Q9HJ34 (RIBL_THEAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FAD synthase
EC=2.7.7.2

Alternative name(s):
FMN adenylyltransferase
Flavin adenine dinucleotide synthase

Gene names

Name:	ribL
Ordered Locus Names:	Ta1139

Organism

Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) [Reference proteome] [HAMAP]

Taxonomic identifier

273075 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma › Thermoplasma acidophilum

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme By similarity. HAMAP-Rule MF_02115
Catalytic activity	ATP + FMN = diphosphate + FAD. HAMAP-Rule MF_02115
Cofactor	Divalent metal cations By similarity.
Pathway	Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1. HAMAP-Rule MF_02115
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the archaeal FAD synthase family.

Ontologies

Keywords
Ligand	ATP-binding FAD FMN Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	FAD biosynthetic process Inferred from electronic annotation. Source: HAMAP FMN metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP FMN adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	FAD synthase HAMAP-Rule MF_02115		PRO_0000406286
Regions
	Nucleotide binding	9 – 10	2	ATP By similarity
	Nucleotide binding	14 – 17	4	ATP By similarity
	Nucleotide binding	91 – 94	4	ATP By similarity
Sites
	Binding site	120	1	ATP; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9HJ34 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: C047A9F91F4F595B	FASTA	142	16,196
	10 20 30 40 50 60 MVRVMATGVF DIIHLGHIHY LRESKKLGDE LVVVVARDST ARKNGKVPIF DENSRLKLVS 70 80 90 100 110 120 ELKPVDRAIL GHEDDMMKTV VEVMPDIITL GYDQKFDEAD LKRKLDQIGV NSRIVRISKY 130 140 DGNLNSSSMV RKKIMELIGE RF

References

[1]

"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445066 Genomic DNA. Translation: CAC12265.1.
RefSeq	NP_394596.1. NC_002578.1.
3D structure databases
ProteinModelPortal	Q9HJ34.
ModBase	Search...
Protein-protein interaction databases
STRING	273075.Ta1139.
Proteomic databases
PRIDE	Q9HJ34.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAC12265; CAC12265; CAC12265.
GeneID	1456643.
KEGG	tac:Ta1139.
Phylogenomic databases
eggNOG	COG0615.
HOGENOM	HOG000284153.
KO	K14656.
OMA	VAHDETV.
ProtClustDB	CLSK227867.
Enzyme and pathway databases
UniPathway	UPA00277; UER00407.
Family and domain databases
Gene3D	3.40.50.620. 1 hit.
HAMAP	MF_02115. FAD_synth_arch.
InterPro	IPR004821. Cyt_trans-like. IPR024902. FAD_synth_RibL. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00125. cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RIBL_THEAC

Accession

Primary (citable) accession number: Q9HJ34

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 5, 2011
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program