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Protein

Mitogen-activated protein kinase mpkC

Gene

mpkC

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei49ATPPROSITE-ProRule annotation1
Active sitei141Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 34ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase mpkC (EC:2.7.11.24)
Short name:
MAP kinase C
Gene namesi
Name:mpkC
ORF Names:AN4668
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome III
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002897171 – 415Mitogen-activated protein kinase mpkCAdd BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171PhosphothreonineBy similarity1
Modified residuei173PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ9HG11
SMRiQ9HG11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 299Protein kinasePROSITE-ProRule annotationAdd BLAST280

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi171 – 173TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233024
InParanoidiQ9HG11
KOiK04441
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR038783 MAPK_Sty1/Hog1
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24055:SF247 PTHR24055:SF247, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HG11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFIRSDIL GTTFETTSRY ANLQPVGLGT AGVVCSAYDL ISEQVVAIKK
60 70 80 90 100
MMKPFHSTSV AKRTYREVKL LRHLRHDNLI NMSDIFISPL EDVYLVTELL
110 120 130 140 150
GTDLHRLLNG KPLESKFAQY FTYQILRGLK YIHSAGVIHR DLKPGNLLIN
160 170 180 190 200
ENCDLKICDF GLARVQEPQM TGYVSTRYYR APEIMLTWQR YGSKVDLWSV
210 220 230 240 250
GCILAEMLLG RPLFPGTDHI NQFWLITDLL GNPPDEVIDR ITTNNTRRVV
260 270 280 290 300
KSMAKRNPRP LKEILPAAED AALNLLDNLL VFDPDRRISA EQGLMHPWMA
310 320 330 340 350
PYHDPTDEPV ATEQFDWSFN DADLPLDTWK IMIYSEVLDF FQLTTNAEPS
360 370 380 390 400
GEQSQNQSQS QSQAFTSSQD LQLASMLNLG EGELLPDFAA TIDPNKFGSV
410
DYLMDGQSLD PNSFS
Length:415
Mass (Da):46,990
Last modified:January 9, 2007 - v2
Checksum:i9EB7A07F88F66FF8
GO

Sequence cautioni

The sequence CBF77037 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAA60710 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195773 Genomic DNA Translation: AAG28463.2
EF137429 mRNA Translation: ABL85065.1
DQ402476 mRNA Translation: ABD64614.1
AACD01000080 Genomic DNA Translation: EAA60710.1 Sequence problems.
BN001303 Genomic DNA Translation: CBF77037.1 Sequence problems.
RefSeqiXP_662272.1, XM_657180.1

Genome annotation databases

EnsemblFungiiCADANIAT00005765; CADANIAP00005765; CADANIAG00005765
EAA60710; EAA60710; AN4668.2
GeneIDi2872468
KEGGiani:AN4668.2

Similar proteinsi

Entry informationi

Entry nameiMPKC_EMENI
AccessioniPrimary (citable) accession number: Q9HG11
Secondary accession number(s): C8VB11, Q208R0, Q5B462
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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