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Q9HG01

- GRP78_PICAN

UniProt

Q9HG01 - GRP78_PICAN

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Protein
78 kDa glucose-regulated protein homolog
Gene
BiP
Organism
Pichia angusta (Yeast) (Hansenula polymorpha)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. response to unfolded protein Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name:
BiP
Gene namesi
Name:BiP
OrganismiPichia angusta (Yeast) (Hansenula polymorpha)
Taxonomic identifieri870730 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetales incertae sedisOgataea

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed prediction
Add
BLAST
Chaini34 – 66563278 kDa glucose-regulated protein homolog
PRO_0000013584Add
BLAST

Proteomic databases

PRIDEiQ9HG01.

Structurei

3D structure databases

ProteinModelPortaliQ9HG01.
SMRiQ9HG01. Positions 40-579.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi662 – 6654Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

PhylomeDBiQ9HG01.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HG01-1 [UniParc]FASTAAdd to Basket

« Hide

MLTFNKSVVS CAAIIYALLL VVLPLTTQQF VKAESNENYG TVIGIDLGTT    50
YSCVGVMKAG RVEIIPNDQG NRITPSYVAF TEDERLVGDA AKNQIASNPT 100
NTIFDIKRLI GHRFDDKVIQ KEIKHLPYKV KDQDGRPVVE AKVNGELKTF 150
TAEEISAMIL GKMKQIAEDY LGKKVTHAVV TVPAYFNDAQ RQATKDAGTI 200
AGLEVLRIVN EPTAAAIAYG LDKTDEEKHI IVYDLGGGTF DVSLLTIAGG 250
AFEVLATAGD THLGGEDFDY RVVRHFIKVF KKKHGIDISD NSKALAKLKR 300
EVEKAKRTLS SQMSTRIEID SFVDGIDFSE SLSRAKFEEL NMDLFKKTLK 350
PVQQVLDDAK MKPDEIDDVV FVGGSTRIPK VQELIENFFN GKKISKGINP 400
DEAVAFGAAV QGGVLSGEEG VEDIVLIDVN PLTLGIETSG GVMTTLIKRN 450
TPIPTQKSQI FSTAADNQPV VLIQVYEGER AMAKDNNLLG KFELTGIPPA 500
PRGVPQIEVT FTLDSNGILK VSATDKGTGK SNSITITNDK GRLSKEEIEK 550
KIEEAEKFAQ QDKELREKVE SRNALENYAH SLKNQANDEN GFGAKLEEDD 600
KETLLDAINE ALEFLEDNFD TATKDEFDEQ KEKLSKVAYP ITSKLYDAPP 650
TSDEEDEDDW DHDEL 665
Length:665
Mass (Da):73,222
Last modified:March 1, 2001 - v1
Checksum:i9A23F7BCCC0364B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF245405 Genomic DNA. Translation: AAG09776.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF245405 Genomic DNA. Translation: AAG09776.1 .

3D structure databases

ProteinModelPortali Q9HG01.
SMRi Q9HG01. Positions 40-579.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9HG01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

PhylomeDBi Q9HG01.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Overproduction of BiP negatively affects the secretion of Aspergillus niger glucose oxidase by the yeast Hansenula polymorpha."
    van der Heide M., Hollenberg C.P., van der Klei I.J., Veenhuis M.
    Appl. Microbiol. Biotechnol. 58:487-494(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 14754 / CBS 1976 / JCM 3620 / NBRC 0799 / NCYC 495 / NRRL Y-1798 / VKM Y-1397.

Entry informationi

Entry nameiGRP78_PICAN
AccessioniPrimary (citable) accession number: Q9HG01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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