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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:Ta1211
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001024 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Tryptophan--tRNA ligasePRO_0000136735Add
BLAST

Proteomic databases

PRIDEiQ9HIW5.

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta1211.

Structurei

3D structure databases

ProteinModelPortaliQ9HIW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi66 – 749"HIGH" region
Motifi314 – 3185"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000224743.
KOiK01867.
OMAiSIYHRFM.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 2 hits.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.

Sequencei

Sequence statusi: Complete.

Q9HIW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINPWSSSDF FDYERLKREF GIGDMNVPFD HFLFRRHLIL GQRSIDYIDY
60 70 80 90 100
ALKHHMKFNV MTGLMPSGEM HLGNKSAIDQ VIFFQKLGGR VSIAVADLES
110 120 130 140 150
YSTRGISLER AREVAIEKYI LNYIAMGLEP CEIYFQSRNS DVQFLAYMLG
160 170 180 190 200
NRTNMSELRS LYGFTDTHDL LHINAPLIQA ADVLHTQMKK YGGPAPTVVP
210 220 230 240 250
VGFDQDPHLR LMRDLAKRMR IFNIQLENDL VVSVRGKDDP KEYIDMAYEY
260 270 280 290 300
LSSRYTNVKK DYEYRVVRAD GVDQQDLVGI DLDLAHMETK YNDFAFIAPS
310 320 330 340 350
ATYQKLMKGL KGGKMSSSVP DSLISLNDDP KEARRKIMAG MTGGRDTEEE
360 370 380 390 400
QRRLGGEPDR CPIFDLYNYE IDDDKHVKEV YDDCRNGKRM CGFCKREIAD
410 420
RMASWLSDLS KKREEAREKL SLYIHE
Length:426
Mass (Da):49,200
Last modified:March 1, 2001 - v1
Checksum:iCC019B7FC2B5609E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445066 Genomic DNA. Translation: CAC12336.1.
RefSeqiNP_394667.1. NC_002578.1.
WP_010901618.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC12336; CAC12336; CAC12336.
GeneIDi1456706.
KEGGitac:Ta1211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445066 Genomic DNA. Translation: CAC12336.1.
RefSeqiNP_394667.1. NC_002578.1.
WP_010901618.1. NC_002578.1.

3D structure databases

ProteinModelPortaliQ9HIW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273075.Ta1211.

Proteomic databases

PRIDEiQ9HIW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC12336; CAC12336; CAC12336.
GeneIDi1456706.
KEGGitac:Ta1211.

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000224743.
KOiK01867.
OMAiSIYHRFM.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 2 hits.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
    Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
    Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Entry informationi

Entry nameiSYW_THEAC
AccessioniPrimary (citable) accession number: Q9HIW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2001
Last modified: May 27, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.