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Protein

Serine/threonine-protein phosphatase PP2A catalytic subunit

Gene

pphA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in hyphal morphogenesis.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi77Manganese 1By similarity1
Metal bindingi79Manganese 1By similarity1
Metal bindingi105Manganese 1By similarity1
Metal bindingi105Manganese 2By similarity1
Metal bindingi137Manganese 2By similarity1
Active sitei138Proton donorBy similarity1
Metal bindingi187Manganese 2By similarity1
Metal bindingi261Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit (EC:3.1.3.16)
Short name:
Protein phosphatase 2a
Gene namesi
Name:pphA
ORF Names:AN6391
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome I
  • UP000005890 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588681 – 329Serine/threonine-protein phosphatase PP2A catalytic subunitAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei329Leucine methyl esterBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiQ9HFQ2

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00006588

Structurei

3D structure databases

ProteinModelPortaliQ9HFQ2
SMRiQ9HFQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000172696
InParanoidiQ9HFQ2
KOiK04382
OMAiNKIFCPH
OrthoDBiEOG092C2R40

Family and domain databases

Gene3Di3.60.21.101 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HFQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNNMEIDAA RSPEPHHLSP TTDPGSIPTL DGWIESLMTC KQLAEEDVRR
60 70 80 90 100
LCDRAREVLQ EESNVQPVKC PVTVCGDIHG QFHDLMELFR IGGPNPDTNY
110 120 130 140 150
LFMGDYVDRG YYSVETVTLL VCLKIRYPQR ITILRGNHES RQITQVYGFY
160 170 180 190 200
DECLRKYGNA NVWKYFTDLF DYLPLTALIE NQIFCLHGGL SPSIDTLDNI
210 220 230 240 250
RSLDRIQEVP HEGPMCDLLW SDPDDRCGWG ISPRGAGYTF GQDISEAFNH
260 270 280 290 300
NNGLTLVARA HQLVMEGYNW SQDRNVVTIF SAPNYCYRCG NQAAIMEIDE
310 320
HLKYTFLQFD PCPRAGEPMV SRRTPDYFL
Length:329
Mass (Da):37,665
Last modified:May 1, 2007 - v2
Checksum:i79308C0B11E95E23
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133I → T in CAC13980 (PubMed:11318104).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291510 Genomic DNA Translation: CAC13980.1
AACD01000108 Genomic DNA Translation: EAA58413.1
BN001301 Genomic DNA Translation: CBF69560.1
RefSeqiXP_663995.1, XM_658903.1

Genome annotation databases

EnsemblFungiiCADANIAT00006588; CADANIAP00006588; CADANIAG00006588
EAA58413; EAA58413; AN6391.2
GeneIDi2871291
KEGGiani:AN6391.2

Similar proteinsi

Entry informationi

Entry nameiPP2A1_EMENI
AccessioniPrimary (citable) accession number: Q9HFQ2
Secondary accession number(s): C8V0P5, Q5AZ89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: May 1, 2007
Last modified: March 28, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome