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Q9HI67

- FTHS_THEAC

UniProt

Q9HI67 - FTHS_THEAC

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi51 – 588ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Ta1478
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001024: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Formate--tetrahydrofolate ligasePRO_0000199415Add
BLAST

Proteomic databases

PRIDEiQ9HI67.

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta1478.

Structurei

3D structure databases

ProteinModelPortaliQ9HI67.
SMRiQ9HI67. Positions 1-534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HI67-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRDIEEIIKE IGLGRDDYEL YGRYMAKLDL GLQNRGRPRA KLILVTAMTP
60 70 80 90 100
TPAGEGKTTT TIGLGQAMKK LGKNVAIAIR EPSLGPCFGI KGGATGGGKS
110 120 130 140 150
KVEPSDRINL FFTGDFPTIT AAHNLLSAMI NNHMYHGNEL NLDPKRITFP
160 170 180 190 200
RTIDMNDRSL RSILVGVGPR DMGVLAGDSF VITPASEVMA ITGLSLNYQD
210 220 230 240 250
LKARLSRILA GFTTKNKPVF AGDLKAEGSM AALLRDALKP NLVQTTEGVP
260 270 280 290 300
AFVHTGPFGN IAHGTSSLVA DKIALNLFDY VITEAGFGSD LGAEKFFNLA
310 320 330 340 350
SRIGDLPINA VVLVATIRAI KHHGGSKKEG EDIDAVKTGS KNLIRHVQNI
360 370 380 390 400
RNFGIDPVVA VNRFPTDTDG EIRALGEILD SNGIKWALSE VFAKGGEGGI
410 420 430 440 450
DLANKVLASL GSHEIKRTYD LKDDIRTKIE KIARNVYGAD GVIFEKKALS
460 470 480 490 500
DMKKAEEIME NPYVCMAKTQ YSFSDDASLL NDPHGFTIKV QSINISSGAG
510 520 530
FVVPILGEIM TMPGLPKHPA AENIDLTDSG EITGLF
Length:536
Mass (Da):57,647
Last modified:March 1, 2001 - v1
Checksum:i82D0405ABA148E7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445067 Genomic DNA. Translation: CAC12596.1.
RefSeqiNP_394929.1. NC_002578.1.
WP_010901878.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC12596; CAC12596; CAC12596.
GeneIDi1456930.
KEGGitac:Ta1478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445067 Genomic DNA. Translation: CAC12596.1 .
RefSeqi NP_394929.1. NC_002578.1.
WP_010901878.1. NC_002578.1.

3D structure databases

ProteinModelPortali Q9HI67.
SMRi Q9HI67. Positions 1-534.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273075.Ta1478.

Proteomic databases

PRIDEi Q9HI67.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC12596 ; CAC12596 ; CAC12596 .
GeneIDi 1456930.
KEGGi tac:Ta1478.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
    Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
    Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Entry informationi

Entry nameiFTHS_THEAC
AccessioniPrimary (citable) accession number: Q9HI67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2001
Last modified: October 1, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3