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Protein

GTP cyclohydrolase MptA

Gene

mptA

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion per subunit.UniRule annotation

Pathwayi: 5,6,7,8-tetrahydromethanopterin biosynthesis

This protein is involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei144May be catalytically importantUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciTACI273075:G1GT7-1251-MONOMER
UniPathwayiUPA00065

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase MptAUniRule annotation (EC:3.5.4.39UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IVUniRule annotation
Gene namesi
Name:mptAUniRule annotation
Ordered Locus Names:Ta1138
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001477531 – 286GTP cyclohydrolase MptAAdd BLAST286

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi273075.Ta1138

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04301 Archaea
COG1469 LUCA
HOGENOMiHOG000280680
KOiK17488
OMAiHNQRGRG
OrthoDBiPOG093Z06SZ

Family and domain databases

HAMAPiMF_01527_A GTP_cyclohydrol_A, 1 hit
InterProiView protein in InterPro
IPR003801 GTP_cyclohydrolase_FolE2/MptA
IPR022840 GTP_cyclohydrolase_MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit
TIGRFAMsiTIGR00294 TIGR00294, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HJ35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDFLDVQKE TPRIRIAIDR VGVKNIKFPL KIHDDFAFLT LNLFVDVPAD
60 70 80 90 100
RKGADMSRAV ESIQKVINAG SYGERIGDIG IAICDEALSR FNYSEKAQCE
110 120 130 140 150
VNIQYYRRSG ERYLEYRMYV ETAKDRKQIM KNEIGISYVT MTACPCAMET
160 170 180 190 200
TRALISMDNP DISDAISAIP TITHNQRNVT KLTVDNRSKM ITVWDLADVM
210 220 230 240 250
ERVQGKPLDS LLKRVEEGRL VYSAHRNPKF VEDVVREIAY EAARVLGVPD
260 270 280
EATIKVSSES DESIHPHNAY AEIDTTAGEL RKLHLH
Length:286
Mass (Da):32,454
Last modified:March 1, 2001 - v1
Checksum:i19366865C1577316
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445066 Genomic DNA Translation: CAC12264.1
RefSeqiWP_010901546.1, NC_002578.1

Genome annotation databases

EnsemblBacteriaiCAC12264; CAC12264; CAC12264
GeneIDi1456642
KEGGitac:Ta1138

Similar proteinsi

Entry informationi

Entry nameiMPTA_THEAC
AccessioniPrimary (citable) accession number: Q9HJ35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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