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Q9HH09

- GLNA_SULAC

UniProt

Q9HH09 - GLNA_SULAC

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Protein
Glutamine synthetase
Gene
glnA, Saci_1483
Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSACI330779:GH9J-1458-MONOMER.
BRENDAi6.3.1.2. 6160.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:Saci_1483
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001018: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Glutamine synthetase
PRO_0000153213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei402 – 4021O-AMP-tyrosine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Dodecamer.

Protein-protein interaction databases

STRINGi330779.Saci_1483.

Structurei

3D structure databases

ProteinModelPortaliQ9HH09.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005157.
KOiK01915.
OMAiVHAWEIE.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HH09-1 [UniParc]FASTAAdd to Basket

« Hide

MPGLPKNEHE ALEFLKSNNI KWVDLQFTDL LGKLQHITIP SNEFDESSFK    50
VGFGKLDGSS IKGFTSIYES DMVLLPIPQT MTLIPWMQGV ARVLTKVFWG 100
GGKGRFERDP RGIAEEAEKY QSEQGYVSYF GPELEFFVFD KVEVDASLPQ 150
SGTGYKIHSR EAPWSKNGGY VIRYKEGYYP ASPVDQLMDI RLEIISTLVD 200
YFGFTIEAAH HEVATAGQGE IDFRFSTLAD TADKVQVLKY VTKNIASKRG 250
MIATFMPKPF FGDNGSGMHT HFSLWTKDGK NLMYDPNDEY AELSQIGRYI 300
IGGLLEHGRA LSAIVAPTTN SYRRLVPGYE APVYLVWSKS NRSAAIRIPA 350
YYKGMEKAKR LEYRPPDPSS NPYLVFSAIL MAGLDGIRRK LDPGDPVDEN 400
IYHMSEEKKR SLKIRELPGS LDEALNELES DNEFLKPVFN SSILQAYLDL 450
KKEEAKMMQL YPHPMEIYQY LDS 473
Length:473
Mass (Da):53,586
Last modified:August 30, 2005 - v2
Checksum:iF8EA4FD71B1CDD5D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851D → V in CAC20905. 1 Publication
Sequence conflicti204 – 2074FTIE → TIEA1 Publication
Sequence conflicti209 – 2091A → H1 Publication
Sequence conflicti211 – 25949HEVAT…FMPKP → EVATAGQGDIDFRFSTLADT ADKVQVLKYVTKNIASKRGM IATFMPKPF1 Publication
Add
BLAST
Sequence conflicti261 – 29939FGDNG…QIGRY → GDNGSGMHTHFSLWTKDGKN LMYDPNDEYAELSQIGRYI1 Publication
Add
BLAST
Sequence conflicti301 – 3033IGG → GPL1 Publication
Sequence conflicti305 – 31410LEHGRALSAI → EHGRALSAIV1 Publication
Sequence conflicti317 – 3171P → G1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ224678 Genomic DNA. Translation: CAC20905.1.
CP000077 Genomic DNA. Translation: AAY80804.1.
RefSeqiYP_256097.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY80804; AAY80804; Saci_1483.
GeneIDi3474677.
KEGGisai:Saci_1483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ224678 Genomic DNA. Translation: CAC20905.1 .
CP000077 Genomic DNA. Translation: AAY80804.1 .
RefSeqi YP_256097.1. NC_007181.1.

3D structure databases

ProteinModelPortali Q9HH09.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 330779.Saci_1483.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY80804 ; AAY80804 ; Saci_1483 .
GeneIDi 3474677.
KEGGi sai:Saci_1483.

Phylogenomic databases

eggNOGi COG0174.
HOGENOMi HOG000005157.
KOi K01915.
OMAi VHAWEIE.

Enzyme and pathway databases

BioCyci SACI330779:GH9J-1458-MONOMER.
BRENDAi 6.3.1.2. 6160.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The glutamine synthetase from the hyperthermoacidophilic crenarcheon Sulfolobus acidocaldarius: isolation, characterization and sequencing of the gene."
    Yin Z.M., Purschke W.G., Schaefer G., Schmidt C.L.
    Biol. Chem. 379:1349-1354(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.
  2. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiGLNA_SULAC
AccessioniPrimary (citable) accession number: Q9HH09
Secondary accession number(s): Q4J8S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: August 30, 2005
Last modified: September 3, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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