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Q9HIW5

- SYW_THEAC

UniProt

Q9HIW5 - SYW_THEAC

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Short name:
    TrpRSUniRule annotation
    Gene namesi
    Name:trpSUniRule annotation
    Ordered Locus Names:Ta1211
    OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
    Taxonomic identifieri273075 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
    ProteomesiUP000001024: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 426426Tryptophan--tRNA ligasePRO_0000136735Add
    BLAST

    Proteomic databases

    PRIDEiQ9HIW5.

    Interactioni

    Protein-protein interaction databases

    STRINGi273075.Ta1211.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HIW5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi66 – 749"HIGH" region
    Motifi314 – 3185"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    HOGENOMiHOG000224743.
    KOiK01867.
    OMAiSIYHRFM.

    Family and domain databases

    Gene3Di3.40.50.620. 2 hits.
    HAMAPiMF_00140_A. Trp_tRNA_synth_A.
    InterProiIPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 2 hits.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.

    Sequencei

    Sequence statusi: Complete.

    Q9HIW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MINPWSSSDF FDYERLKREF GIGDMNVPFD HFLFRRHLIL GQRSIDYIDY    50
    ALKHHMKFNV MTGLMPSGEM HLGNKSAIDQ VIFFQKLGGR VSIAVADLES 100
    YSTRGISLER AREVAIEKYI LNYIAMGLEP CEIYFQSRNS DVQFLAYMLG 150
    NRTNMSELRS LYGFTDTHDL LHINAPLIQA ADVLHTQMKK YGGPAPTVVP 200
    VGFDQDPHLR LMRDLAKRMR IFNIQLENDL VVSVRGKDDP KEYIDMAYEY 250
    LSSRYTNVKK DYEYRVVRAD GVDQQDLVGI DLDLAHMETK YNDFAFIAPS 300
    ATYQKLMKGL KGGKMSSSVP DSLISLNDDP KEARRKIMAG MTGGRDTEEE 350
    QRRLGGEPDR CPIFDLYNYE IDDDKHVKEV YDDCRNGKRM CGFCKREIAD 400
    RMASWLSDLS KKREEAREKL SLYIHE 426
    Length:426
    Mass (Da):49,200
    Last modified:March 1, 2001 - v1
    Checksum:iCC019B7FC2B5609E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445066 Genomic DNA. Translation: CAC12336.1.
    RefSeqiNP_394667.1. NC_002578.1.
    WP_010901618.1. NC_002578.1.

    Genome annotation databases

    EnsemblBacteriaiCAC12336; CAC12336; CAC12336.
    GeneIDi1456706.
    KEGGitac:Ta1211.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445066 Genomic DNA. Translation: CAC12336.1 .
    RefSeqi NP_394667.1. NC_002578.1.
    WP_010901618.1. NC_002578.1.

    3D structure databases

    ProteinModelPortali Q9HIW5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273075.Ta1211.

    Proteomic databases

    PRIDEi Q9HIW5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC12336 ; CAC12336 ; CAC12336 .
    GeneIDi 1456706.
    KEGGi tac:Ta1211.

    Phylogenomic databases

    eggNOGi COG0180.
    HOGENOMi HOG000224743.
    KOi K01867.
    OMAi SIYHRFM.

    Family and domain databases

    Gene3Di 3.40.50.620. 2 hits.
    HAMAPi MF_00140_A. Trp_tRNA_synth_A.
    InterProi IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 2 hits.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
      Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
      Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

    Entry informationi

    Entry nameiSYW_THEAC
    AccessioniPrimary (citable) accession number: Q9HIW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3