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Q9HG11

- MPKC_EMENI

UniProt

Q9HG11 - MPKC_EMENI

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Protein

Mitogen-activated protein kinase mpkC

Gene

mpkC

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATPPROSITE-ProRule annotation
Active sitei141 – 1411Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: ASPGD

GO - Biological processi

  1. ascospore formation Source: ASPGD
  2. cellular response to osmotic stress Source: ASPGD
  3. establishment of cell polarity Source: ASPGD
  4. establishment or maintenance of cell polarity Source: ASPGD
  5. hyperosmotic response Source: ASPGD
  6. MAPK cascade Source: GOC
  7. osmosensory signaling pathway Source: ASPGD
  8. penicillin biosynthetic process Source: ASPGD
  9. positive regulation of ascospore formation Source: ASPGD
  10. positive regulation of penicillin metabolic process Source: ASPGD
  11. positive regulation of sterigmatocystin biosynthetic process Source: ASPGD
  12. protein phosphorylation Source: ASPGD
  13. regulation of ascospore formation Source: ASPGD
  14. regulation of cleistothecium development Source: ASPGD
  15. regulation of conidiophore development Source: ASPGD
  16. regulation of secondary metabolite biosynthetic process Source: ASPGD
  17. sexual sporulation Source: ASPGD
  18. spore germination Source: ASPGD
  19. sporocarp development involved in sexual reproduction Source: ASPGD
  20. sterigmatocystin biosynthetic process Source: ASPGD
  21. tube fusion Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase mpkC (EC:2.7.11.24)
Short name:
MAP kinase C
Gene namesi
Name:mpkC
ORF Names:AN4668
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome III

Subcellular locationi

GO - Cellular componenti

  1. hyphal tip Source: ASPGD
  2. nuclear envelope Source: ASPGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Mitogen-activated protein kinase mpkCPRO_0000289717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei171 – 1711PhosphothreonineBy similarity
Modified residuei173 – 1731PhosphotyrosineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00005765.

Structurei

3D structure databases

ProteinModelPortaliQ9HG11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 299280Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi171 – 1733TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ9HG11.
KOiK04441.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HG11-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEFIRSDIL GTTFETTSRY ANLQPVGLGT AGVVCSAYDL ISEQVVAIKK
60 70 80 90 100
MMKPFHSTSV AKRTYREVKL LRHLRHDNLI NMSDIFISPL EDVYLVTELL
110 120 130 140 150
GTDLHRLLNG KPLESKFAQY FTYQILRGLK YIHSAGVIHR DLKPGNLLIN
160 170 180 190 200
ENCDLKICDF GLARVQEPQM TGYVSTRYYR APEIMLTWQR YGSKVDLWSV
210 220 230 240 250
GCILAEMLLG RPLFPGTDHI NQFWLITDLL GNPPDEVIDR ITTNNTRRVV
260 270 280 290 300
KSMAKRNPRP LKEILPAAED AALNLLDNLL VFDPDRRISA EQGLMHPWMA
310 320 330 340 350
PYHDPTDEPV ATEQFDWSFN DADLPLDTWK IMIYSEVLDF FQLTTNAEPS
360 370 380 390 400
GEQSQNQSQS QSQAFTSSQD LQLASMLNLG EGELLPDFAA TIDPNKFGSV
410
DYLMDGQSLD PNSFS
Length:415
Mass (Da):46,990
Last modified:January 9, 2007 - v2
Checksum:i9EB7A07F88F66FF8
GO

Sequence cautioni

The sequence CBF77037.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence EAA60710.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195773 Genomic DNA. Translation: AAG28463.2.
EF137429 mRNA. Translation: ABL85065.1.
DQ402476 mRNA. Translation: ABD64614.1.
AACD01000080 Genomic DNA. Translation: EAA60710.1. Sequence problems.
BN001303 Genomic DNA. Translation: CBF77037.1. Sequence problems.
RefSeqiXP_662272.1. XM_657180.1.

Genome annotation databases

EnsemblFungiiCADANIAT00005765; CADANIAP00005765; CADANIAG00005765.
GeneIDi2872468.
KEGGiani:AN4668.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195773 Genomic DNA. Translation: AAG28463.2 .
EF137429 mRNA. Translation: ABL85065.1 .
DQ402476 mRNA. Translation: ABD64614.1 .
AACD01000080 Genomic DNA. Translation: EAA60710.1 . Sequence problems.
BN001303 Genomic DNA. Translation: CBF77037.1 . Sequence problems.
RefSeqi XP_662272.1. XM_657180.1.

3D structure databases

ProteinModelPortali Q9HG11.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00005765.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00005765 ; CADANIAP00005765 ; CADANIAG00005765 .
GeneIDi 2872468.
KEGGi ani:AN4668.2.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
InParanoidi Q9HG11.
KOi K04441.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a gene encoding a MAPK homolog from Aspergillus nidulans."
    Jahng K.-Y., Lee S.-J., Park H.-J., Chae K.-S., Han D.M.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "Isolation of a gene encoding a MAPK homolog from Aspergillus nidulans."
    Im Y.-E., Lee S.-J., Jahng K.-Y.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Novel mitogen-activated protein kinase MpkC of Aspergillus fumigatus is required for utilization of polyalcohol sugars."
    Reyes G., Romans A., Nguyen C.K., May G.S.
    Eukaryot. Cell 5:1934-1940(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  5. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiMPKC_EMENI
AccessioniPrimary (citable) accession number: Q9HG11
Secondary accession number(s): C8VB11, Q208R0, Q5B462
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 9, 2007
Last modified: November 26, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3