Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mannose-6-phosphate isomerase

Gene

MAN1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Mannose-6-phosphate isomerase (MAN1)
  2. Phosphomannomutase (CNH00170)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109ZincBy similarity1
Metal bindingi111ZincBy similarity1
Metal bindingi136ZincBy similarity1
Metal bindingi291ZincBy similarity1
Active sitei310By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00126; UER00423

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:MAN1
Ordered Locus Names:CNI02370
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:CNI02370

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001942431 – 434Mannose-6-phosphate isomeraseAdd BLAST434

Proteomic databases

PaxDbiQ9HFU4
PRIDEiQ9HFU4

Interactioni

Protein-protein interaction databases

STRINGi214684.XP_572705.1

Structurei

3D structure databases

ProteinModelPortaliQ9HFU4
SMRiQ9HFU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2757 Eukaryota
COG1482 LUCA
InParanoidiQ9HFU4
KOiK01809
OMAiMGTHPSN
OrthoDBiEOG092C3NWF

Family and domain databases

Gene3Di2.60.120.10, 4 hits
InterProiView protein in InterPro
IPR001250 Man6P_Isoase-1
IPR016305 Mannose-6-P_Isomerase
IPR018050 Pmannose_isomerase-type1_CS
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR10309 PTHR10309, 1 hit
PfamiView protein in Pfam
PF01238 PMI_typeI, 1 hit
PIRSFiPIRSF001480 Mannose-6-phosphate_isomerase, 1 hit
PRINTSiPR00714 MAN6PISMRASE
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR00218 manA, 1 hit
PROSITEiView protein in PROSITE
PS00965 PMI_I_1, 1 hit
PS00966 PMI_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HFU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPSVFKISP GINSYDWGKK GSASLAAQLA TTSIPDFSID EDKAYAELWM
60 70 80 90 100
GTHPNNPSRL SDNTLLSEHL KSHPELIGSS VSSKFEDCKD GSLPFLFKVL
110 120 130 140 150
SIGTALSIQA HPDKPLAKKL FDEKPDVYKD PNHKPEMAIA LTPFLAFLNF
160 170 180 190 200
LPLSVLLLHL LTVPELQEFV DSSLTESLAS SLGLPTSQPP DTSLFKPTES
210 220 230 240 250
PATAEQKDIL KQIFAALMSA DKKLVEEAIS KLIKRYQAKR DIKENEKSLV
260 270 280 290 300
DLALRLNDQY PGDVGVLCVF LLNVVELKRG EAAFLGANEP HAYIEGDIIE
310 320 330 340 350
CMATSDNVVR AGLTPKLRDV DTLVSMLTYE AAPGNKQLLQ PTPFQKGDDT
360 370 380 390 400
TKLYDPPIAE FSVLRTELSK GMKTSHRPVE GPSLCVITEG EGVVRNGNDR
410 420 430
SEFVRGDVIF VGAGKEVEWE AIKGLEMFRA YVEA
Length:434
Mass (Da):47,590
Last modified:June 21, 2005 - v2
Checksum:i4C2541EEFE9793FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38S → A in AAG10203 (PubMed:11359567).Curated1
Sequence conflicti43K → R in AAG10203 (PubMed:11359567).Curated1
Sequence conflicti71K → R in AAG10203 (PubMed:11359567).Curated1
Sequence conflicti79 – 80SS → TT in AAG10203 (PubMed:11359567).Curated2
Sequence conflicti154S → P in AAG10203 (PubMed:11359567).Curated1
Sequence conflicti183G → D in AAG10203 (PubMed:11359567).Curated1
Sequence conflicti192T → S in AAG10203 (PubMed:11359567).Curated1
Sequence conflicti224L → H in AAG10203 (PubMed:11359567).Curated1
Sequence conflicti237Q → K in AAG10203 (PubMed:11359567).Curated1
Sequence conflicti248S → D in AAG10203 (PubMed:11359567).Curated1
Sequence conflicti343P → S in AAG10203 (PubMed:11359567).Curated1
Sequence conflicti396N → D in AAG10203 (PubMed:11359567).Curated1
Sequence conflicti400 – 401RS → QT in AAG10203 (PubMed:11359567).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291701 Genomic DNA Translation: AAG10203.1
AE017349 Genomic DNA Translation: AAW45398.1
RefSeqiXP_572705.1, XM_572705.1

Genome annotation databases

EnsemblFungiiAAW45398; AAW45398; CNI02370
GeneIDi3259465
KEGGicne:CNI02370

Similar proteinsi

Entry informationi

Entry nameiMPI_CRYNJ
AccessioniPrimary (citable) accession number: Q9HFU4
Secondary accession number(s): Q5KBJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 21, 2005
Last modified: May 23, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health