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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciTACI273075:G1GT7-1482-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Ta1357
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001670331 – 472Probable glycine dehydrogenase (decarboxylating) subunit 2Add BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei268N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi273075.Ta1357

Structurei

3D structure databases

ProteinModelPortaliQ9HII2
SMRiQ9HII2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00076 Archaea
COG1003 LUCA
HOGENOMiHOG000239368
KOiK00283
OMAiMHINLHK
OrthoDBiPOG093Z01WJ

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00713 GcvPB, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR023012 GcvPB
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HII2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFRQAYYDE PLIKDIKSDT SFKLSEDVDE NLLPQDMRRT DLKLPQVSEV
60 70 80 90 100
DVVRHYTRLS QMNYTVDVGI YPLGSCTMKY NPKYADRIAS FAEFRNIHPF
110 120 130 140 150
QPESTVQGTL QIMYELQEFL KKISDMDAVT LQPMAGADGE FTGILIIKKY
160 170 180 190 200
FEDLHEDRTE IIVPDSAHGT NPASATMGGF DVVEIPSNSE GMVDLNALKA
210 220 230 240 250
AISKKTAALM ITNPNTLGIF EQNITEIAKI LHDAGALLYY DGANLNAIFG
260 270 280 290 300
ITSPGLMGFD IVHFNLHKSF ATPHGGGGPG AGPVAVKSFL SDFLPVPVVG
310 320 330 340 350
YDGKRYFLDY GKKKSIGRVS SFYGSFSILL RAWSYVIRNG DDGLKNATIR
360 370 380 390 400
AVLNSNYLKK KVEGYYEVPY YPLKKHEFVL STEKTGRRAL DIGKYLLDFG
410 420 430 440 450
IHSPTVYFPL IVKEAMMIEP TETVSKDDLD RYADVLISAL KVPEDDLKSR
460 470
PRNTAVSRID EVKAARDLKV RW
Length:472
Mass (Da):52,839
Last modified:March 1, 2001 - v1
Checksum:iF964E65C0517D872
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445067 Genomic DNA Translation: CAC12478.1
RefSeqiWP_010901764.1, NC_002578.1

Genome annotation databases

EnsemblBacteriaiCAC12478; CAC12478; CAC12478
GeneIDi1456828
KEGGitac:Ta1357

Similar proteinsi

Entry informationi

Entry nameiGCSPB_THEAC
AccessioniPrimary (citable) accession number: Q9HII2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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