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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

TRP1

Organism
Zygosaccharomyces bailii
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathway: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. N-(5'-phosphoribosyl)anthranilate isomerase (TRP1)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:TRP1
OrganismiZygosaccharomyces bailii
Taxonomic identifieri4954 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154338Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9HFW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.Curated

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HFW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAKICGLQS VEAAQQAVDN GADLIGVICV PNRKRTVDPE IARSISKICH
60 70 80 90 100
GTGTRLVGVF RNQPKEEVRQ LAQEYELDVV QLHGDEDWQE YASYVGLPLL
110 120 130 140 150
KRVVFPRDVS LVSQMDGEVC TPLFDSEAGG SGEKLDWQAI GSWFQDSQLT
160 170 180 190 200
RGYLLAGGLS PDNVVEALRV PGVVGVDVSG GVETDGTKDL AKIKQFLELY

KVNVN
Length:205
Mass (Da):22,316
Last modified:March 1, 2001 - v1
Checksum:iDECD9AE9F0DDBC0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279262 Genomic DNA. Translation: AAG17697.1.
AJ309279 Genomic DNA. Translation: CAC37331.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279262 Genomic DNA. Translation: AAG17697.1.
AJ309279 Genomic DNA. Translation: CAC37331.1.

3D structure databases

ProteinModelPortaliQ9HFW8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Targeted gene deletion in Zygosaccharomyces bailii."
    Mollapour M., Piper P.W.
    Yeast 18:173-186(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CBS 685 / NCYC 563 / NRRL Y-12949.
  2. "Sequence analyses of a Zygosaccharomyces bailii DNA fragment containing the Thr-tRNA, IPP1 and TRP1 genes."
    Rodrigues F.J., Steensma Y., Corte-Real M.S.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ISA 1307.

Entry informationi

Entry nameiTRPF_ZYGBA
AccessioniPrimary (citable) accession number: Q9HFW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2001
Last modified: April 1, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.