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Protein

F-actin-capping protein subunit beta

Gene

acp2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Competes with formin cdc12 for attachment to the actin filaments barbed ends. Slowly replaces cdc12 on the barbed ends in preparation for filament disassembly during contractile ring constriction.1 Publication

GO - Molecular functioni

  • actin filament binding Source: PomBase

GO - Biological processi

  • actin cytoskeleton organization Source: InterPro
  • barbed-end actin filament capping Source: PomBase
  • mitotic actomyosin contractile ring contraction Source: PomBase
  • mitotic cytokinesis Source: PomBase
  • negative regulation of actin filament depolymerization Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Actin capping

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-SPO-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
F-actin-capping protein subunit beta
Gene namesi
Name:acp2
ORF Names:SPAC631.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC631.01c.
PomBaseiSPAC631.01c. acp2.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: PomBase
  • actin filament Source: PomBase
  • cell division site Source: PomBase
  • cell tip Source: PomBase
  • cytosol Source: PomBase
  • F-actin capping protein complex Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268F-actin-capping protein subunit betaPRO_0000204641Add
BLAST

Proteomic databases

MaxQBiQ9HGP5.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.1 Publication

GO - Molecular functioni

  • actin filament binding Source: PomBase

Protein-protein interaction databases

BioGridi279812. 41 interactions.
MINTiMINT-4703398.

Structurei

3D structure databases

ProteinModelPortaliQ9HGP5.
SMRiQ9HGP5. Positions 4-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000041208.
InParanoidiQ9HGP5.
KOiK10365.
OMAiFDTYREM.
OrthoDBiEOG78H45S.
PhylomeDBiQ9HGP5.

Family and domain databases

InterProiIPR001698. CAPZB.
IPR019771. F-actin_capping_bsu_CS.
[Graphical view]
PANTHERiPTHR10619. PTHR10619. 1 hit.
PfamiPF01115. F_actin_cap_B. 1 hit.
[Graphical view]
PRINTSiPR00192. FACTINCAPB.
PROSITEiPS00231. F_ACTIN_CAPPING_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HGP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSEDAALDL LRRLNPKDIS KNLDTILSVA PDLADVLLSS VDQPLKVNTC
60 70 80 90 100
SESGNQYLLC DFNRDGDSYR SPWSNKYDPP LEDGLVSTDR VRKLEVSLNE
110 120 130 140 150
AIRVYLDLYY EGGVSSVYLW DQDDSYAGAV LIKKASTSNS SGWDSIHVFE
160 170 180 190 200
CLPTTETNVY DYRLTSTIIL FLSSGSEEQS ALPSKALNLS GHLTRQTSQR
210 220 230 240 250
LPAADDDTEI ANVGKLVEEM ETRMRNFLQD VYFGKTKDII NQTRSIQPVS
260
DAQPNDSALR SVLNDLSI
Length:268
Mass (Da):29,845
Last modified:March 1, 2001 - v1
Checksum:i7E781ADB7B275BEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAC05483.1.
RefSeqiNP_593619.3. NM_001019050.3.

Genome annotation databases

EnsemblFungiiSPAC631.01c.1; SPAC631.01c.1:pep; SPAC631.01c.
GeneIDi2543390.
KEGGispo:SPAC631.01c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAC05483.1.
RefSeqiNP_593619.3. NM_001019050.3.

3D structure databases

ProteinModelPortaliQ9HGP5.
SMRiQ9HGP5. Positions 4-266.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279812. 41 interactions.
MINTiMINT-4703398.

Proteomic databases

MaxQBiQ9HGP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC631.01c.1; SPAC631.01c.1:pep; SPAC631.01c.
GeneIDi2543390.
KEGGispo:SPAC631.01c.

Organism-specific databases

EuPathDBiFungiDB:SPAC631.01c.
PomBaseiSPAC631.01c. acp2.

Phylogenomic databases

HOGENOMiHOG000041208.
InParanoidiQ9HGP5.
KOiK10365.
OMAiFDTYREM.
OrthoDBiEOG78H45S.
PhylomeDBiQ9HGP5.

Enzyme and pathway databases

ReactomeiR-SPO-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

NextBioi20804405.
PROiQ9HGP5.

Family and domain databases

InterProiIPR001698. CAPZB.
IPR019771. F-actin_capping_bsu_CS.
[Graphical view]
PANTHERiPTHR10619. PTHR10619. 1 hit.
PfamiPF01115. F_actin_cap_B. 1 hit.
[Graphical view]
PRINTSiPR00192. FACTINCAPB.
PROSITEiPS00231. F_ACTIN_CAPPING_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast."
    Kovar D.R., Wu J.-Q., Pollard T.D.
    Mol. Biol. Cell 16:2313-2324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCAPZB_SCHPO
AccessioniPrimary (citable) accession number: Q9HGP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.