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Q9HFX0 (PYRF_ZYGBA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
OrganismZygosaccharomyces bailii
Taxonomic identifier4954 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Orotidine 5'-phosphate decarboxylase
PRO_0000134693

Regions

Region59 – 613Substrate binding By similarity
Region91 – 10010Substrate binding By similarity

Sites

Active site931Proton donor By similarity
Binding site371Substrate By similarity
Binding site2171Substrate By similarity
Binding site2351Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HFX0 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 32A5A0A024BB8BE0

FASTA26529,165
        10         20         30         40         50         60 
MSTATYHDRA AKHASPLASK LLELMHEKQT NLCASLDVDT TTELLRLVDI LGPYICLVKT 

        70         80         90        100        110        120 
HVDILSDFSM DGTVKPLKEL AAKHKFLIFE DRKFADIGNT VKLQYSSGVY QISQWADITN 

       130        140        150        160        170        180 
AHGVTGPGIV QGLKQAAEET TQEPRGLLML AELSSKGSLA HGEYTKGTVE IAKTDKDFVI 

       190        200        210        220        230        240 
GFIAQRDMGG RDEGYDWLIM TPGVGLEDKS DALGQQYRTV EDVISTGSDI IIVGRGLFGK 

       250        260 
GRDPKIEGDR YRKAGWEAYL KRCNP 

« Hide

References

[1]"Targeted gene deletion in Zygosaccharomyces bailii."
Mollapour M., Piper P.W.
Yeast 18:173-186(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CBS 685 / NCYC 563 / NRRL Y-12949.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF279259 Genomic DNA. Translation: AAG17694.1.

3D structure databases

ProteinModelPortalQ9HFX0.
SMRQ9HFX0. Positions 1-263.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_ZYGBA
AccessionPrimary (citable) accession number: Q9HFX0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways