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Protein

DNA ligase

Gene

lig

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei248ATPUniRule annotation1
Active sitei250N6-AMP-lysine intermediateUniRule annotation1
Binding sitei255ATPUniRule annotation1
Binding sitei270ATPUniRule annotation1
Binding sitei300ATPUniRule annotation1
Binding sitei341ATPUniRule annotation1
Binding sitei418ATPUniRule annotation1
Binding sitei424ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTACI273075:G1GT7-1261-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Ta1148
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000596201 – 588DNA ligaseAdd BLAST588

Proteomic databases

PRIDEiQ9HJ26

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta1148

Structurei

3D structure databases

ProteinModelPortaliQ9HJ26
SMRiQ9HJ26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HJ26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFSVVADAF EKMESTTKRL ELTDLLVNLL KEADDDLPLL IYLLEGKLGP
60 70 80 90 100
DYLGIETQMS DKLIIKALSV ASNISEDEIA KEYAKAGDIG TIAKEIAEKR
110 120 130 140 150
SLRSLVQEEM TVKYIHDTLM KMARTTGSGS TKARVDAYMD LFLNSTPKEI
160 170 180 190 200
MYITRIITGK LRIGISDATI LDAIVKAFAD EKYSEDIENA FNFHPDLGYI
210 220 230 240 250
ASELRKGNID AILKLGPTPM IPFKVMLAER LRSVEEILEK MGGRCAFEYK
260 270 280 290 300
YDGMRTETHI ERGKVRLFSR GNEETTNQFP DITKAASETF KVDSAILDGE
310 320 330 340 350
AVPYDPDTGE LYPFQVISHR RGRKYDLDKV SSEIPITVFL FDIVYLNGRD
360 370 380 390 400
LSKTPYTERR KILESIFTES DSFRLAKRIE SGDPAEVHRF FNSAIEDGCE
410 420 430 440 450
GLVAKSTSPD SFYKAGARGW LWIKLKRDYQ AQLWDTLDLT VVGAFYGHGR
460 470 480 490 500
RKGTYGALLL ATYNDKNDTF ETVCKLGSGF SDDVLFSLPK KFEQYVSKEK
510 520 530 540 550
PARVISNLEP DVWFYPAVVM EVIGAEITVS PIHTCAYGEI EKDSGLSVRF
560 570 580
PRFTGKWRED KKPEDSTTSR EILEMYKEQK KTITEEKS
Length:588
Mass (Da):66,538
Last modified:March 1, 2001 - v1
Checksum:iFFD61667871BE291
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445066 Genomic DNA Translation: CAC12273.1
RefSeqiWP_010901556.1, NC_002578.1

Genome annotation databases

EnsemblBacteriaiCAC12273; CAC12273; CAC12273
GeneIDi1456651
KEGGitac:Ta1148

Similar proteinsi

Entry informationi

Entry nameiDNLI_THEAC
AccessioniPrimary (citable) accession number: Q9HJ26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health