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Q9HGU3

- DHE4_NEUSI

UniProt

Q9HGU3 - DHE4_NEUSI

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Protein

NADP-specific glutamate dehydrogenase

Gene
GDH
Organism
Neurospora sitophila (Chrysonilia sitophila)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei114 – 1141 By similarity

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Alternative name(s):
NADP-dependent glutamate dehydrogenase
Gene namesi
Name:GDH
OrganismiNeurospora sitophila (Chrysonilia sitophila)
Taxonomic identifieri40126 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 454453NADP-specific glutamate dehydrogenasePRO_0000182792Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ9HGU3.

Interactioni

Subunit structurei

Homohexamer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9HGU3.
SMRiQ9HGU3. Positions 3-450.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HGU3-1 [UniParc]FASTAAdd to Basket

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MSNLPSEPEF EQAYKELAYT LENSSLFQKH PEYRTALAVA SIPERVIQFR    50
VVWEDDNGNV QVNRGYRVQF NSALGPYKGG LRLHPSVNLS ILKFLGFEQI 100
FKNALTGLSM GGGKGGADFD PKGKSDAEIR RFCCAFMAEL HKHIGADTDV 150
PAGDIGVGGR EIGYMFGAYR KAANRFEGVL TGKGLSWGGS LIRPEATGYG 200
LVYYVGHMLE YSGAGSYAGK RVALSGSGNV AQYAALKLIE LGATVVSLSD 250
SKGALVATGE SGITVEDINA IMAIKEARQS LTTFQHAGHV KWIEGARPWL 300
HVGKVDIALP CATQNEVSKE EAEGLLAAGC KFVAEGSNMG CTLEAIEVFE 350
NNRKEKKGEA VWYAPGKAAN CGGVAVSGLE MAQNSQRLNW TQAEVDEKLK 400
DIMKNAFFNG LNTAKTYAEA AEGELPSLVA GSNIAGFVKV PQAMHDQGDW 450
WSKN 454
Length:454
Mass (Da):48,835
Last modified:January 23, 2007 - v3
Checksum:i5F1DEBDCC9799AEC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285428 mRNA. Translation: AAG01159.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285428 mRNA. Translation: AAG01159.1 .

3D structure databases

ProteinModelPortali Q9HGU3.
SMRi Q9HGU3. Positions 3-450.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9HGU3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Neurospora GDH gene can increase the nitrogen assimilation in transgene tobacco."
    Wang F., Tien P.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiDHE4_NEUSI
AccessioniPrimary (citable) accession number: Q9HGU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 23, 2007
Last modified: October 16, 2013
This is version 55 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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