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Q9HFV5 (HIS4_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

EC=5.3.1.16
Alternative name(s):
5-proFAR isomerase
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene names
Name:HIS6
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the HisA/HisF family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   Molecular functionIsomerase
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2792791-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
PRO_0000141956

Sequences

Sequence LengthMass (Da)Tools
Q9HFV5 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 259D1E50F41C4624

FASTA27930,796
        10         20         30         40         50         60 
MTKFRGCIDI HSGQVKQIVG GTLTQDDSAS SKTSSAKENF VSTKPSSHYA QLYKDYNVKG 

        70         80         90        100        110        120 
CHVIKLGSNP ANDDAAKLAL STWPHNLQVG GGINLDNAQY WLDQGASHVI LTSWLFTKNE 

       130        140        150        160        170        180 
QDKMELDFGK LREISKLIGK EKLIVDLSCR TVIENGKTNW YVAMNKWQTI TDTILSAEFL 

       190        200        210        220        230        240 
LKVSAYCDEF LIHAADVEGL CKGIDEKLVE NLGEWCPVGF EEKIVYAGGA KSINDLDTVA 

       250        260        270 
KLSKGKVDLT YGSSLDIFSG KLVNFTDLVE WNKANSKTN 

« Hide

References

[1]"Cloning and characterization of the CaHIS6 and CaHIS7 genes from the fungal pathogen Candida albicans."
Day T.W., Davisson V.J.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF290199 Genomic DNA. Translation: AAG17873.1.

3D structure databases

ProteinModelPortalQ9HFV5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0106.

Enzyme and pathway databases

UniPathwayUPA00031; UER00009.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR011858. HisA_euk.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERPTHR21169. PTHR21169. 1 hit.
PfamPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02129. hisA_euk. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHIS4_CANAX
AccessionPrimary (citable) accession number: Q9HFV5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: March 1, 2001
Last modified: October 16, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways