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Q9HFR6

- DHE4_TUBBO

UniProt

Q9HFR6 - DHE4_TUBBO

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Protein

NADP-specific glutamate dehydrogenase

Gene

GDH

Organism
Tuber borchii (White truffle)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei113 – 1131PROSITE-ProRule annotation

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Alternative name(s):
NADP-dependent glutamate dehydrogenase
Gene namesi
Name:GDH
OrganismiTuber borchii (White truffle)
Taxonomic identifieri42251 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaPezizomycetesPezizalesTuberaceaeTuber

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457NADP-specific glutamate dehydrogenasePRO_0000182795Add
BLAST

Proteomic databases

PRIDEiQ9HFR6.

Interactioni

Subunit structurei

Homohexamer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9HFR6.
SMRiQ9HFR6. Positions 5-456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HFR6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNLAPEPEF QQAYNELVHS LRDQNSSRLP QILRLLCLSS PPERVIQFRV
60 70 80 90 100
TWEDDKGNFQ VNRGYRVQFN SALGPYKGGL RFHPTVNLSI LKFLGFEQTF
110 120 130 140 150
KNALTGLNMG GGKGGSDFDP KGKSDNEIRR FCYSFMRELS KHIGQFTDVP
160 170 180 190 200
AGDIGVGGRE IGYLFGAYES YKNQFEGVLT GKGITWGGSL IRPEATGYGL
210 220 230 240 250
VYYVAHMISY ASGGKETFAG KRVAISGSGN VAQYAALKVL ELGGKVITLS
260 270 280 290 300
DSKGALIATG EEGFNETDIE LIAKLKLDRG YLTQLHAAED SFKSRFKYLP
310 320 330 340 350
GERPWCHVDK VDVALPSATQ NEVSEQEAKE LIASGCKFLA EGSNMGSTQE
360 370 380 390 400
AINVYEEDRK SRKADGLWYG PAKAANCGGV AVSGLEMAQN SQRLTWTSEQ
410 420 430 440 450
VDKELAGIME RCFWNCLNPA KEYFDIAEGE LPSLVAGANI AGYVKVVNAM

KAQGDWW
Length:457
Mass (Da):50,155
Last modified:March 1, 2001 - v1
Checksum:iC32DE331D01DF612
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF309087 Genomic DNA. Translation: AAG28788.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF309087 Genomic DNA. Translation: AAG28788.1 .

3D structure databases

ProteinModelPortali Q9HFR6.
SMRi Q9HFR6. Positions 5-456.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9HFR6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Biochemical and molecular characterization of NADP-glutamate dehydrogenase from the ectomycorrhizal fungus Tuber borchii."
    Vallorani L., Polidori E., Sacconi C., Agostini D., Pierleoni R., Piccoli G., Zeppa S., Stocchi V.
    New Phytol. 154:779-790(2002)
    [AGRICOLA] [Europe PMC]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDHE4_TUBBO
AccessioniPrimary (citable) accession number: Q9HFR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2001
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3