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Q9HFV5

- HIS4_CANAX

UniProt

Q9HFV5 - HIS4_CANAX

Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene

HIS6

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.

    Pathwayi

    GO - Molecular functioni

    1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
    Alternative name(s):
    5-proFAR isomerase
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
    Gene namesi
    Name:HIS6
    OrganismiCandida albicans (Yeast)
    Taxonomic identifieri5476 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2792791-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerasePRO_0000141956Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HFV5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HisA/HisF family.Curated

    Phylogenomic databases

    eggNOGiCOG0106.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR011858. HisA_euk.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PANTHERiPTHR21169. PTHR21169. 1 hit.
    PfamiPF00977. His_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR02129. hisA_euk. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9HFV5-1 [UniParc]FASTAAdd to Basket

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    MTKFRGCIDI HSGQVKQIVG GTLTQDDSAS SKTSSAKENF VSTKPSSHYA    50
    QLYKDYNVKG CHVIKLGSNP ANDDAAKLAL STWPHNLQVG GGINLDNAQY 100
    WLDQGASHVI LTSWLFTKNE QDKMELDFGK LREISKLIGK EKLIVDLSCR 150
    TVIENGKTNW YVAMNKWQTI TDTILSAEFL LKVSAYCDEF LIHAADVEGL 200
    CKGIDEKLVE NLGEWCPVGF EEKIVYAGGA KSINDLDTVA KLSKGKVDLT 250
    YGSSLDIFSG KLVNFTDLVE WNKANSKTN 279
    Length:279
    Mass (Da):30,796
    Last modified:March 1, 2001 - v1
    Checksum:i259D1E50F41C4624
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF290199 Genomic DNA. Translation: AAG17873.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF290199 Genomic DNA. Translation: AAG17873.1 .

    3D structure databases

    ProteinModelPortali Q9HFV5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0106.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00009 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR011858. HisA_euk.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    PANTHERi PTHR21169. PTHR21169. 1 hit.
    Pfami PF00977. His_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR02129. hisA_euk. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the CaHIS6 and CaHIS7 genes from the fungal pathogen Candida albicans."
      Day T.W., Davisson V.J.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiHIS4_CANAX
    AccessioniPrimary (citable) accession number: Q9HFV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3