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Q9HH09

- GLNA_SULAC

UniProt

Q9HH09 - GLNA_SULAC

Protein

Glutamine synthetase

Gene

glnA

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    Enzyme regulationi

    The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine biosynthetic process Source: InterPro
    2. nitrogen fixation Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSACI330779:GH9J-1458-MONOMER.
    BRENDAi6.3.1.2. 6160.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase (EC:6.3.1.2)
    Short name:
    GS
    Alternative name(s):
    Glutamate--ammonia ligase
    Gene namesi
    Name:glnA
    Ordered Locus Names:Saci_1483
    OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
    Taxonomic identifieri330779 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001018: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 473473Glutamine synthetasePRO_0000153213Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei402 – 4021O-AMP-tyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Dodecamer.

    Protein-protein interaction databases

    STRINGi330779.Saci_1483.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HH09.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Phylogenomic databases

    eggNOGiCOG0174.
    HOGENOMiHOG000005157.
    KOiK01915.
    OMAiVHAWEIE.

    Family and domain databases

    Gene3Di3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    TIGRFAMsiTIGR00653. GlnA. 1 hit.
    PROSITEiPS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HH09-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGLPKNEHE ALEFLKSNNI KWVDLQFTDL LGKLQHITIP SNEFDESSFK    50
    VGFGKLDGSS IKGFTSIYES DMVLLPIPQT MTLIPWMQGV ARVLTKVFWG 100
    GGKGRFERDP RGIAEEAEKY QSEQGYVSYF GPELEFFVFD KVEVDASLPQ 150
    SGTGYKIHSR EAPWSKNGGY VIRYKEGYYP ASPVDQLMDI RLEIISTLVD 200
    YFGFTIEAAH HEVATAGQGE IDFRFSTLAD TADKVQVLKY VTKNIASKRG 250
    MIATFMPKPF FGDNGSGMHT HFSLWTKDGK NLMYDPNDEY AELSQIGRYI 300
    IGGLLEHGRA LSAIVAPTTN SYRRLVPGYE APVYLVWSKS NRSAAIRIPA 350
    YYKGMEKAKR LEYRPPDPSS NPYLVFSAIL MAGLDGIRRK LDPGDPVDEN 400
    IYHMSEEKKR SLKIRELPGS LDEALNELES DNEFLKPVFN SSILQAYLDL 450
    KKEEAKMMQL YPHPMEIYQY LDS 473
    Length:473
    Mass (Da):53,586
    Last modified:August 30, 2005 - v2
    Checksum:iF8EA4FD71B1CDD5D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti185 – 1851D → V in CAC20905. (PubMed:9865608)Curated
    Sequence conflicti204 – 2074FTIE → TIEA(PubMed:9865608)Curated
    Sequence conflicti209 – 2091A → H(PubMed:9865608)Curated
    Sequence conflicti211 – 25949HEVAT…FMPKP → EVATAGQGDIDFRFSTLADT ADKVQVLKYVTKNIASKRGM IATFMPKPF(PubMed:9865608)CuratedAdd
    BLAST
    Sequence conflicti261 – 29939FGDNG…QIGRY → GDNGSGMHTHFSLWTKDGKN LMYDPNDEYAELSQIGRYI(PubMed:9865608)CuratedAdd
    BLAST
    Sequence conflicti301 – 3033IGG → GPL(PubMed:9865608)Curated
    Sequence conflicti305 – 31410LEHGRALSAI → EHGRALSAIV(PubMed:9865608)Curated
    Sequence conflicti317 – 3171P → G(PubMed:9865608)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ224678 Genomic DNA. Translation: CAC20905.1.
    CP000077 Genomic DNA. Translation: AAY80804.1.
    RefSeqiYP_256097.1. NC_007181.1.

    Genome annotation databases

    EnsemblBacteriaiAAY80804; AAY80804; Saci_1483.
    GeneIDi3474677.
    KEGGisai:Saci_1483.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ224678 Genomic DNA. Translation: CAC20905.1 .
    CP000077 Genomic DNA. Translation: AAY80804.1 .
    RefSeqi YP_256097.1. NC_007181.1.

    3D structure databases

    ProteinModelPortali Q9HH09.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 330779.Saci_1483.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY80804 ; AAY80804 ; Saci_1483 .
    GeneIDi 3474677.
    KEGGi sai:Saci_1483.

    Phylogenomic databases

    eggNOGi COG0174.
    HOGENOMi HOG000005157.
    KOi K01915.
    OMAi VHAWEIE.

    Enzyme and pathway databases

    BioCyci SACI330779:GH9J-1458-MONOMER.
    BRENDAi 6.3.1.2. 6160.

    Family and domain databases

    Gene3Di 3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    TIGRFAMsi TIGR00653. GlnA. 1 hit.
    PROSITEi PS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The glutamine synthetase from the hyperthermoacidophilic crenarcheon Sulfolobus acidocaldarius: isolation, characterization and sequencing of the gene."
      Yin Z.M., Purschke W.G., Schaefer G., Schmidt C.L.
      Biol. Chem. 379:1349-1354(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
      Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.
    2. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
      Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
      J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

    Entry informationi

    Entry nameiGLNA_SULAC
    AccessioniPrimary (citable) accession number: Q9HH09
    Secondary accession number(s): Q4J8S1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3