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Q9HII1 (GCSPA_THEAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Ta1358
OrganismThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) [Reference proteome] [HAMAP]
Taxonomic identifier273075 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_0000166991

Sequences

Sequence LengthMass (Da)Tools
Q9HII1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: B0BAFDFA6E3722AB

FASTA43347,937
        10         20         30         40         50         60 
MDELLSMLNF LGMKDPEELF SDIPKSVRKK SIGIGGGLDE YRVIDRAMEI GRKNKTDMIN 

        70         80         90        100        110        120 
FLGNGIYDRV IPEAVNYILS KPEFLDSYTP YQPEISQGML QSMFEYQSLI SDLMGMDVTN 

       130        140        150        160        170        180 
ASMYDGYSAL GEAARMAYRI NGHSKILVPE SSYDSKISVL RNYIWGLNMK IMKYRIGEDG 

       190        200        210        220        230        240 
MIDLDDLSSK IDSDTSAIVV ENPNGYGILD KNIFGVKDIK KDAVLISYVD PISLGVVKPP 

       250        260        270        280        290        300 
GEYGSDIAVA EGQQLGIPMN FGGPLLGLMS FKMEHIRRSP GRIIGESIDS NGKRAYVMTL 

       310        320        330        340        350        360 
QTREQHIRRA KATSNICSNQ ALLTLAASAY LSIMGSTGLR KVALLTIKHS RMIKEKLSSI 

       370        380        390        400        410        420 
GVKPYFSTES FSDVMFRLER DVMEALASKN ILGGLKLRQL ISDTPMKDAT FFTVTEKTDA 

       430 
AAIEKLAAAL EVI 

« Hide

References

[1]"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL445067 Genomic DNA. Translation: CAC12479.1.
RefSeqNP_394814.1. NC_002578.1.

3D structure databases

ProteinModelPortalQ9HII1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273075.Ta1358.

Proteomic databases

PRIDEQ9HII1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC12479; CAC12479; CAC12479.
GeneID1456829.
KEGGtac:Ta1358.

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMARLVGQTE.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_THEAC
AccessionPrimary (citable) accession number: Q9HII1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families