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Protein

Mitochondrial respiratory chain complexes assembly protein rca1

Gene

yta12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Acts as a component of the m-AAA protease complex which is a ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins. The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes. Function both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides (By similarity).By similarity

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi561 – 5611Zinc; catalyticBy similarity
Active sitei562 – 5621By similarity
Metal bindingi565 – 5651Zinc; catalyticBy similarity
Metal bindingi638 – 6381Zinc; catalyticBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi336 – 3438ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPSiM41.A14.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial respiratory chain complexes assembly protein rca1 (EC:3.4.24.-)
Gene namesi
Name:yta12
ORF Names:SPBC543.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC543.09.
PomBaseiSPBC543.09. yta12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei126 – 14621HelicalSequence analysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • m-AAA complex Source: PomBase
  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 773773Mitochondrial respiratory chain complexes assembly protein rca1PRO_0000317334Add
BLAST

Proteomic databases

MaxQBiQ9HGM3.

PTM databases

SwissPalmiQ9HGM3.

Interactioni

Protein-protein interaction databases

BioGridi277594. 1 interaction.
MINTiMINT-4703238.

Structurei

3D structure databases

ProteinModelPortaliQ9HGM3.
SMRiQ9HGM3. Positions 288-543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the AAA ATPase family.Curated
In the C-terminal section; belongs to the peptidase M41 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000217277.
InParanoidiQ9HGM3.
KOiK08956.
OMAiFPTENTD.
OrthoDBiEOG73V6TS.
PhylomeDBiQ9HGM3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HGM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNPFLTFRA PTRKTGDYLV SKFVKKDNFS SLRLARAYTF STRSTAVSQF
60 70 80 90 100
SLLSLSQRSF QSLKINKGIP EKHKIPLISS KQFSVTSKRS QNGSSGSNSD
110 120 130 140 150
ANGRKNGQKN DDSKKKGLNG NDPKKVFEIA LNGNTILGGI LVAYILYNVL
160 170 180 190 200
SPNANMQEIT WQDFRQQFLD KGLVERLVVV NRNMVRVILR GGVASGSGQY
210 220 230 240 250
YFSIGSIDSF DRKLEDAQRQ LGIPPSEFVP VAYHDEVSVL ATLLSFAPTL
260 270 280 290 300
LIIGSVIYLS RRASGAAGGG QGGIFGIGKS RAKMFNHETD IKIKFADVAG
310 320 330 340 350
VDEAKEEIME FVKFLKNPKF YERLGAKIPR GAILSGPPGT GKTLLAKATA
360 370 380 390 400
GEANVPFLSV SGSEFLEMFV GVGPSRVRDL FATARKNAPC IIFIDEIDAI
410 420 430 440 450
GKARGRGGQF GSNDERESTL NQLLVEMDGF TSSEHIVVFA GTNRPDVLDP
460 470 480 490 500
ALLRPGRFDR QITIDRPDIG GREQIFKVHL KHIKAADNID LIAKRLAVLT
510 520 530 540 550
SGFTGADIMN VCNEGALIAA RSNSNEVQMV HFEQAIERVT AGLEKKSRVL
560 570 580 590 600
SPEEKNTVAH HEAGHAVAGW FMEYVDPLLK VSIIPRAQAL GYASYLPKDQ
610 620 630 640 650
YLMSRGQILD QMGMALAGRV SEEIFFGPEK ITSGASDDFQ KVTRMAQAYV
660 670 680 690 700
TQYGMSPTVG TIAYPIDTRE TVQKPFSEAT AQMIDEEIRK LVKHAYERTK
710 720 730 740 750
KLLLEHKQGL ENIAQRLLQK EVITYNEVET ILGPRPYAYK HLNISELMRQ
760 770
SEYKNDHDPR NPPIPPSPQQ PSA
Length:773
Mass (Da):85,369
Last modified:March 1, 2001 - v1
Checksum:iE9263B76EAB9BEB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAC05251.1.
RefSeqiNP_596797.1. NM_001023817.2.

Genome annotation databases

EnsemblFungiiSPBC543.09.1; SPBC543.09.1:pep; SPBC543.09.
GeneIDi2541079.
KEGGispo:SPBC543.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAC05251.1.
RefSeqiNP_596797.1. NM_001023817.2.

3D structure databases

ProteinModelPortaliQ9HGM3.
SMRiQ9HGM3. Positions 288-543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277594. 1 interaction.
MINTiMINT-4703238.

Protein family/group databases

MEROPSiM41.A14.

PTM databases

SwissPalmiQ9HGM3.

Proteomic databases

MaxQBiQ9HGM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC543.09.1; SPBC543.09.1:pep; SPBC543.09.
GeneIDi2541079.
KEGGispo:SPBC543.09.

Organism-specific databases

EuPathDBiFungiDB:SPBC543.09.
PomBaseiSPBC543.09. yta12.

Phylogenomic databases

HOGENOMiHOG000217277.
InParanoidiQ9HGM3.
KOiK08956.
OMAiFPTENTD.
OrthoDBiEOG73V6TS.
PhylomeDBiQ9HGM3.

Miscellaneous databases

NextBioi20802192.
PROiQ9HGM3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYTA12_SCHPO
AccessioniPrimary (citable) accession number: Q9HGM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.