1,3,6,8-tetrahydroxynaphthalene reductase - Magnaporthe grisea (Crabgrass-specific blast fungus)

Preferred order of sections

Names and origin

Protein names	Submitted name: 1,3,6,8-tetrahydroxynaphthalene reductase EMBL AAW55622.1 Submitted name: Tetrahydroxynaphthalene reductase EMBL AAG29497.2
Organism	Magnaporthe grisea (Crabgrass-specific blast fungus) (Pyricularia grisea) EMBL AAG29497.2
Taxonomic identifier	148305 [NCBI]
Taxonomic lineage	Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Magnaporthales › Magnaporthaceae › Magnaporthe

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family. RuleBase RU000363

Ontologies

Keywords
Ligand	NADP PDB 1JA9 Nucleotide-binding PDB 1JA9
Molecular function	Oxidoreductase RuleBase RU004267
Technical term	3D-structure PDB 1JA9
Gene Ontology (GO)
Molecular function	nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Nucleotide binding

28 – 33

6

NADP PDB 1JA9

Nucleotide binding

53 – 55

3

NADP PDB 1JA9

Nucleotide binding

79 – 80

2

NADP PDB 1JA9

Nucleotide binding

106 – 107

2

NADP PDB 1JA9

Nucleotide binding

203 – 205

3

NADP PDB 1JA9

Sites

Binding site

170

1

NADP PDB 1JA9

Binding site

174

1

NADP PDB 1JA9

Sequences

Sequence

Length

Mass (Da)

Tools

Q9HFV6 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: 3A6EFD36139DEC3B
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FASTA

274

28,638

        10         20         30         40         50         60 
MAPSADITSS GPSDASKPLA GKVALVTGAG RGIGRGIAIE LGRRGASVVV NYGSSSKAAE 

        70         80         90        100        110        120 
EVVAELKKLG AQGVAIQADI SKPSEVVALF DKAVSHFGGL DFVMSNSGME VWCDELEVTQ 

       130        140        150        160        170        180 
ELFDKVFNLN TRGQFFVAQQ GLKHCRRGGR IILTSSIAAV MTGIPNHALY AGSKAAVEGF 

       190        200        210        220        230        240 
CRAFAVDCGA KGVTVNCIAP GGVKTDMFDE NSWHYAPGGY KGMPQEKIDE GLANMNPLKR 

       250        260        270 
IGYPADIGRA VSALCQEESE WINGQVIKLT GGGI

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References

[1]	"The second naphthol reductase of fungal melanin biosynthesis in Magnaporthe grisea: tetrahydroxynaphthalene reductase." Thompson J.E., Fahnestock S., Farrall L., Liao D.I., Valent B., Jordan D.B. J. Biol. Chem. 275:34867-34872(2000) [PubMed: 10956664] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"A structural account of substrate and inhibitor specificity differences between two naphthol reductases." Liao D.I., Thompson J.E., Fahnestock S., Valent B., Jordan D.B. Biochemistry 40:8696-8704(2001) [PubMed: 11467929] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH NADP.
[3]	"Isolation, Characterization and Preliminary Genetic Analysis of Laboratory Tricyclazole-resistant Mutants of the Rice Blast Fungus, Magnaporthe grisea." Zhang C.-Q., Zhu G.N., Ma Z.H., Zhou M.-G. J. Phytopathol. 154:392-397(2006) [Agricola: IND43821857] Cited for: NUCLEOTIDE SEQUENCE.
[4]	Fahnestock S., Valent B., Farrall L., Sweigard J.A., Chumley F.G. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF290182 mRNA. Translation: AAG29497.2.
AY846877 Genomic DNA. Translation: AAW55622.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JA9	X-ray	1.50	A	1-274	[»]

ProteinModelPortal

Q9HFV6.

SMR

Q9HFV6. Positions 16-274.

ModBase

Search...

Protein-protein interaction databases

STRING

Q9HFV6.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

NMPDR

fig|242507.1.peg.9030.

Phylogenomic databases

OrthoDB

EOG4HX88X.

PhylomeDB

Q9HFV6.

Family and domain databases

InterPro

IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]

Gene3D

G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.

Pfam

PF00106. adh_short. 1 hit.
[Graphical view]

PRINTS

PR00081. GDHRDH.
PR00080. SDRFAMILY.

PROSITE

PS00061. ADH_SHORT. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q9HFV6_MAGGR

Accession

Primary (citable) accession number: Q9HFV6

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	June 1, 2001
Last modified:	December 14, 2011
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)