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Q9HFR6

- DHE4_TUBBO

UniProt

Q9HFR6 - DHE4_TUBBO

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Protein
NADP-specific glutamate dehydrogenase
Gene
GDH
Organism
Tuber borchii (White truffle)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei113 – 1131 By similarity

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Alternative name(s):
NADP-dependent glutamate dehydrogenase
Gene namesi
Name:GDH
OrganismiTuber borchii (White truffle)
Taxonomic identifieri42251 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457NADP-specific glutamate dehydrogenase
PRO_0000182795Add
BLAST

Proteomic databases

PRIDEiQ9HFR6.

Interactioni

Subunit structurei

Homohexamer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9HFR6.
SMRiQ9HFR6. Positions 5-456.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HFR6-1 [UniParc]FASTAAdd to Basket

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MSNLAPEPEF QQAYNELVHS LRDQNSSRLP QILRLLCLSS PPERVIQFRV    50
TWEDDKGNFQ VNRGYRVQFN SALGPYKGGL RFHPTVNLSI LKFLGFEQTF 100
KNALTGLNMG GGKGGSDFDP KGKSDNEIRR FCYSFMRELS KHIGQFTDVP 150
AGDIGVGGRE IGYLFGAYES YKNQFEGVLT GKGITWGGSL IRPEATGYGL 200
VYYVAHMISY ASGGKETFAG KRVAISGSGN VAQYAALKVL ELGGKVITLS 250
DSKGALIATG EEGFNETDIE LIAKLKLDRG YLTQLHAAED SFKSRFKYLP 300
GERPWCHVDK VDVALPSATQ NEVSEQEAKE LIASGCKFLA EGSNMGSTQE 350
AINVYEEDRK SRKADGLWYG PAKAANCGGV AVSGLEMAQN SQRLTWTSEQ 400
VDKELAGIME RCFWNCLNPA KEYFDIAEGE LPSLVAGANI AGYVKVVNAM 450
KAQGDWW 457
Length:457
Mass (Da):50,155
Last modified:March 1, 2001 - v1
Checksum:iC32DE331D01DF612
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF309087 Genomic DNA. Translation: AAG28788.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF309087 Genomic DNA. Translation: AAG28788.1 .

3D structure databases

ProteinModelPortali Q9HFR6.
SMRi Q9HFR6. Positions 5-456.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9HFR6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Biochemical and molecular characterization of NADP-glutamate dehydrogenase from the ectomycorrhizal fungus Tuber borchii."
    Vallorani L., Polidori E., Sacconi C., Agostini D., Pierleoni R., Piccoli G., Zeppa S., Stocchi V.
    New Phytol. 154:779-790(2002)
    [AGRICOLA] [Europe PMC]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDHE4_TUBBO
AccessioniPrimary (citable) accession number: Q9HFR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2001
Last modified: October 16, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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