ID   Q9HIW2_THEAC            Unreviewed;       186 AA.
AC   Q9HIW2;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   RecName: Full=thymidine kinase {ECO:0000256|ARBA:ARBA00012118};
DE            EC=2.7.1.21 {ECO:0000256|ARBA:ARBA00012118};
GN   OrderedLocusNames=Ta1214 {ECO:0000313|EMBL:CAC12339.1};
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075 {ECO:0000313|EMBL:CAC12339.1, ECO:0000313|Proteomes:UP000001024};
RN   [1] {ECO:0000313|EMBL:CAC12339.1, ECO:0000313|Proteomes:UP000001024}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165
RC   {ECO:0000313|Proteomes:UP000001024};
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.L., Koretke K.K., Volker C.,
RA   Mewes H.W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000256|ARBA:ARBA00007587}.
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DR   EMBL; AL445066; CAC12339.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9HIW2; -.
DR   STRING; 273075.gene:9572438; -.
DR   PaxDb; 273075-Ta1214; -.
DR   EnsemblBacteria; CAC12339; CAC12339; CAC12339.
DR   KEGG; tac:Ta1214; -.
DR   eggNOG; arCOG04798; Archaea.
DR   HOGENOM; CLU_064400_3_0_2; -.
DR   InParanoid; Q9HIW2; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.60.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   InterPro; IPR020633; Thymidine_kinase_CS.
DR   PANTHER; PTHR11441; THYMIDINE KINASE; 1.
DR   PANTHER; PTHR11441:SF0; THYMIDINE KINASE, CYTOSOLIC; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CAC12339.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001024};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   ACT_SITE        76
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR035805-1"
SQ   SEQUENCE   186 AA;  20994 MW;  2B49C2AFA7BEB5F4 CRC64;
     MFSGKTSRLI ELMERHILAG RKVTLFKPEI DSRYSENEVV THKGIKLPAV IAPTDERFGE
     FLAARTRDSN VLGFDEAQFW KPSSRLPQHL EDLANSGRTV YVAALNRDHF GNPFRMTVDI
     LAISDEIYTL SAVCSRCGSD AIFTQRIING SPAFGEIIRI GGKDLYEPRC RNCFVWPSAQ
     KRITDL
//