Q9HHN2 (SYR_HALSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	VNG_6312G

Encoded on

Plasmid pNRC200

Organism

Halobacterium salinarium (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)

Taxonomic identifier

64091 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium

Protein attributes

Sequence length	631 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subcellular location	Cytoplasm HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome Plasmid Reference proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 631	631	Arginine--tRNA ligase HAMAP MF_00123		PRO_0000151644
Regions
	Motif	132 – 142	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q9HHN2 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 1BF5F0A47AF1B30E	FASTA	631	70,471
	10 20 30 40 50 60 MLYNLRQELL AGIRAATSDA GYDYEVDQSA IELEDITDEE KGEFSSPISF SIAAAAGAPP 70 80 90 100 110 120 VDVAAAIADA HRSNGLPAEV EAVTVEGGHI NYHADTTDLA DATLSTILRD GSEYGTRTDA 130 140 150 160 170 180 DPDTILADVS SPNIAKPLHV GHLRNTILSD AVMNILEARG HDVTRDNHLG DWGVQFGNLM 190 200 210 220 230 240 HEYTEFGDEA TLEDDAIEHL LDLYQQFEQR DSMLADLEDD ETVTDQFADA VTEERDYHAD 250 260 270 280 290 300 SGKEWFTRLE QGDEDATALW ERFRTVSIDR FKQTYDDLDV AFDVWNGESF YAQEGWNDVI 310 320 330 340 350 360 IEKAIENDVA MRGEGESVYI PVYPDDYENV GDPQAADVDA SLDRARQMRE ANDDLEDADF 370 380 390 400 410 420 DPFYIVKSDG STLYGTRDLA TIEYRIEEYD ADQSVYVVAN EQNQYFQQLF VAARKMGYND 430 440 450 460 470 480 IKLKHIDYGL ISLPEGSMST RKGQIITARE VLDRAQDRAE EIIAEKGRID DAEAQSVATK 490 500 510 520 530 540 IALATIKYEM VAAKRERDTT FDIDESVALE GDTGPYVQYA ATRGYSILDG ADAAPEIDDL 550 560 570 580 590 600 DPSVFNDTDV ELLFELARYP LVLERCEERY DAAPLAHYLL QLAHVFNSFY HKNAVLDAEN 610 620 630 ARTERLLLTK ATTQIFDNGL GLLGIDVLEE M

References

[1]

"Genome sequence of Halobacterium species NRC-1." Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K. , Cruz R., Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S. Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000) [PubMed: 11016950] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700922 / JCM 11081 / NRC-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004438 Genomic DNA. Translation: AAG20944.1.
RefSeq	NP_395809.1. NC_002608.1.
3D structure databases
ProteinModelPortal	Q9HHN2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1449192.
GenomeReviews	Gene locus VNG_6312G in contig AE004438_GR.
KEGG	hal:VNG6312G.
NMPDR	fig|64091.1.peg.2493.
Phylogenomic databases
HOGENOM	HBG695395.
OMA	FHEEAEK.
PhylomeDB	Q9HHN2.
ProtClustDB	CLSK2301553.
Enzyme and pathway databases
BioCyc	HSP64091:VNG6312G-MONOMER.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 2 hits.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 2 hits. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_HALSA

Accession

Primary (citable) accession number: Q9HHN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program