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Protein

Tritrans,polycis-undecaprenyl-diphosphate synthase (GGDP specific)

Gene

uppS

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Generates tritrans,heptacis-undecaprenyl diphosphate from isopentenyl pyrophosphate (IPP) and geranylgeranyl diphosphate. It is probably the precursor of glycosyl carrier lipids.

Catalytic activityi

Geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate.1 Publication

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401By similarity
Metal bindingi40 – 401MagnesiumBy similarity
Binding sitei45 – 451SubstrateBy similarity
Active sitei88 – 881Proton acceptorBy similarity
Binding sitei92 – 921SubstrateBy similarity
Binding sitei211 – 2111SubstrateBy similarity
Metal bindingi230 – 2301MagnesiumBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15683.
SACI330779:GH9J-745-MONOMER.
BRENDAi2.5.1.89. 6160.

Names & Taxonomyi

Protein namesi
Recommended name:
Tritrans,polycis-undecaprenyl-diphosphate synthase (GGDP specific) (EC:2.5.1.89)
Alternative name(s):
Undecaprenyl diphosphate synthase
Short name:
UDS
Undecaprenyl pyrophosphate synthase
Short name:
UPP synthase
Gene namesi
Name:uppS
Synonyms:cpdS
Ordered Locus Names:Saci_0757
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Tritrans,polycis-undecaprenyl-diphosphate synthase (GGDP specific)PRO_0000123741Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi330779.Saci_0757.

Structurei

3D structure databases

ProteinModelPortaliQ9HH76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 444Substrate bindingBy similarity
Regioni85 – 873Substrate bindingBy similarity
Regioni217 – 2193Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the UPP synthase family.Curated

Phylogenomic databases

eggNOGiarCOG01532. Archaea.
COG0020. LUCA.
HOGENOMiHOG000006056.
KOiK15888.
OMAiWAKLKNK.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HH76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDVITRAL LRPIYKIYEK ILWSQIKDGP FPFHVGIIPD GNRRWARNNR
60 70 80 90 100
LPLDQGYYTG YVKLRDVLTW ILEIGISTVT VFALSAENCE KRTQQELSMI
110 120 130 140 150
FKYLKIGLDE LLTSDLVHKY QVRVKAIGML DKLPEDLKKL VVDLESTTEK
160 170 180 190 200
YNKKKLILAI CYGGRQEILD AIRKIMNDYK LGIIDSKSID ESTFRKYLYD
210 220 230 240 250
QELSDIDLLI RSSGEIRISN FLLWHLAYSE LFFVDVYWPD FRKIDLWRAI
260
RSFQKRKRNF GA
Length:262
Mass (Da):30,871
Last modified:March 1, 2001 - v1
Checksum:iC1D3C384A4E0263C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048249 Genomic DNA. Translation: BAB12723.1.
CP000077 Genomic DNA. Translation: AAY80133.1.
RefSeqiWP_011277635.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY80133; AAY80133; Saci_0757.
GeneIDi3473288.
KEGGisai:Saci_0757.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048249 Genomic DNA. Translation: BAB12723.1.
CP000077 Genomic DNA. Translation: AAY80133.1.
RefSeqiWP_011277635.1. NC_007181.1.

3D structure databases

ProteinModelPortaliQ9HH76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330779.Saci_0757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY80133; AAY80133; Saci_0757.
GeneIDi3473288.
KEGGisai:Saci_0757.

Phylogenomic databases

eggNOGiarCOG01532. Archaea.
COG0020. LUCA.
HOGENOMiHOG000006056.
KOiK15888.
OMAiWAKLKNK.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15683.
SACI330779:GH9J-745-MONOMER.
BRENDAi2.5.1.89. 6160.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUPPS_SULAC
AccessioniPrimary (citable) accession number: Q9HH76
Secondary accession number(s): Q4JAP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.