Reviewed, UniProtKB/Swiss-Prot Q9HGP5 (CAPZB_SCHPO)

Names and origin

Protein names

Recommended name:
    F-actin-capping protein subunit beta

Gene names

Name:	acp2
ORF Names:	SPAC631.01c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Competes with formin cdc12 for attachment to the actin filaments barbed ends. Slowly replaces cdc12 on the barbed ends in preparation for filament disassembly during contractile ring constriction. Ref.2
Subunit structure	Heterodimer of an alpha and a beta subunit. Ref.2
Subcellular location	Cytoplasm › cytoskeleton. Nucleus. Note: Septum. Localizes to cell tips during interphase. Ref.2 Ref.3
Sequence similarities	Belongs to the F-actin-capping protein beta subunit family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Nucleus
Ligand	Actin-binding
Molecular function	Actin capping
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro barbed-end actin filament capping Ref.2 Inferred from direct assay. Source: GeneDB_SPombe cellular protein localization Inferred from genetic interaction. Source: GeneDB_SPombe contractile ring contraction involved in cytokinesis during cell cycle Ref.2 Inferred from genetic interaction. Source: GeneDB_SPombe
Cellular component	F-actin capping protein complex Ref.2 Inferred from direct assay. Source: GeneDB_SPombe actin cortical patch Ref.2 Inferred from direct assay. Source: GeneDB_SPombe actin filament Ref.2 Inferred from direct assay. Source: GeneDB_SPombe cell division site Ref.3 Inferred from direct assay. Source: GeneDB_SPombe cell tip Ref.2 Inferred from direct assay. Source: GeneDB_SPombe cytosol Ref.3 Inferred from direct assay. Source: GeneDB_SPombe nucleus Ref.3 Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	actin filament binding Ref.2 Inferred from direct assay. Source: GeneDB_SPombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	F-actin-capping protein subunit beta		PRO_0000204641

Sequences

	Sequence		Length	Mass (Da)
	Q9HGP5-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 7E781ADB7B275BEE	FASTA	268	29,845
	10 20 30 40 50 60 MNSEDAALDL LRRLNPKDIS KNLDTILSVA PDLADVLLSS VDQPLKVNTC SESGNQYLLC 70 80 90 100 110 120 DFNRDGDSYR SPWSNKYDPP LEDGLVSTDR VRKLEVSLNE AIRVYLDLYY EGGVSSVYLW 130 140 150 160 170 180 DQDDSYAGAV LIKKASTSNS SGWDSIHVFE CLPTTETNVY DYRLTSTIIL FLSSGSEEQS 190 200 210 220 230 240 ALPSKALNLS GHLTRQTSQR LPAADDDTEI ANVGKLVEEM ETRMRNFLQD VYFGKTKDII 250 260 NQTRSIQPVS DAQPNDSALR SVLNDLSI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.
[2]	"Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast." Kovar D.R., Wu J.-Q., Pollard T.D. Mol. Biol. Cell 16:2313-2324(2005) [PubMed: 15743909] [Abstract] Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
[3]	"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329670 Genomic DNA. Translation: CAC05483.1.
RefSeq	NP_593619.3.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9HGP5.
Genome annotation databases
GeneID	2543390.
GenomeReviews	Gene locus acp2 in contig CU329670_GR.
KEGG	spo:SPAC631.01c.
NMPDR	fig|4896.1.peg.3589.
Organism-specific databases
GeneDB_Spombe	SPAC631.01c.
Phylogenomic databases
OMA	YYEGGIS
OrthoDB	EOG9BGBC9
Gene expression databases
ArrayExpress	Q9HGP5.
Family and domain databases
InterPro	IPR019771. F-actin_capping_bsu_CS. IPR001698. Factin_cap_beta. [Graphical view]
PANTHER	PTHR10619. Factin_cap_beta. 1 hit.
Pfam	PF01115. F_actin_cap_B. 1 hit. [Graphical view]
PRINTS	PR00192. FACTINCAPB.
PROSITE	PS00231. F_ACTIN_CAPPING_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAPZB_SCHPO

Accession

Primary (citable) accession number: Q9HGP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	March 1, 2001
Last modified:	November 24, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)