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Protein

Glucose-6-phosphate isomerase

Gene

pgiA

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgiA)
  3. ATP-dependent 6-phosphofructokinase 2 (pfkB), ATP-dependent 6-phosphofructokinase 1 (pfkA)
  4. Fructose-bisphosphate aldolase (fbaA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei363Proton donorBy similarity1
Active sitei394By similarity1
Active sitei516By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgiA
ORF Names:AO090011000659
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001805711 – 553Glucose-6-phosphate isomeraseAdd BLAST553

Proteomic databases

PRIDEiQ9HGZ2

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00005280

Structurei

3D structure databases

ProteinModelPortaliQ9HGZ2
SMRiQ9HGZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

HOGENOMiHOG000261371
KOiK01810
OMAiTNSQHAF
OrthoDBiEOG092C2D1V

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.101 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HGZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAFSQATDL SAWKELQEHH TAVGRNIVLK EAFEKDPQRF EKFSRTFKNT
60 70 80 90 100
VDNSDILFDF SKNFLTEETL SLLVKLAKEA NVEELRDAMF KGEHINFTED
110 120 130 140 150
RAVYHAALRN VSNEPMQVDG KSVVEDVNSV LEHMKEFSEQ VRSGEWKGYT
160 170 180 190 200
DKKIDTIINI GIGGSDLGPV MVTEALKPYG APGMKLHFVS NIDGTHIAEA
210 220 230 240 250
LKDSNPETTL FLIASKTFTT AETTTNANSA KKWFLETAKD ESHIAKHFVA
260 270 280 290 300
LSTNEAEVTK FGIDKKNMFG FESWVGGRYS VWSAIGLSVA LYIGYDNFHQ
310 320 330 340 350
FLAGAQAMDK HFREAPLEQN IPAIGGLLSV WYSDFFGAQT HLVAPFDQYL
360 370 380 390 400
HRFPAYLQQL SMESNGKAIT RSGEYVKYTT GPILFGEPAT NAQHSFFQLL
410 420 430 440 450
HQGTKLIPSD FIMAAESHNP VEGGKHQRML ASNFLAQSEA LMVGKTPEQV
460 470 480 490 500
KTEGAPDNLV PHKTFLGNRP TTSILAQKIT PSTLGALIAY YEHLTFTEGA
510 520 530 540 550
VWNINSFDQW GVELGKVLAK KIQQELETSG AGAGHDASTS GLLAAFKQKA

NLA
Length:553
Mass (Da):61,214
Last modified:March 1, 2001 - v1
Checksum:i06373377B1FF8949
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032269 mRNA Translation: BAB12229.1
AP007171 Genomic DNA Translation: BAE65122.1
RefSeqiXP_001826255.1, XM_001826203.2

Genome annotation databases

EnsemblFungiiBAE65122; BAE65122; AO090011000659
GeneIDi5998358
KEGGiaor:AO090011000659

Similar proteinsi

Entry informationi

Entry nameiG6PI_ASPOR
AccessioniPrimary (citable) accession number: Q9HGZ2
Secondary accession number(s): Q2TZZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: March 1, 2001
Last modified: February 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome