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Q9HFN9 (PYRF_CANRU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
OrganismCandida rugosa (Yeast) (Candida cylindracea)
Taxonomic identifier5481 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Orotidine 5'-phosphate decarboxylase
PRO_0000134653

Regions

Region59 – 613Substrate binding By similarity
Region91 – 10010Substrate binding By similarity

Sites

Active site931Proton donor By similarity
Binding site371Substrate By similarity
Binding site2171Substrate By similarity
Binding site2351Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HFN9 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 0A2F0D013F8DD499

FASTA26528,633
        10         20         30         40         50         60 
MPAPSYSTRA AAHPSPVARK LLALMDEKKS NLCASVDVTT TAELLALVEK LAPYICMVKT 

        70         80         90        100        110        120 
HIDIVSDFSY EGTVVPLVAL AKKHRFLLFE DRKFADIGNT VKHQYAGGVY QIARWADITN 

       130        140        150        160        170        180 
AHGVTGAGIV AGLKQAAEET TSEPRGLLML AELSSKGAIA HGKYTEETVE IAKTDKEFVF 

       190        200        210        220        230        240 
GFIAQGDMGG REEGFDWVVM TPGVGLDDTG DALGQQYRTV DTVVQTGTDV IIVGRGLFGK 

       250        260 
GRHPAVEGER YRKAGWDAYT KRVSP 

« Hide

References

[1]Biasio W.
Thesis (2000), University of Vienna, Austria
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ279021 Genomic DNA. Translation: CAC08811.1.

3D structure databases

ProteinModelPortalQ9HFN9.
SMRQ9HFN9. Positions 1-262.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_CANRU
AccessionPrimary (citable) accession number: Q9HFN9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: October 16, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways