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Q9HI67

- FTHS_THEAC

UniProt

Q9HI67 - FTHS_THEAC

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi51 – 588ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Ta1478
    OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
    Taxonomic identifieri273075 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
    ProteomesiUP000001024: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 536536Formate--tetrahydrofolate ligasePRO_0000199415Add
    BLAST

    Proteomic databases

    PRIDEiQ9HI67.

    Interactioni

    Protein-protein interaction databases

    STRINGi273075.Ta1478.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HI67.
    SMRiQ9HI67. Positions 1-534.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HI67-1 [UniParc]FASTAAdd to Basket

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    MRDIEEIIKE IGLGRDDYEL YGRYMAKLDL GLQNRGRPRA KLILVTAMTP    50
    TPAGEGKTTT TIGLGQAMKK LGKNVAIAIR EPSLGPCFGI KGGATGGGKS 100
    KVEPSDRINL FFTGDFPTIT AAHNLLSAMI NNHMYHGNEL NLDPKRITFP 150
    RTIDMNDRSL RSILVGVGPR DMGVLAGDSF VITPASEVMA ITGLSLNYQD 200
    LKARLSRILA GFTTKNKPVF AGDLKAEGSM AALLRDALKP NLVQTTEGVP 250
    AFVHTGPFGN IAHGTSSLVA DKIALNLFDY VITEAGFGSD LGAEKFFNLA 300
    SRIGDLPINA VVLVATIRAI KHHGGSKKEG EDIDAVKTGS KNLIRHVQNI 350
    RNFGIDPVVA VNRFPTDTDG EIRALGEILD SNGIKWALSE VFAKGGEGGI 400
    DLANKVLASL GSHEIKRTYD LKDDIRTKIE KIARNVYGAD GVIFEKKALS 450
    DMKKAEEIME NPYVCMAKTQ YSFSDDASLL NDPHGFTIKV QSINISSGAG 500
    FVVPILGEIM TMPGLPKHPA AENIDLTDSG EITGLF 536
    Length:536
    Mass (Da):57,647
    Last modified:March 1, 2001 - v1
    Checksum:i82D0405ABA148E7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445067 Genomic DNA. Translation: CAC12596.1.
    RefSeqiNP_394929.1. NC_002578.1.
    WP_010901878.1. NC_002578.1.

    Genome annotation databases

    EnsemblBacteriaiCAC12596; CAC12596; CAC12596.
    GeneIDi1456930.
    KEGGitac:Ta1478.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445067 Genomic DNA. Translation: CAC12596.1 .
    RefSeqi NP_394929.1. NC_002578.1.
    WP_010901878.1. NC_002578.1.

    3D structure databases

    ProteinModelPortali Q9HI67.
    SMRi Q9HI67. Positions 1-534.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273075.Ta1478.

    Proteomic databases

    PRIDEi Q9HI67.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC12596 ; CAC12596 ; CAC12596 .
    GeneIDi 1456930.
    KEGGi tac:Ta1478.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
      Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
      Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

    Entry informationi

    Entry nameiFTHS_THEAC
    AccessioniPrimary (citable) accession number: Q9HI67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3