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Protein

78 kDa glucose-regulated protein homolog

Gene

BiP

Organism
Pichia angusta (Yeast) (Hansenula polymorpha)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. response to unfolded protein Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name:
BiP
Gene namesi
Name:BiP
OrganismiPichia angusta (Yeast) (Hansenula polymorpha)
Taxonomic identifieri870730 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPichiaceaeOgataea

Subcellular locationi

  1. Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 66563278 kDa glucose-regulated protein homologPRO_0000013584Add
BLAST

Proteomic databases

PRIDEiQ9HG01.

Structurei

3D structure databases

ProteinModelPortaliQ9HG01.
SMRiQ9HG01. Positions 40-579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi662 – 6654Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

PhylomeDBiQ9HG01.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HG01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTFNKSVVS CAAIIYALLL VVLPLTTQQF VKAESNENYG TVIGIDLGTT
60 70 80 90 100
YSCVGVMKAG RVEIIPNDQG NRITPSYVAF TEDERLVGDA AKNQIASNPT
110 120 130 140 150
NTIFDIKRLI GHRFDDKVIQ KEIKHLPYKV KDQDGRPVVE AKVNGELKTF
160 170 180 190 200
TAEEISAMIL GKMKQIAEDY LGKKVTHAVV TVPAYFNDAQ RQATKDAGTI
210 220 230 240 250
AGLEVLRIVN EPTAAAIAYG LDKTDEEKHI IVYDLGGGTF DVSLLTIAGG
260 270 280 290 300
AFEVLATAGD THLGGEDFDY RVVRHFIKVF KKKHGIDISD NSKALAKLKR
310 320 330 340 350
EVEKAKRTLS SQMSTRIEID SFVDGIDFSE SLSRAKFEEL NMDLFKKTLK
360 370 380 390 400
PVQQVLDDAK MKPDEIDDVV FVGGSTRIPK VQELIENFFN GKKISKGINP
410 420 430 440 450
DEAVAFGAAV QGGVLSGEEG VEDIVLIDVN PLTLGIETSG GVMTTLIKRN
460 470 480 490 500
TPIPTQKSQI FSTAADNQPV VLIQVYEGER AMAKDNNLLG KFELTGIPPA
510 520 530 540 550
PRGVPQIEVT FTLDSNGILK VSATDKGTGK SNSITITNDK GRLSKEEIEK
560 570 580 590 600
KIEEAEKFAQ QDKELREKVE SRNALENYAH SLKNQANDEN GFGAKLEEDD
610 620 630 640 650
KETLLDAINE ALEFLEDNFD TATKDEFDEQ KEKLSKVAYP ITSKLYDAPP
660
TSDEEDEDDW DHDEL
Length:665
Mass (Da):73,222
Last modified:March 1, 2001 - v1
Checksum:i9A23F7BCCC0364B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245405 Genomic DNA. Translation: AAG09776.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245405 Genomic DNA. Translation: AAG09776.1.

3D structure databases

ProteinModelPortaliQ9HG01.
SMRiQ9HG01. Positions 40-579.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9HG01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

PhylomeDBiQ9HG01.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Overproduction of BiP negatively affects the secretion of Aspergillus niger glucose oxidase by the yeast Hansenula polymorpha."
    van der Heide M., Hollenberg C.P., van der Klei I.J., Veenhuis M.
    Appl. Microbiol. Biotechnol. 58:487-494(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 14754 / CBS 1976 / JCM 3620 / NBRC 0799 / NCYC 495 / NRRL Y-1798 / VKM Y-1397.

Entry informationi

Entry nameiGRP78_PICAN
AccessioniPrimary (citable) accession number: Q9HG01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.