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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciTACI273075:G1GT7-1483-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Ta1358
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669911 – 433Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST433

Proteomic databases

PRIDEiQ9HII1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi273075.Ta1358

Structurei

3D structure databases

ProteinModelPortaliQ9HII1
SMRiQ9HII1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00077 Archaea
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG093Z02N9

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HII1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDELLSMLNF LGMKDPEELF SDIPKSVRKK SIGIGGGLDE YRVIDRAMEI
60 70 80 90 100
GRKNKTDMIN FLGNGIYDRV IPEAVNYILS KPEFLDSYTP YQPEISQGML
110 120 130 140 150
QSMFEYQSLI SDLMGMDVTN ASMYDGYSAL GEAARMAYRI NGHSKILVPE
160 170 180 190 200
SSYDSKISVL RNYIWGLNMK IMKYRIGEDG MIDLDDLSSK IDSDTSAIVV
210 220 230 240 250
ENPNGYGILD KNIFGVKDIK KDAVLISYVD PISLGVVKPP GEYGSDIAVA
260 270 280 290 300
EGQQLGIPMN FGGPLLGLMS FKMEHIRRSP GRIIGESIDS NGKRAYVMTL
310 320 330 340 350
QTREQHIRRA KATSNICSNQ ALLTLAASAY LSIMGSTGLR KVALLTIKHS
360 370 380 390 400
RMIKEKLSSI GVKPYFSTES FSDVMFRLER DVMEALASKN ILGGLKLRQL
410 420 430
ISDTPMKDAT FFTVTEKTDA AAIEKLAAAL EVI
Length:433
Mass (Da):47,937
Last modified:March 1, 2001 - v1
Checksum:iB0BAFDFA6E3722AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445067 Genomic DNA Translation: CAC12479.1
RefSeqiWP_010901765.1, NC_002578.1

Genome annotation databases

EnsemblBacteriaiCAC12479; CAC12479; CAC12479
GeneIDi1456829
KEGGitac:Ta1358

Similar proteinsi

Entry informationi

Entry nameiGCSPA_THEAC
AccessioniPrimary (citable) accession number: Q9HII1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health