databases

ProteinModelPortali Q9HJ95.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273075.Ta1075.

Proteomic databases

PRIDEi Q9HJ95.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC12203 ; CAC12203 ; CAC12203 .
GeneIDi 1456589.
KEGGi tac:Ta1075.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227108.
KOi K00927.
OMAi AGHPVGK.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
    Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
    Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Entry informationi

Entry nameiPGK_THEAC
AccessioniPrimary (citable) accession number: Q9HJ95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3