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Q9HFQ2

- PP2A1_EMENI

UniProt

Q9HFQ2 - PP2A1_EMENI

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Protein
Serine/threonine-protein phosphatase PP2A catalytic subunit
Gene
pphA, AN6391
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in hyphal morphogenesis.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi77 – 771Manganese 1 By similarity
Metal bindingi79 – 791Manganese 1 By similarity
Metal bindingi105 – 1051Manganese 1 By similarity
Metal bindingi105 – 1051Manganese 2 By similarity
Metal bindingi137 – 1371Manganese 2 By similarity
Active sitei138 – 1381Proton donor By similarity
Metal bindingi187 – 1871Manganese 2 By similarity
Metal bindingi261 – 2611Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit (EC:3.1.3.16)
Short name:
Protein phosphatase 2a
Gene namesi
Name:pphA
ORF Names:AN6391
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Serine/threonine-protein phosphatase PP2A catalytic subunit
PRO_0000058868Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei329 – 3291Leucine methyl ester By similarity

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiQ9HFQ2.

Structurei

3D structure databases

ProteinModelPortaliQ9HFQ2.
SMRiQ9HFQ2. Positions 30-329.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.
KOiK04382.
OMAiQVKTLCD.
OrthoDBiEOG7FFN29.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HFQ2-1 [UniParc]FASTAAdd to Basket

« Hide

MDNNMEIDAA RSPEPHHLSP TTDPGSIPTL DGWIESLMTC KQLAEEDVRR    50
LCDRAREVLQ EESNVQPVKC PVTVCGDIHG QFHDLMELFR IGGPNPDTNY 100
LFMGDYVDRG YYSVETVTLL VCLKIRYPQR ITILRGNHES RQITQVYGFY 150
DECLRKYGNA NVWKYFTDLF DYLPLTALIE NQIFCLHGGL SPSIDTLDNI 200
RSLDRIQEVP HEGPMCDLLW SDPDDRCGWG ISPRGAGYTF GQDISEAFNH 250
NNGLTLVARA HQLVMEGYNW SQDRNVVTIF SAPNYCYRCG NQAAIMEIDE 300
HLKYTFLQFD PCPRAGEPMV SRRTPDYFL 329
Length:329
Mass (Da):37,665
Last modified:May 1, 2007 - v2
Checksum:i79308C0B11E95E23
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331I → T in CAC13980. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ291510 Genomic DNA. Translation: CAC13980.1.
AACD01000108 Genomic DNA. Translation: EAA58413.1.
BN001301 Genomic DNA. Translation: CBF69560.1.
RefSeqiXP_663995.1. XM_658903.1.

Genome annotation databases

EnsemblFungiiCADANIAT00006588; CADANIAP00006588; CADANIAG00006588.
GeneIDi2871291.
KEGGiani:AN6391.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ291510 Genomic DNA. Translation: CAC13980.1 .
AACD01000108 Genomic DNA. Translation: EAA58413.1 .
BN001301 Genomic DNA. Translation: CBF69560.1 .
RefSeqi XP_663995.1. XM_658903.1.

3D structure databases

ProteinModelPortali Q9HFQ2.
SMRi Q9HFQ2. Positions 30-329.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9HFQ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00006588 ; CADANIAP00006588 ; CADANIAG00006588 .
GeneIDi 2871291.
KEGGi ani:AN6391.2.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000172696.
KOi K04382.
OMAi QVKTLCD.
OrthoDBi EOG7FFN29.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A type 2A protein phosphatase gene from Aspergillus nidulans is involved in hyphal morphogenesis."
    Kosmidou E., Lunness P., Doonan J.H.
    Curr. Genet. 39:25-34(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiPP2A1_EMENI
AccessioniPrimary (citable) accession number: Q9HFQ2
Secondary accession number(s): C8V0P5, Q5AZ89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: May 1, 2007
Last modified: June 11, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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