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Protein

Translocation protein sec63

Gene

sec63

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and bip1 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from sec61 may govern the activity of the translocon. sec63 may affect sec61-polypeptide interactions by increasing the affinity of targeting pathways for sec61 and/or by modifying sec61 to allow more efficient polypeptide interaction. May also be involved in SRP-dependent cotranslational translocation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Translocation protein sec63
Gene namesi
Name:sec63
ORF Names:SPBC36B7.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC36B7.03.
PomBaseiSPBC36B7.03. sec63.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010LumenalBy similarity
Transmembranei11 – 3121HelicalSequence analysisAdd
BLAST
Topological domaini32 – 6938CytoplasmicBy similarityAdd
BLAST
Transmembranei70 – 9021HelicalSequence analysisAdd
BLAST
Topological domaini91 – 191101LumenalBy similarityAdd
BLAST
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Topological domaini213 – 611399CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • cell cortex Source: PomBase
  • endoplasmic reticulum Source: PomBase
  • endoplasmic reticulum membrane Source: PomBase
  • integral component of membrane Source: UniProtKB-KW
  • nuclear envelope Source: PomBase
  • nuclear inner membrane Source: UniProtKB-SubCell
  • Sec62/Sec63 complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 611611Translocation protein sec63PRO_0000311762Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei566 – 5661Phosphoserine1 Publication
Modified residuei572 – 5721Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9HGN7.

PTM databases

iPTMnetiQ9HGN7.

Interactioni

Subunit structurei

Component of the heterotetrameric Sec62/63complex composed of sec62, sec63, sec66 and sec72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex. May physically associate with bip1 in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277477. 24 interactions.
MINTiMINT-4703355.

Structurei

3D structure databases

ProteinModelPortaliQ9HGN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 16871JPROSITE-ProRule annotationAdd
BLAST
Domaini200 – 503304SEC63Add
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation
Contains 1 SEC63 domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ9HGN7.
KOiK09540.
OMAiQIKSHYK.
OrthoDBiEOG092C20BT.
PhylomeDBiQ9HGN7.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001623. DnaJ_domain.
IPR014756. Ig_E-set.
IPR004179. Sec63-dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF02889. Sec63. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
SM00973. Sec63. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF81296. SSF81296. 2 hits.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HGN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEYKYDEQ GIFFPVFLLV GTSCCVLPLT YSTILGPSAS KEKKNVRDPF
60 70 80 90 100
QKYRPKDLKV QRKSIFRLRY IFLILGWLAI GFLSYKIANS RLKLNIWDPY
110 120 130 140 150
EILGIAKGTS VDDVRRHYKR LSIKFHPDKV RNMVNTTREE VEKHYIEITN
160 170 180 190 200
AYRALTDDKT RENYALYGTP DVPQHISVGI ALPKWISESE NSIYILGFYG
210 220 230 240 250
LVFGIVLPYA VGKWWYGSRT YTRDHVHVDT VDEWFPKMET SLTLDELLSL
260 270 280 290 300
FASSKELTSL VPNEKNPKEY ILKLLFDHLN RKKTNNFNTH QILSQSDVVL
310 320 330 340 350
NALLSVATAF GFANPVDNVL KLWQHIVQAI PLDAPFPLLQ LPHLLMEDVK
360 370 380 390 400
NLSIRNISSI PQFLSLSEEQ TKDYLPNYSK NQLKEMREIA NGIPRISVVA
410 420 430 440 450
AKVLVDDDEY ITVGAIANLI LDLKCSYGTE VVPEVSTDGT ETATKKDEED
460 470 480 490 500
AEKYHQSKDV VLGDVETLPY AWAPYFTQHH KTAWWIYVVD PRQNRVIVPP
510 520 530 540 550
FSITDIPKTL RTFRIPFQVP PVAGTFSFQL HIMSNSYVGE DVISNLTMIV
560 570 580 590 600
KDTSVLQEQL QEEAVSDLED NSDIDESANA GKDFSDDENI GSDEEDESEY
610
DPMDTDTSDG E
Length:611
Mass (Da):69,726
Last modified:March 1, 2001 - v1
Checksum:iDA4BC288F13514D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAC05724.1.
RefSeqiNP_595985.1. NM_001021892.2.

Genome annotation databases

EnsemblFungiiSPBC36B7.03.1; SPBC36B7.03.1:pep; SPBC36B7.03.
GeneIDi2540961.
KEGGispo:SPBC36B7.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAC05724.1.
RefSeqiNP_595985.1. NM_001021892.2.

3D structure databases

ProteinModelPortaliQ9HGN7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277477. 24 interactions.
MINTiMINT-4703355.

PTM databases

iPTMnetiQ9HGN7.

Proteomic databases

MaxQBiQ9HGN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC36B7.03.1; SPBC36B7.03.1:pep; SPBC36B7.03.
GeneIDi2540961.
KEGGispo:SPBC36B7.03.

Organism-specific databases

EuPathDBiFungiDB:SPBC36B7.03.
PomBaseiSPBC36B7.03. sec63.

Phylogenomic databases

InParanoidiQ9HGN7.
KOiK09540.
OMAiQIKSHYK.
OrthoDBiEOG092C20BT.
PhylomeDBiQ9HGN7.

Enzyme and pathway databases

ReactomeiR-SPO-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

PROiQ9HGN7.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001623. DnaJ_domain.
IPR014756. Ig_E-set.
IPR004179. Sec63-dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF02889. Sec63. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
SM00973. Sec63. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF81296. SSF81296. 2 hits.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEC63_SCHPO
AccessioniPrimary (citable) accession number: Q9HGN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.