Q9HGY5 (PHO85_CANAX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Negative regulator of the PHO system
EC=2.7.11.22

Alternative name(s):
CaPHO85
Serine/threonine-protein kinase PHO85

Gene names

Name:

PHO85

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Interacts with a number of cyclins By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Negative regulator of the PHO system		PRO_0000086516
Regions
	Domain	8 – 290	283	Protein kinase
	Nucleotide binding	14 – 22	9	ATP By similarity
Sites
	Active site	131	1	Proton acceptor By similarity
	Binding site	37	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9HGY5 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: DE0FB9D13D1FF4A9	FASTA	326	37,371
	10 20 30 40 50 60 MTGSSSQFQQ LEKLGEGTYA TVYKGRNRAT GALVALKEIS LDSEEGTPST AIREISLMKE 70 80 90 100 110 120 LDHENIVTLY DVIHTENKLT LVFEYMDKDL KKYMEVHGQQ SALDLKVVKS FMFQLLKGIM 130 140 150 160 170 180 FCHDNRVLHR DLKPQNLLIN NKGELKLGDF GLARAFGIPF NTFSNEVVTL WYRAPDVLLG 190 200 210 220 230 240 SRAYTTSIDI WSAGCIFAEM CTGKPLFPGT ANEDQLIKIF RLMGTPNERT WPGISQYTNY 250 260 270 280 290 300 KNNWQIFVPQ DLRLIVPNLD SMGLNLLQSL LQMRPESRIT ARQALQHPWF HEITMPNAVP 310 320 QHLSDPYQQQ QQQQQHPHQP IIDQQY

References

[1]	"Identification of a Candida albicans homologue of the PHO85 gene, a negative regulator of the PHO system in Saccharomyces cerevisiae." Miyakawa Y. Yeast 16:1045-1051(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB033276 Genomic DNA. Translation: BAB12209.1.
3D structure databases
ProteinModelPortal	Q9HGY5.
SMR	Q9HGY5. Positions 8-292.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG0515.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHO85_CANAX

Accession

Primary (citable) accession number: Q9HGY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	March 1, 2001
Last modified:	May 29, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program