Reviewed, UniProtKB/Swiss-Prot Q9HIK9 (OTCC_THEAC)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase, catabolic
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	Ta1330

Organism

Thermoplasma acidophilum [Complete proteome] [HAMAP]

Taxonomic identifier

2303 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000113079
Regions
	Region	50 – 54	5	Carbamoyl phosphate binding By similarity
	Region	262 – 265	4	Ornithine binding By similarity
Sites
	Binding site	101	1	Carbamoyl phosphate By similarity
	Binding site	128	1	Carbamoyl phosphate By similarity
	Site	27	1	Important for structural integrity By similarity
	Site	141	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9HIK9-1 [UniParc]. Last modified July 11, 2003. Version 2. Checksum: C8987FBE82159DE8	FASTA	305	34,299
	10 20 30 40 50 60 MSKRDILSVL DMEKDLSEII DLSIELKKNR YRSYESLRNK VLGLIFEKPS TRTRTSLEVA 70 80 90 100 110 120 IDQLGGHAVY LNPSEMQLGR GETISDTGHV LSRFLDAIAY RAYDHRNVVE LARSTSIPVI 130 140 150 160 170 180 NALDDVEHPL QIVADFMTIK EKKGRFTNLK FSYIGDGNNM ANSLMLGAAI LGTDMYVASP 190 200 210 220 230 240 KGFEPKQEFV EKARSIAKQH GSSITITNDP VEAARDADVI YTDVWISMGE ESKKGEKEKA 250 260 270 280 290 300 FKDFQINEKL VSNAKRDYIF MHCLPAHRGL EVTDGVADSI NSVIFDEAEN RLHSEKGVLY KLLSY

References

[1]

"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / AMRC-C165 / DSM 1728 / IFO 15155 / JCM 9062.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445067 Genomic DNA. Translation: CAC12451.1. Different initiation.
RefSeq	NP_394786.2.
3D structure databases
SMR	Q9HIK9. Positions 2-303.
ModBase	Search...
Genome annotation databases
GeneID	1456805.
KEGG	tac:Ta1330.
NMPDR	fig|273075.1.peg.1308.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG579429.
OMA	ENRMHTA.
Enzyme and pathway databases
BioCyc	TACI273075:TA1330-MONOMER.
BRENDA	2.1.3.3. 435.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_THEAC

Accession

Primary (citable) accession number: Q9HIK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	July 11, 2003
Last modified:	February 9, 2010
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)