SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9HFU4

- MPI_CRYNJ

UniProt

Q9HFU4 - MPI_CRYNJ

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Mannose-6-phosphate isomerase

Gene
MAN1, CNI02370
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi109 – 1091Zinc By similarity
Metal bindingi111 – 1111Zinc By similarity
Metal bindingi136 – 1361Zinc By similarity
Metal bindingi291 – 2911Zinc By similarity
Active sitei310 – 3101 By similarity

GO - Molecular functioni

  1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00126; UER00423.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:MAN1
Ordered Locus Names:CNI02370
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000002149: Chromosome 9

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Mannose-6-phosphate isomerasePRO_0000194243Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi214684.CNI02370.

Structurei

3D structure databases

ProteinModelPortaliQ9HFU4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1482.
KOiK01809.
OrthoDBiEOG7WDNCR.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR10309. PTHR10309. 1 hit.
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.
PROSITEiPS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HFU4-1 [UniParc]FASTAAdd to Basket

« Hide

MSPSVFKISP GINSYDWGKK GSASLAAQLA TTSIPDFSID EDKAYAELWM    50
GTHPNNPSRL SDNTLLSEHL KSHPELIGSS VSSKFEDCKD GSLPFLFKVL 100
SIGTALSIQA HPDKPLAKKL FDEKPDVYKD PNHKPEMAIA LTPFLAFLNF 150
LPLSVLLLHL LTVPELQEFV DSSLTESLAS SLGLPTSQPP DTSLFKPTES 200
PATAEQKDIL KQIFAALMSA DKKLVEEAIS KLIKRYQAKR DIKENEKSLV 250
DLALRLNDQY PGDVGVLCVF LLNVVELKRG EAAFLGANEP HAYIEGDIIE 300
CMATSDNVVR AGLTPKLRDV DTLVSMLTYE AAPGNKQLLQ PTPFQKGDDT 350
TKLYDPPIAE FSVLRTELSK GMKTSHRPVE GPSLCVITEG EGVVRNGNDR 400
SEFVRGDVIF VGAGKEVEWE AIKGLEMFRA YVEA 434
Length:434
Mass (Da):47,590
Last modified:June 21, 2005 - v2
Checksum:i4C2541EEFE9793FF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381S → A in AAG10203. 1 Publication
Sequence conflicti43 – 431K → R in AAG10203. 1 Publication
Sequence conflicti71 – 711K → R in AAG10203. 1 Publication
Sequence conflicti79 – 802SS → TT in AAG10203. 1 Publication
Sequence conflicti154 – 1541S → P in AAG10203. 1 Publication
Sequence conflicti183 – 1831G → D in AAG10203. 1 Publication
Sequence conflicti192 – 1921T → S in AAG10203. 1 Publication
Sequence conflicti224 – 2241L → H in AAG10203. 1 Publication
Sequence conflicti237 – 2371Q → K in AAG10203. 1 Publication
Sequence conflicti248 – 2481S → D in AAG10203. 1 Publication
Sequence conflicti343 – 3431P → S in AAG10203. 1 Publication
Sequence conflicti396 – 3961N → D in AAG10203. 1 Publication
Sequence conflicti400 – 4012RS → QT in AAG10203. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF291701 Genomic DNA. Translation: AAG10203.1.
AE017349 Genomic DNA. Translation: AAW45398.1.
RefSeqiXP_572705.1. XM_572705.1.

Genome annotation databases

EnsemblFungiiAAW45398; AAW45398; CNI02370.
GeneIDi3259465.
KEGGicne:CNI02370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF291701 Genomic DNA. Translation: AAG10203.1 .
AE017349 Genomic DNA. Translation: AAW45398.1 .
RefSeqi XP_572705.1. XM_572705.1.

3D structure databases

ProteinModelPortali Q9HFU4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214684.CNI02370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAW45398 ; AAW45398 ; CNI02370 .
GeneIDi 3259465.
KEGGi cne:CNI02370.

Phylogenomic databases

eggNOGi COG1482.
KOi K01809.
OrthoDBi EOG7WDNCR.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00423 .

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR10309. PTHR10309. 1 hit.
Pfami PF01238. PMI_typeI. 1 hit.
[Graphical view ]
PIRSFi PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSi PR00714. MAN6PISMRASE.
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR00218. manA. 1 hit.
PROSITEi PS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase-encoding gene, MAN1, and its impact on pathogenicity."
    Wills E.A., Roberts I.S., Del Poeta M., Rivera J., Casadevall A., Cox G.M., Perfect J.R.
    Mol. Microbiol. 40:610-620(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JEC21 / ATCC MYA-565.

Entry informationi

Entry nameiMPI_CRYNJ
AccessioniPrimary (citable) accession number: Q9HFU4
Secondary accession number(s): Q5KBJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 21, 2005
Last modified: November 13, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi