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Q9HG11

- MPKC_EMENI

UniProt

Q9HG11 - MPKC_EMENI

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Protein
Mitogen-activated protein kinase mpkC
Gene
mpkC, AN4668
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium By similarity.

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATP By similarity
Active sitei141 – 1411Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 349ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: ASPGD
Complete GO annotation...

GO - Biological processi

  1. MAPK cascade Source: GOC
  2. ascospore formation Source: ASPGD
  3. cellular response to osmotic stress Source: ASPGD
  4. establishment of cell polarity Source: ASPGD
  5. establishment or maintenance of cell polarity Source: ASPGD
  6. hyperosmotic response Source: ASPGD
  7. osmosensory signaling pathway Source: ASPGD
  8. penicillin biosynthetic process Source: ASPGD
  9. positive regulation of ascospore formation Source: ASPGD
  10. positive regulation of penicillin metabolic process Source: ASPGD
  11. positive regulation of sterigmatocystin biosynthetic process Source: ASPGD
  12. protein phosphorylation Source: ASPGD
  13. regulation of ascospore formation Source: ASPGD
  14. regulation of cleistothecium development Source: ASPGD
  15. regulation of conidiophore development Source: ASPGD
  16. regulation of secondary metabolite biosynthetic process Source: ASPGD
  17. sexual sporulation Source: ASPGD
  18. spore germination Source: ASPGD
  19. sporocarp development involved in sexual reproduction Source: ASPGD
  20. sterigmatocystin biosynthetic process Source: ASPGD
  21. tube fusion Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase mpkC (EC:2.7.11.24)
Short name:
MAP kinase C
Gene namesi
Name:mpkC
ORF Names:AN4668
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome III

Subcellular locationi

GO - Cellular componenti

  1. hyphal tip Source: ASPGD
  2. nuclear envelope Source: ASPGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Mitogen-activated protein kinase mpkC
PRO_0000289717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei171 – 1711Phosphothreonine By similarity
Modified residuei173 – 1731Phosphotyrosine By similarity

Post-translational modificationi

Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00005765.

Structurei

3D structure databases

ProteinModelPortaliQ9HG11.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 299280Protein kinase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi171 – 1733TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
KOiK04441.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HG11-1 [UniParc]FASTAAdd to Basket

« Hide

MAEFIRSDIL GTTFETTSRY ANLQPVGLGT AGVVCSAYDL ISEQVVAIKK    50
MMKPFHSTSV AKRTYREVKL LRHLRHDNLI NMSDIFISPL EDVYLVTELL 100
GTDLHRLLNG KPLESKFAQY FTYQILRGLK YIHSAGVIHR DLKPGNLLIN 150
ENCDLKICDF GLARVQEPQM TGYVSTRYYR APEIMLTWQR YGSKVDLWSV 200
GCILAEMLLG RPLFPGTDHI NQFWLITDLL GNPPDEVIDR ITTNNTRRVV 250
KSMAKRNPRP LKEILPAAED AALNLLDNLL VFDPDRRISA EQGLMHPWMA 300
PYHDPTDEPV ATEQFDWSFN DADLPLDTWK IMIYSEVLDF FQLTTNAEPS 350
GEQSQNQSQS QSQAFTSSQD LQLASMLNLG EGELLPDFAA TIDPNKFGSV 400
DYLMDGQSLD PNSFS 415
Length:415
Mass (Da):46,990
Last modified:January 9, 2007 - v2
Checksum:i9EB7A07F88F66FF8
GO

Sequence cautioni

The sequence CBF77037.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAA60710.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF195773 Genomic DNA. Translation: AAG28463.2.
EF137429 mRNA. Translation: ABL85065.1.
DQ402476 mRNA. Translation: ABD64614.1.
AACD01000080 Genomic DNA. Translation: EAA60710.1. Sequence problems.
BN001303 Genomic DNA. Translation: CBF77037.1. Sequence problems.
RefSeqiXP_662272.1. XM_657180.1.

Genome annotation databases

EnsemblFungiiCADANIAT00005765; CADANIAP00005765; CADANIAG00005765.
GeneIDi2872468.
KEGGiani:AN4668.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF195773 Genomic DNA. Translation: AAG28463.2 .
EF137429 mRNA. Translation: ABL85065.1 .
DQ402476 mRNA. Translation: ABD64614.1 .
AACD01000080 Genomic DNA. Translation: EAA60710.1 . Sequence problems.
BN001303 Genomic DNA. Translation: CBF77037.1 . Sequence problems.
RefSeqi XP_662272.1. XM_657180.1.

3D structure databases

ProteinModelPortali Q9HG11.
ModBasei Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00005765.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00005765 ; CADANIAP00005765 ; CADANIAG00005765 .
GeneIDi 2872468.
KEGGi ani:AN4668.2.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
KOi K04441.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a gene encoding a MAPK homolog from Aspergillus nidulans."
    Jahng K.-Y., Lee S.-J., Park H.-J., Chae K.-S., Han D.M.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "Isolation of a gene encoding a MAPK homolog from Aspergillus nidulans."
    Im Y.-E., Lee S.-J., Jahng K.-Y.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Novel mitogen-activated protein kinase MpkC of Aspergillus fumigatus is required for utilization of polyalcohol sugars."
    Reyes G., Romans A., Nguyen C.K., May G.S.
    Eukaryot. Cell 5:1934-1940(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  5. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiMPKC_EMENI
AccessioniPrimary (citable) accession number: Q9HG11
Secondary accession number(s): C8VB11, Q208R0, Q5B462
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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