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Q9HI67 (FTHS_THEAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Ta1478
OrganismThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) [Reference proteome] [HAMAP]
Taxonomic identifier273075 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length536 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 536536Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199415

Regions

Nucleotide binding51 – 588ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HI67 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 82D0405ABA148E7C

FASTA53657,647
        10         20         30         40         50         60 
MRDIEEIIKE IGLGRDDYEL YGRYMAKLDL GLQNRGRPRA KLILVTAMTP TPAGEGKTTT 

        70         80         90        100        110        120 
TIGLGQAMKK LGKNVAIAIR EPSLGPCFGI KGGATGGGKS KVEPSDRINL FFTGDFPTIT 

       130        140        150        160        170        180 
AAHNLLSAMI NNHMYHGNEL NLDPKRITFP RTIDMNDRSL RSILVGVGPR DMGVLAGDSF 

       190        200        210        220        230        240 
VITPASEVMA ITGLSLNYQD LKARLSRILA GFTTKNKPVF AGDLKAEGSM AALLRDALKP 

       250        260        270        280        290        300 
NLVQTTEGVP AFVHTGPFGN IAHGTSSLVA DKIALNLFDY VITEAGFGSD LGAEKFFNLA 

       310        320        330        340        350        360 
SRIGDLPINA VVLVATIRAI KHHGGSKKEG EDIDAVKTGS KNLIRHVQNI RNFGIDPVVA 

       370        380        390        400        410        420 
VNRFPTDTDG EIRALGEILD SNGIKWALSE VFAKGGEGGI DLANKVLASL GSHEIKRTYD 

       430        440        450        460        470        480 
LKDDIRTKIE KIARNVYGAD GVIFEKKALS DMKKAEEIME NPYVCMAKTQ YSFSDDASLL 

       490        500        510        520        530 
NDPHGFTIKV QSINISSGAG FVVPILGEIM TMPGLPKHPA AENIDLTDSG EITGLF 

« Hide

References

[1]"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL445067 Genomic DNA. Translation: CAC12596.1.
RefSeqNP_394929.1. NC_002578.1.

3D structure databases

ProteinModelPortalQ9HI67.
SMRQ9HI67. Positions 1-534.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273075.Ta1478.

Proteomic databases

PRIDEQ9HI67.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC12596; CAC12596; CAC12596.
GeneID1456930.
KEGGtac:Ta1478.

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
ProtClustDBCLSK228062.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_THEAC
AccessionPrimary (citable) accession number: Q9HI67
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways