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Q9HI67

- FTHS_THEAC

UniProt

Q9HI67 - FTHS_THEAC

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Ta1478
Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi51 – 588ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Ta1478
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001024: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199415Add
BLAST

Proteomic databases

PRIDEiQ9HI67.

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta1478.

Structurei

3D structure databases

ProteinModelPortaliQ9HI67.
SMRiQ9HI67. Positions 1-534.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HI67-1 [UniParc]FASTAAdd to Basket

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MRDIEEIIKE IGLGRDDYEL YGRYMAKLDL GLQNRGRPRA KLILVTAMTP    50
TPAGEGKTTT TIGLGQAMKK LGKNVAIAIR EPSLGPCFGI KGGATGGGKS 100
KVEPSDRINL FFTGDFPTIT AAHNLLSAMI NNHMYHGNEL NLDPKRITFP 150
RTIDMNDRSL RSILVGVGPR DMGVLAGDSF VITPASEVMA ITGLSLNYQD 200
LKARLSRILA GFTTKNKPVF AGDLKAEGSM AALLRDALKP NLVQTTEGVP 250
AFVHTGPFGN IAHGTSSLVA DKIALNLFDY VITEAGFGSD LGAEKFFNLA 300
SRIGDLPINA VVLVATIRAI KHHGGSKKEG EDIDAVKTGS KNLIRHVQNI 350
RNFGIDPVVA VNRFPTDTDG EIRALGEILD SNGIKWALSE VFAKGGEGGI 400
DLANKVLASL GSHEIKRTYD LKDDIRTKIE KIARNVYGAD GVIFEKKALS 450
DMKKAEEIME NPYVCMAKTQ YSFSDDASLL NDPHGFTIKV QSINISSGAG 500
FVVPILGEIM TMPGLPKHPA AENIDLTDSG EITGLF 536
Length:536
Mass (Da):57,647
Last modified:March 1, 2001 - v1
Checksum:i82D0405ABA148E7C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445067 Genomic DNA. Translation: CAC12596.1.
RefSeqiNP_394929.1. NC_002578.1.
WP_010901878.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC12596; CAC12596; CAC12596.
GeneIDi1456930.
KEGGitac:Ta1478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445067 Genomic DNA. Translation: CAC12596.1 .
RefSeqi NP_394929.1. NC_002578.1.
WP_010901878.1. NC_002578.1.

3D structure databases

ProteinModelPortali Q9HI67.
SMRi Q9HI67. Positions 1-534.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273075.Ta1478.

Proteomic databases

PRIDEi Q9HI67.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC12596 ; CAC12596 ; CAC12596 .
GeneIDi 1456930.
KEGGi tac:Ta1478.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
    Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
    Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Entry informationi

Entry nameiFTHS_THEAC
AccessioniPrimary (citable) accession number: Q9HI67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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