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Q9HH09

- GLNA_SULAC

UniProt

Q9HH09 - GLNA_SULAC

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Protein

Glutamine synthetase

Gene

glnA

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSACI330779:GH9J-1458-MONOMER.
BRENDAi6.3.1.2. 6160.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:Saci_1483
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001018: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Glutamine synthetasePRO_0000153213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei402 – 4021O-AMP-tyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Dodecamer.

Protein-protein interaction databases

STRINGi330779.Saci_1483.

Structurei

3D structure databases

ProteinModelPortaliQ9HH09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005157.
KOiK01915.
OMAiVHAWEIE.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HH09-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGLPKNEHE ALEFLKSNNI KWVDLQFTDL LGKLQHITIP SNEFDESSFK
60 70 80 90 100
VGFGKLDGSS IKGFTSIYES DMVLLPIPQT MTLIPWMQGV ARVLTKVFWG
110 120 130 140 150
GGKGRFERDP RGIAEEAEKY QSEQGYVSYF GPELEFFVFD KVEVDASLPQ
160 170 180 190 200
SGTGYKIHSR EAPWSKNGGY VIRYKEGYYP ASPVDQLMDI RLEIISTLVD
210 220 230 240 250
YFGFTIEAAH HEVATAGQGE IDFRFSTLAD TADKVQVLKY VTKNIASKRG
260 270 280 290 300
MIATFMPKPF FGDNGSGMHT HFSLWTKDGK NLMYDPNDEY AELSQIGRYI
310 320 330 340 350
IGGLLEHGRA LSAIVAPTTN SYRRLVPGYE APVYLVWSKS NRSAAIRIPA
360 370 380 390 400
YYKGMEKAKR LEYRPPDPSS NPYLVFSAIL MAGLDGIRRK LDPGDPVDEN
410 420 430 440 450
IYHMSEEKKR SLKIRELPGS LDEALNELES DNEFLKPVFN SSILQAYLDL
460 470
KKEEAKMMQL YPHPMEIYQY LDS
Length:473
Mass (Da):53,586
Last modified:August 30, 2005 - v2
Checksum:iF8EA4FD71B1CDD5D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851D → V in CAC20905. (PubMed:9865608)Curated
Sequence conflicti204 – 2074FTIE → TIEA(PubMed:9865608)Curated
Sequence conflicti209 – 2091A → H(PubMed:9865608)Curated
Sequence conflicti211 – 25949HEVAT…FMPKP → EVATAGQGDIDFRFSTLADT ADKVQVLKYVTKNIASKRGM IATFMPKPF(PubMed:9865608)CuratedAdd
BLAST
Sequence conflicti261 – 29939FGDNG…QIGRY → GDNGSGMHTHFSLWTKDGKN LMYDPNDEYAELSQIGRYI(PubMed:9865608)CuratedAdd
BLAST
Sequence conflicti301 – 3033IGG → GPL(PubMed:9865608)Curated
Sequence conflicti305 – 31410LEHGRALSAI → EHGRALSAIV(PubMed:9865608)Curated
Sequence conflicti317 – 3171P → G(PubMed:9865608)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224678 Genomic DNA. Translation: CAC20905.1.
CP000077 Genomic DNA. Translation: AAY80804.1.
RefSeqiYP_256097.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY80804; AAY80804; Saci_1483.
GeneIDi3474677.
KEGGisai:Saci_1483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224678 Genomic DNA. Translation: CAC20905.1 .
CP000077 Genomic DNA. Translation: AAY80804.1 .
RefSeqi YP_256097.1. NC_007181.1.

3D structure databases

ProteinModelPortali Q9HH09.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 330779.Saci_1483.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY80804 ; AAY80804 ; Saci_1483 .
GeneIDi 3474677.
KEGGi sai:Saci_1483.

Phylogenomic databases

eggNOGi COG0174.
HOGENOMi HOG000005157.
KOi K01915.
OMAi VHAWEIE.

Enzyme and pathway databases

BioCyci SACI330779:GH9J-1458-MONOMER.
BRENDAi 6.3.1.2. 6160.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The glutamine synthetase from the hyperthermoacidophilic crenarcheon Sulfolobus acidocaldarius: isolation, characterization and sequencing of the gene."
    Yin Z.M., Purschke W.G., Schaefer G., Schmidt C.L.
    Biol. Chem. 379:1349-1354(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.
  2. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiGLNA_SULAC
AccessioniPrimary (citable) accession number: Q9HH09
Secondary accession number(s): Q4J8S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: August 30, 2005
Last modified: October 29, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3