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Protein

GTP cyclohydrolase MptA

Gene

mptA

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion per subunit.UniRule annotation

Pathwayi: 5,6,7,8-tetrahydromethanopterin biosynthesis

This protein is involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei144May be catalytically importantUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00065.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase MptAUniRule annotation (EC:3.5.4.39UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IVUniRule annotation
Gene namesi
Name:mptAUniRule annotation
Ordered Locus Names:Ta1138
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001477531 – 286GTP cyclohydrolase MptAAdd BLAST286

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi273075.Ta1138.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04301. Archaea.
COG1469. LUCA.
HOGENOMiHOG000280680.
KOiK17488.
OMAiPCSQGMS.

Family and domain databases

HAMAPiMF_01527_A. GTP_cyclohydrol_A. 1 hit.
InterProiIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HJ35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDFLDVQKE TPRIRIAIDR VGVKNIKFPL KIHDDFAFLT LNLFVDVPAD
60 70 80 90 100
RKGADMSRAV ESIQKVINAG SYGERIGDIG IAICDEALSR FNYSEKAQCE
110 120 130 140 150
VNIQYYRRSG ERYLEYRMYV ETAKDRKQIM KNEIGISYVT MTACPCAMET
160 170 180 190 200
TRALISMDNP DISDAISAIP TITHNQRNVT KLTVDNRSKM ITVWDLADVM
210 220 230 240 250
ERVQGKPLDS LLKRVEEGRL VYSAHRNPKF VEDVVREIAY EAARVLGVPD
260 270 280
EATIKVSSES DESIHPHNAY AEIDTTAGEL RKLHLH
Length:286
Mass (Da):32,454
Last modified:March 1, 2001 - v1
Checksum:i19366865C1577316
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445066 Genomic DNA. Translation: CAC12264.1.
RefSeqiWP_010901546.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC12264; CAC12264; CAC12264.
GeneIDi1456642.
KEGGitac:Ta1138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445066 Genomic DNA. Translation: CAC12264.1.
RefSeqiWP_010901546.1. NC_002578.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273075.Ta1138.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC12264; CAC12264; CAC12264.
GeneIDi1456642.
KEGGitac:Ta1138.

Phylogenomic databases

eggNOGiarCOG04301. Archaea.
COG1469. LUCA.
HOGENOMiHOG000280680.
KOiK17488.
OMAiPCSQGMS.

Enzyme and pathway databases

UniPathwayiUPA00065.

Family and domain databases

HAMAPiMF_01527_A. GTP_cyclohydrol_A. 1 hit.
InterProiIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMPTA_THEAC
AccessioniPrimary (citable) accession number: Q9HJ35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2001
Last modified: November 11, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.