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Q9HIW5 (SYW_THEAC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:Ta1211
OrganismThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) [Reference proteome] [HAMAP]
Taxonomic identifier273075 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 426426Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136735

Regions

Motif66 – 749"HIGH" region HAMAP-Rule MF_00140
Motif314 – 3185"KMSKS" region HAMAP-Rule MF_00140

Sequences

Sequence LengthMass (Da)Tools
Q9HIW5 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: CC019B7FC2B5609E

FASTA42649,200
        10         20         30         40         50         60 
MINPWSSSDF FDYERLKREF GIGDMNVPFD HFLFRRHLIL GQRSIDYIDY ALKHHMKFNV 

        70         80         90        100        110        120 
MTGLMPSGEM HLGNKSAIDQ VIFFQKLGGR VSIAVADLES YSTRGISLER AREVAIEKYI 

       130        140        150        160        170        180 
LNYIAMGLEP CEIYFQSRNS DVQFLAYMLG NRTNMSELRS LYGFTDTHDL LHINAPLIQA 

       190        200        210        220        230        240 
ADVLHTQMKK YGGPAPTVVP VGFDQDPHLR LMRDLAKRMR IFNIQLENDL VVSVRGKDDP 

       250        260        270        280        290        300 
KEYIDMAYEY LSSRYTNVKK DYEYRVVRAD GVDQQDLVGI DLDLAHMETK YNDFAFIAPS 

       310        320        330        340        350        360 
ATYQKLMKGL KGGKMSSSVP DSLISLNDDP KEARRKIMAG MTGGRDTEEE QRRLGGEPDR 

       370        380        390        400        410        420 
CPIFDLYNYE IDDDKHVKEV YDDCRNGKRM CGFCKREIAD RMASWLSDLS KKREEAREKL 


SLYIHE 

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References

[1]"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL445066 Genomic DNA. Translation: CAC12336.1.
RefSeqNP_394667.1. NC_002578.1.

3D structure databases

ProteinModelPortalQ9HIW5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273075.Ta1211.

Proteomic databases

PRIDEQ9HIW5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC12336; CAC12336; CAC12336.
GeneID1456706.
KEGGtac:Ta1211.

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000224743.
KOK01867.
OMASIYHRFM.
ProtClustDBPRK12285.

Family and domain databases

Gene3D3.40.50.620. 2 hits.
HAMAPMF_00140_A. Trp_tRNA_synth_A.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 2 hits.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
ProtoNetSearch...

Entry information

Entry nameSYW_THEAC
AccessionPrimary (citable) accession number: Q9HIW5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2001
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries