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Q9HGY5

- PHO85_CANAX

UniProt

Q9HGY5 - PHO85_CANAX

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Protein

Negative regulator of the PHO system

Gene
PHO85
Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATP By similarity
Active sitei131 – 1311Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Negative regulator of the PHO system (EC:2.7.11.22)
Alternative name(s):
CaPHO85
Serine/threonine-protein kinase PHO85
Gene namesi
Name:PHO85
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Negative regulator of the PHO systemPRO_0000086516Add
BLAST

Interactioni

Subunit structurei

Interacts with a number of cyclins By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9HGY5.
SMRiQ9HGY5. Positions 8-292.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 290283Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HGY5-1 [UniParc]FASTAAdd to Basket

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MTGSSSQFQQ LEKLGEGTYA TVYKGRNRAT GALVALKEIS LDSEEGTPST    50
AIREISLMKE LDHENIVTLY DVIHTENKLT LVFEYMDKDL KKYMEVHGQQ 100
SALDLKVVKS FMFQLLKGIM FCHDNRVLHR DLKPQNLLIN NKGELKLGDF 150
GLARAFGIPF NTFSNEVVTL WYRAPDVLLG SRAYTTSIDI WSAGCIFAEM 200
CTGKPLFPGT ANEDQLIKIF RLMGTPNERT WPGISQYTNY KNNWQIFVPQ 250
DLRLIVPNLD SMGLNLLQSL LQMRPESRIT ARQALQHPWF HEITMPNAVP 300
QHLSDPYQQQ QQQQQHPHQP IIDQQY 326
Length:326
Mass (Da):37,371
Last modified:March 1, 2001 - v1
Checksum:iDE0FB9D13D1FF4A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033276 Genomic DNA. Translation: BAB12209.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033276 Genomic DNA. Translation: BAB12209.1 .

3D structure databases

ProteinModelPortali Q9HGY5.
SMRi Q9HGY5. Positions 8-292.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0515.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a Candida albicans homologue of the PHO85 gene, a negative regulator of the PHO system in Saccharomyces cerevisiae."
    Miyakawa Y.
    Yeast 16:1045-1051(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPHO85_CANAX
AccessioniPrimary (citable) accession number: Q9HGY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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