Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9HFR6 (DHE4_TUBBO) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADP-specific glutamate dehydrogenase

Short name=NADP-GDH
EC=1.4.1.4
Alternative name(s):
NADP-dependent glutamate dehydrogenase
Gene names
Name:GDH
OrganismTuber borchii (White truffle)
Taxonomic identifier42251 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Subunit structure

Homohexamer By similarity.

Sequence similarities

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processcellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutamate dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457NADP-specific glutamate dehydrogenase
PRO_0000182795

Sites

Active site1131 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HFR6 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: C32DE331D01DF612

FASTA45750,155
        10         20         30         40         50         60 
MSNLAPEPEF QQAYNELVHS LRDQNSSRLP QILRLLCLSS PPERVIQFRV TWEDDKGNFQ 

        70         80         90        100        110        120 
VNRGYRVQFN SALGPYKGGL RFHPTVNLSI LKFLGFEQTF KNALTGLNMG GGKGGSDFDP 

       130        140        150        160        170        180 
KGKSDNEIRR FCYSFMRELS KHIGQFTDVP AGDIGVGGRE IGYLFGAYES YKNQFEGVLT 

       190        200        210        220        230        240 
GKGITWGGSL IRPEATGYGL VYYVAHMISY ASGGKETFAG KRVAISGSGN VAQYAALKVL 

       250        260        270        280        290        300 
ELGGKVITLS DSKGALIATG EEGFNETDIE LIAKLKLDRG YLTQLHAAED SFKSRFKYLP 

       310        320        330        340        350        360 
GERPWCHVDK VDVALPSATQ NEVSEQEAKE LIASGCKFLA EGSNMGSTQE AINVYEEDRK 

       370        380        390        400        410        420 
SRKADGLWYG PAKAANCGGV AVSGLEMAQN SQRLTWTSEQ VDKELAGIME RCFWNCLNPA 

       430        440        450 
KEYFDIAEGE LPSLVAGANI AGYVKVVNAM KAQGDWW 

« Hide

References

[1]"Biochemical and molecular characterization of NADP-glutamate dehydrogenase from the ectomycorrhizal fungus Tuber borchii."
Vallorani L., Polidori E., Sacconi C., Agostini D., Pierleoni R., Piccoli G., Zeppa S., Stocchi V.
New Phytol. 154:779-790(2002) [AGRICOLA] [Europe PMC]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF309087 Genomic DNA. Translation: AAG28788.1.

3D structure databases

ProteinModelPortalQ9HFR6.
SMRQ9HFR6. Positions 5-456.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9HFR6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFPIRSF000185. Glu_DH. 1 hit.
PRINTSPR00082. GLFDHDRGNASE.
SMARTSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHE4_TUBBO
AccessionPrimary (citable) accession number: Q9HFR6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2001
Last modified: October 16, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families