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Q9HGY1

- GPD2_ZYGRO

UniProt

Q9HGY1 - GPD2_ZYGRO

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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)] 2

Gene
GPD2
Organism
Zygosaccharomyces rouxii (Candida mogii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei128 – 1281NAD By similarity
Binding sitei151 – 1511NAD; via amide nitrogen By similarity
Binding sitei151 – 1511Substrate By similarity
Binding sitei184 – 1841NAD; via amide nitrogen By similarity
Active sitei244 – 2441Proton acceptor By similarity
Binding sitei309 – 3091NAD By similarity
Binding sitei338 – 3381NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 456NAD By similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2 (EC:1.1.1.8)
Alternative name(s):
ZrGPD2
Gene namesi
Name:GPD2
OrganismiZygosaccharomyces rouxii (Candida mogii)
Taxonomic identifieri4956 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Glycerol-3-phosphate dehydrogenase [NAD(+)] 2PRO_0000138102Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9HGY1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni309 – 3102Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HGY1-1 [UniParc]FASTAAdd to Basket

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MAATDRLNQT SDILSHSMKK TDTSMSIVTA ENPYKVAVVG SGNWGTTIAK    50
VVAENTKEKP ELFQGRVDMW VFEEQIDGTP LTQIINTKHQ NVKYLPNIDL 100
PGNLVANPDL ISTTKDADVI VFNVPHQFLG RIVSQMKGQI KPDARAISCL 150
KGFEVGPKGV QLLSDYVTQE LGIQCGALSG ANLAPEVAKE HWSETTVAYQ 200
VPDDFKGEGK DIDHRVLKQL FHRPYFHVNV IDDVAGISIA GALKNVVALG 250
CGFVTGLGWG NNAAAAIQRV GLGEIIKFGR MFFPESKVET YYQESAGVAD 300
LITTCSGGRN VRVATEMAKT GKSGEQVEKD ILNGQSAQGL ITAKEVHQWL 350
ESSGHTEEYP LFEAVYQITY ENVPMKELPS MIEELDIVE 389
Length:389
Mass (Da):42,511
Last modified:March 1, 2001 - v1
Checksum:i70BBA9C2AAB463D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB047395 mRNA. Translation: BAB11958.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB047395 mRNA. Translation: BAB11958.1 .

3D structure databases

ProteinModelPortali Q9HGY1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of glycerol-3-phosphate dehydrogenase genes (ZrGPD1 and ZrGPD2) and glycerol dehydrogenase genes (ZrGCY1 and ZrGCY2) from the salt-tolerant yeast Zygosaccharomyces rouxii."
    Iwaki T., Kurono S., Yokose Y., Kubota K., Tamai Y., Watanabe Y.
    Yeast 18:737-744(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ATCC 42981 / IAM 12879 / JCM 22060 / S-96.

Entry informationi

Entry nameiGPD2_ZYGRO
AccessioniPrimary (citable) accession number: Q9HGY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: October 16, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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