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Protein

Serine/threonine-protein phosphatase PP2A catalytic subunit

Gene

pphA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in hyphal morphogenesis.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi77 – 771Manganese 1By similarity
Metal bindingi79 – 791Manganese 1By similarity
Metal bindingi105 – 1051Manganese 1By similarity
Metal bindingi105 – 1051Manganese 2By similarity
Metal bindingi137 – 1371Manganese 2By similarity
Active sitei138 – 1381Proton donorBy similarity
Metal bindingi187 – 1871Manganese 2By similarity
Metal bindingi261 – 2611Manganese 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit (EC:3.1.3.16)
Short name:
Protein phosphatase 2a
Gene namesi
Name:pphA
ORF Names:AN6391
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Serine/threonine-protein phosphatase PP2A catalytic subunitPRO_0000058868Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei329 – 3291Leucine methyl esterBy similarity

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiQ9HFQ2.

Structurei

3D structure databases

ProteinModelPortaliQ9HFQ2.
SMRiQ9HFQ2. Positions 30-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.
InParanoidiQ9HFQ2.
KOiK04382.
OMAiKEVDQWI.
OrthoDBiEOG7FFN29.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HFQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNNMEIDAA RSPEPHHLSP TTDPGSIPTL DGWIESLMTC KQLAEEDVRR
60 70 80 90 100
LCDRAREVLQ EESNVQPVKC PVTVCGDIHG QFHDLMELFR IGGPNPDTNY
110 120 130 140 150
LFMGDYVDRG YYSVETVTLL VCLKIRYPQR ITILRGNHES RQITQVYGFY
160 170 180 190 200
DECLRKYGNA NVWKYFTDLF DYLPLTALIE NQIFCLHGGL SPSIDTLDNI
210 220 230 240 250
RSLDRIQEVP HEGPMCDLLW SDPDDRCGWG ISPRGAGYTF GQDISEAFNH
260 270 280 290 300
NNGLTLVARA HQLVMEGYNW SQDRNVVTIF SAPNYCYRCG NQAAIMEIDE
310 320
HLKYTFLQFD PCPRAGEPMV SRRTPDYFL
Length:329
Mass (Da):37,665
Last modified:May 1, 2007 - v2
Checksum:i79308C0B11E95E23
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331I → T in CAC13980 (PubMed:11318104).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291510 Genomic DNA. Translation: CAC13980.1.
AACD01000108 Genomic DNA. Translation: EAA58413.1.
BN001301 Genomic DNA. Translation: CBF69560.1.
RefSeqiXP_663995.1. XM_658903.1.

Genome annotation databases

EnsemblFungiiCADANIAT00006588; CADANIAP00006588; CADANIAG00006588.
GeneIDi2871291.
KEGGiani:AN6391.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291510 Genomic DNA. Translation: CAC13980.1.
AACD01000108 Genomic DNA. Translation: EAA58413.1.
BN001301 Genomic DNA. Translation: CBF69560.1.
RefSeqiXP_663995.1. XM_658903.1.

3D structure databases

ProteinModelPortaliQ9HFQ2.
SMRiQ9HFQ2. Positions 30-329.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9HFQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00006588; CADANIAP00006588; CADANIAG00006588.
GeneIDi2871291.
KEGGiani:AN6391.2.

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.
InParanoidiQ9HFQ2.
KOiK04382.
OMAiKEVDQWI.
OrthoDBiEOG7FFN29.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A type 2A protein phosphatase gene from Aspergillus nidulans is involved in hyphal morphogenesis."
    Kosmidou E., Lunness P., Doonan J.H.
    Curr. Genet. 39:25-34(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiPP2A1_EMENI
AccessioniPrimary (citable) accession number: Q9HFQ2
Secondary accession number(s): C8V0P5, Q5AZ89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: May 1, 2007
Last modified: July 22, 2015
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.