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Q9HGY5 (PHO85_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Negative regulator of the PHO system

EC=2.7.11.22
Alternative name(s):
CaPHO85
Serine/threonine-protein kinase PHO85
Gene names
Name:PHO85
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Interacts with a number of cyclins By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Negative regulator of the PHO system
PRO_0000086516

Regions

Domain8 – 290283Protein kinase
Nucleotide binding14 – 229ATP By similarity

Sites

Active site1311Proton acceptor By similarity
Binding site371ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HGY5 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: DE0FB9D13D1FF4A9

FASTA32637,371
        10         20         30         40         50         60 
MTGSSSQFQQ LEKLGEGTYA TVYKGRNRAT GALVALKEIS LDSEEGTPST AIREISLMKE 

        70         80         90        100        110        120 
LDHENIVTLY DVIHTENKLT LVFEYMDKDL KKYMEVHGQQ SALDLKVVKS FMFQLLKGIM 

       130        140        150        160        170        180 
FCHDNRVLHR DLKPQNLLIN NKGELKLGDF GLARAFGIPF NTFSNEVVTL WYRAPDVLLG 

       190        200        210        220        230        240 
SRAYTTSIDI WSAGCIFAEM CTGKPLFPGT ANEDQLIKIF RLMGTPNERT WPGISQYTNY 

       250        260        270        280        290        300 
KNNWQIFVPQ DLRLIVPNLD SMGLNLLQSL LQMRPESRIT ARQALQHPWF HEITMPNAVP 

       310        320 
QHLSDPYQQQ QQQQQHPHQP IIDQQY 

« Hide

References

[1]"Identification of a Candida albicans homologue of the PHO85 gene, a negative regulator of the PHO system in Saccharomyces cerevisiae."
Miyakawa Y.
Yeast 16:1045-1051(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB033276 Genomic DNA. Translation: BAB12209.1.

3D structure databases

ProteinModelPortalQ9HGY5.
SMRQ9HGY5. Positions 8-292.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0515.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePHO85_CANAX
AccessionPrimary (citable) accession number: Q9HGY5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families