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Protein

Translocation protein sec63

Gene

sec63

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and bip1 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from sec61 may govern the activity of the translocon. sec63 may affect sec61-polypeptide interactions by increasing the affinity of targeting pathways for sec61 and/or by modifying sec61 to allow more efficient polypeptide interaction. May also be involved in SRP-dependent cotranslational translocation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-381038 XBP1(S) activates chaperone genes

Names & Taxonomyi

Protein namesi
Recommended name:
Translocation protein sec63
Gene namesi
Name:sec63
ORF Names:SPBC36B7.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC36B7.03
PomBaseiSPBC36B7.03 sec63

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10LumenalBy similarity10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 69CytoplasmicBy similarityAdd BLAST38
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Topological domaini91 – 191LumenalBy similarityAdd BLAST101
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 611CytoplasmicBy similarityAdd BLAST399

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003117621 – 611Translocation protein sec63Add BLAST611

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei566Phosphoserine1 Publication1
Modified residuei572Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9HGN7
PaxDbiQ9HGN7
PRIDEiQ9HGN7

PTM databases

iPTMnetiQ9HGN7

Interactioni

Subunit structurei

Component of the heterotetrameric Sec62/63complex composed of sec62, sec63, sec66 and sec72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex. May physically associate with bip1 in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277477, 24 interactors
STRINGi4896.SPBC36B7.03.1

Structurei

3D structure databases

ProteinModelPortaliQ9HGN7
SMRiQ9HGN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 168JPROSITE-ProRule annotationAdd BLAST71
Domaini200 – 503SEC63Add BLAST304

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ9HGN7
KOiK09540
OMAiSQFDYEM
OrthoDBiEOG092C20BT
PhylomeDBiQ9HGN7

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892 C2_domain_sf
IPR001623 DnaJ_domain
IPR014756 Ig_E-set
IPR036869 J_dom_sf
IPR027137 Sec63
IPR004179 Sec63-dom
PANTHERiPTHR24075:SF0 PTHR24075:SF0, 1 hit
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF02889 Sec63, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SM00973 Sec63, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF81296 SSF81296, 2 hits
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HGN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEYKYDEQ GIFFPVFLLV GTSCCVLPLT YSTILGPSAS KEKKNVRDPF
60 70 80 90 100
QKYRPKDLKV QRKSIFRLRY IFLILGWLAI GFLSYKIANS RLKLNIWDPY
110 120 130 140 150
EILGIAKGTS VDDVRRHYKR LSIKFHPDKV RNMVNTTREE VEKHYIEITN
160 170 180 190 200
AYRALTDDKT RENYALYGTP DVPQHISVGI ALPKWISESE NSIYILGFYG
210 220 230 240 250
LVFGIVLPYA VGKWWYGSRT YTRDHVHVDT VDEWFPKMET SLTLDELLSL
260 270 280 290 300
FASSKELTSL VPNEKNPKEY ILKLLFDHLN RKKTNNFNTH QILSQSDVVL
310 320 330 340 350
NALLSVATAF GFANPVDNVL KLWQHIVQAI PLDAPFPLLQ LPHLLMEDVK
360 370 380 390 400
NLSIRNISSI PQFLSLSEEQ TKDYLPNYSK NQLKEMREIA NGIPRISVVA
410 420 430 440 450
AKVLVDDDEY ITVGAIANLI LDLKCSYGTE VVPEVSTDGT ETATKKDEED
460 470 480 490 500
AEKYHQSKDV VLGDVETLPY AWAPYFTQHH KTAWWIYVVD PRQNRVIVPP
510 520 530 540 550
FSITDIPKTL RTFRIPFQVP PVAGTFSFQL HIMSNSYVGE DVISNLTMIV
560 570 580 590 600
KDTSVLQEQL QEEAVSDLED NSDIDESANA GKDFSDDENI GSDEEDESEY
610
DPMDTDTSDG E
Length:611
Mass (Da):69,726
Last modified:March 1, 2001 - v1
Checksum:iDA4BC288F13514D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAC05724.1
RefSeqiNP_595985.1, NM_001021892.2

Genome annotation databases

EnsemblFungiiSPBC36B7.03.1; SPBC36B7.03.1:pep; SPBC36B7.03
GeneIDi2540961
KEGGispo:SPBC36B7.03

Similar proteinsi

Entry informationi

Entry nameiSEC63_SCHPO
AccessioniPrimary (citable) accession number: Q9HGN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health