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Q9HG01

- GRP78_PICAN

UniProt

Q9HG01 - GRP78_PICAN

Protein

78 kDa glucose-regulated protein homolog

Gene

BiP

Organism
Pichia angusta (Yeast) (Hansenula polymorpha)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. response to unfolded protein Source: UniProtKB

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    78 kDa glucose-regulated protein homolog
    Short name:
    GRP-78
    Alternative name(s):
    Immunoglobulin heavy chain-binding protein homolog
    Short name:
    BiP
    Gene namesi
    Name:BiP
    OrganismiPichia angusta (Yeast) (Hansenula polymorpha)
    Taxonomic identifieri870730 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetales incertae sedisOgataea

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 66563278 kDa glucose-regulated protein homologPRO_0000013584Add
    BLAST

    Proteomic databases

    PRIDEiQ9HG01.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HG01.
    SMRiQ9HG01. Positions 40-579.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi662 – 6654Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    PhylomeDBiQ9HG01.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9HG01-1 [UniParc]FASTAAdd to Basket

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    MLTFNKSVVS CAAIIYALLL VVLPLTTQQF VKAESNENYG TVIGIDLGTT    50
    YSCVGVMKAG RVEIIPNDQG NRITPSYVAF TEDERLVGDA AKNQIASNPT 100
    NTIFDIKRLI GHRFDDKVIQ KEIKHLPYKV KDQDGRPVVE AKVNGELKTF 150
    TAEEISAMIL GKMKQIAEDY LGKKVTHAVV TVPAYFNDAQ RQATKDAGTI 200
    AGLEVLRIVN EPTAAAIAYG LDKTDEEKHI IVYDLGGGTF DVSLLTIAGG 250
    AFEVLATAGD THLGGEDFDY RVVRHFIKVF KKKHGIDISD NSKALAKLKR 300
    EVEKAKRTLS SQMSTRIEID SFVDGIDFSE SLSRAKFEEL NMDLFKKTLK 350
    PVQQVLDDAK MKPDEIDDVV FVGGSTRIPK VQELIENFFN GKKISKGINP 400
    DEAVAFGAAV QGGVLSGEEG VEDIVLIDVN PLTLGIETSG GVMTTLIKRN 450
    TPIPTQKSQI FSTAADNQPV VLIQVYEGER AMAKDNNLLG KFELTGIPPA 500
    PRGVPQIEVT FTLDSNGILK VSATDKGTGK SNSITITNDK GRLSKEEIEK 550
    KIEEAEKFAQ QDKELREKVE SRNALENYAH SLKNQANDEN GFGAKLEEDD 600
    KETLLDAINE ALEFLEDNFD TATKDEFDEQ KEKLSKVAYP ITSKLYDAPP 650
    TSDEEDEDDW DHDEL 665
    Length:665
    Mass (Da):73,222
    Last modified:March 1, 2001 - v1
    Checksum:i9A23F7BCCC0364B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF245405 Genomic DNA. Translation: AAG09776.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF245405 Genomic DNA. Translation: AAG09776.1 .

    3D structure databases

    ProteinModelPortali Q9HG01.
    SMRi Q9HG01. Positions 40-579.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9HG01.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    PhylomeDBi Q9HG01.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Overproduction of BiP negatively affects the secretion of Aspergillus niger glucose oxidase by the yeast Hansenula polymorpha."
      van der Heide M., Hollenberg C.P., van der Klei I.J., Veenhuis M.
      Appl. Microbiol. Biotechnol. 58:487-494(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 14754 / CBS 1976 / JCM 3620 / NBRC 0799 / NCYC 495 / NRRL Y-1798 / VKM Y-1397.

    Entry informationi

    Entry nameiGRP78_PICAN
    AccessioniPrimary (citable) accession number: Q9HG01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3