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Q9HG11

- MPKC_EMENI

UniProt

Q9HG11 - MPKC_EMENI

Protein

Mitogen-activated protein kinase mpkC

Gene

mpkC

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by tyrosine and threonine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei49 – 491ATPPROSITE-ProRule annotation
    Active sitei141 – 1411Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: ASPGD

    GO - Biological processi

    1. ascospore formation Source: ASPGD
    2. cellular response to osmotic stress Source: ASPGD
    3. establishment of cell polarity Source: ASPGD
    4. establishment or maintenance of cell polarity Source: ASPGD
    5. hyperosmotic response Source: ASPGD
    6. MAPK cascade Source: GOC
    7. osmosensory signaling pathway Source: ASPGD
    8. penicillin biosynthetic process Source: ASPGD
    9. positive regulation of ascospore formation Source: ASPGD
    10. positive regulation of penicillin metabolic process Source: ASPGD
    11. positive regulation of sterigmatocystin biosynthetic process Source: ASPGD
    12. protein phosphorylation Source: ASPGD
    13. regulation of ascospore formation Source: ASPGD
    14. regulation of cleistothecium development Source: ASPGD
    15. regulation of conidiophore development Source: ASPGD
    16. regulation of secondary metabolite biosynthetic process Source: ASPGD
    17. sexual sporulation Source: ASPGD
    18. spore germination Source: ASPGD
    19. sporocarp development involved in sexual reproduction Source: ASPGD
    20. sterigmatocystin biosynthetic process Source: ASPGD
    21. tube fusion Source: ASPGD

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase mpkC (EC:2.7.11.24)
    Short name:
    MAP kinase C
    Gene namesi
    Name:mpkC
    ORF Names:AN4668
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome III

    Subcellular locationi

    GO - Cellular componenti

    1. hyphal tip Source: ASPGD
    2. nuclear envelope Source: ASPGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415Mitogen-activated protein kinase mpkCPRO_0000289717Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei171 – 1711PhosphothreonineBy similarity
    Modified residuei173 – 1731PhosphotyrosineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi162425.CADANIAP00005765.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HG11.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 299280Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi171 – 1733TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    KOiK04441.
    OrthoDBiEOG7K3TWD.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HG11-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEFIRSDIL GTTFETTSRY ANLQPVGLGT AGVVCSAYDL ISEQVVAIKK    50
    MMKPFHSTSV AKRTYREVKL LRHLRHDNLI NMSDIFISPL EDVYLVTELL 100
    GTDLHRLLNG KPLESKFAQY FTYQILRGLK YIHSAGVIHR DLKPGNLLIN 150
    ENCDLKICDF GLARVQEPQM TGYVSTRYYR APEIMLTWQR YGSKVDLWSV 200
    GCILAEMLLG RPLFPGTDHI NQFWLITDLL GNPPDEVIDR ITTNNTRRVV 250
    KSMAKRNPRP LKEILPAAED AALNLLDNLL VFDPDRRISA EQGLMHPWMA 300
    PYHDPTDEPV ATEQFDWSFN DADLPLDTWK IMIYSEVLDF FQLTTNAEPS 350
    GEQSQNQSQS QSQAFTSSQD LQLASMLNLG EGELLPDFAA TIDPNKFGSV 400
    DYLMDGQSLD PNSFS 415
    Length:415
    Mass (Da):46,990
    Last modified:January 9, 2007 - v2
    Checksum:i9EB7A07F88F66FF8
    GO

    Sequence cautioni

    The sequence CBF77037.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence EAA60710.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF195773 Genomic DNA. Translation: AAG28463.2.
    EF137429 mRNA. Translation: ABL85065.1.
    DQ402476 mRNA. Translation: ABD64614.1.
    AACD01000080 Genomic DNA. Translation: EAA60710.1. Sequence problems.
    BN001303 Genomic DNA. Translation: CBF77037.1. Sequence problems.
    RefSeqiXP_662272.1. XM_657180.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00005765; CADANIAP00005765; CADANIAG00005765.
    GeneIDi2872468.
    KEGGiani:AN4668.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF195773 Genomic DNA. Translation: AAG28463.2 .
    EF137429 mRNA. Translation: ABL85065.1 .
    DQ402476 mRNA. Translation: ABD64614.1 .
    AACD01000080 Genomic DNA. Translation: EAA60710.1 . Sequence problems.
    BN001303 Genomic DNA. Translation: CBF77037.1 . Sequence problems.
    RefSeqi XP_662272.1. XM_657180.1.

    3D structure databases

    ProteinModelPortali Q9HG11.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 162425.CADANIAP00005765.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00005765 ; CADANIAP00005765 ; CADANIAG00005765 .
    GeneIDi 2872468.
    KEGGi ani:AN4668.2.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    KOi K04441.
    OrthoDBi EOG7K3TWD.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a gene encoding a MAPK homolog from Aspergillus nidulans."
      Jahng K.-Y., Lee S.-J., Park H.-J., Chae K.-S., Han D.M.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. "Isolation of a gene encoding a MAPK homolog from Aspergillus nidulans."
      Im Y.-E., Lee S.-J., Jahng K.-Y.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Novel mitogen-activated protein kinase MpkC of Aspergillus fumigatus is required for utilization of polyalcohol sugars."
      Reyes G., Romans A., Nguyen C.K., May G.S.
      Eukaryot. Cell 5:1934-1940(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    5. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiMPKC_EMENI
    AccessioniPrimary (citable) accession number: Q9HG11
    Secondary accession number(s): C8VB11, Q208R0, Q5B462
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3