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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTACI273075:G1GT7-1329-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:Ta1211
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367351 – 426Tryptophan--tRNA ligaseAdd BLAST426

Proteomic databases

PRIDEiQ9HIW5

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta1211

Structurei

3D structure databases

ProteinModelPortaliQ9HIW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi66 – 74"HIGH" region9
Motifi314 – 318"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
HOGENOMiHOG000224743
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z044X

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 2 hits
PRINTSiPR01039 TRNASYNTHTRP

Sequencei

Sequence statusi: Complete.

Q9HIW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINPWSSSDF FDYERLKREF GIGDMNVPFD HFLFRRHLIL GQRSIDYIDY
60 70 80 90 100
ALKHHMKFNV MTGLMPSGEM HLGNKSAIDQ VIFFQKLGGR VSIAVADLES
110 120 130 140 150
YSTRGISLER AREVAIEKYI LNYIAMGLEP CEIYFQSRNS DVQFLAYMLG
160 170 180 190 200
NRTNMSELRS LYGFTDTHDL LHINAPLIQA ADVLHTQMKK YGGPAPTVVP
210 220 230 240 250
VGFDQDPHLR LMRDLAKRMR IFNIQLENDL VVSVRGKDDP KEYIDMAYEY
260 270 280 290 300
LSSRYTNVKK DYEYRVVRAD GVDQQDLVGI DLDLAHMETK YNDFAFIAPS
310 320 330 340 350
ATYQKLMKGL KGGKMSSSVP DSLISLNDDP KEARRKIMAG MTGGRDTEEE
360 370 380 390 400
QRRLGGEPDR CPIFDLYNYE IDDDKHVKEV YDDCRNGKRM CGFCKREIAD
410 420
RMASWLSDLS KKREEAREKL SLYIHE
Length:426
Mass (Da):49,200
Last modified:March 1, 2001 - v1
Checksum:iCC019B7FC2B5609E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445066 Genomic DNA Translation: CAC12336.1
RefSeqiWP_010901618.1, NC_002578.1

Genome annotation databases

EnsemblBacteriaiCAC12336; CAC12336; CAC12336
GeneIDi1456706
KEGGitac:Ta1211

Similar proteinsi

Entry informationi

Entry nameiSYW_THEAC
AccessioniPrimary (citable) accession number: Q9HIW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health