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Q9HFN2

- ACEA_CYBJA

UniProt

Q9HFN2 - ACEA_CYBJA

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Protein

Isocitrate lyase

Gene

ICL1

Organism
Cyberlindnera jadinii (Torula yeast) (Pichia jadinii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei210 – 2101PROSITE-ProRule annotation

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
Gene namesi
Name:ICL1
Synonyms:ICL
OrganismiCyberlindnera jadinii (Torula yeast) (Pichia jadinii)
Taxonomic identifieri4903 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeCyberlindnera

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Isocitrate lyasePRO_0000068796Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9HFN2.
SMRiQ9HFN2. Positions 8-527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi548 – 5503Microbody targeting signalSequence Analysis

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HFN2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPYTPIDIKA EQEAFEREVA AVEQWWKEPR WRKTTRIYTA KDIVQKRGTL
60 70 80 90 100
QIHYPSSDQA KKLYKLLEEH DRNKTASFTF GALDPIHVTQ MAKYLDTVYI
110 120 130 140 150
SGWQSSSTAS TSNEPSPDLA DYPYDTVPNK CEHLWFAQLF HDRKQHEERF
160 170 180 190 200
RMTPEERAKT PYTDFLRPII ADADTGHGGI TAIIKLTKLF IERGAAGIHI
210 220 230 240 250
EDQAPGTKKC GHMAGKVLVP IQEHINRLVA IRTAADIFGS DLLCVARTDS
260 270 280 290 300
EAATLLTSTI DHRDHYFIIG STNKDLQPLS EVMFQAEQRG LLKVMLAAVE
310 320 330 340 350
EDWTKKAGLK LFHEAVIDEI NSGYYPNKQA LIAEFTTKVH PLSNTSNKEA
360 370 380 390 400
RALAKKLTGK DIFFDWEAPR VREGYYRYQG GTQCAVNRAR AYAPYADIIW
410 420 430 440 450
MESKLPDYAQ AKEFADGVKA QWPEQWLSYN LSPSFNWNKA MSVLYQETYI
460 470 480 490 500
QKLAKLGYVW QFITLAGLHT TALAVDNFAR DYAKIGMRAY GQQIQAPEIE
510 520 530 540 550
NGVEVVKHQK WSGAEYIDNL LKLVTGGVTS TAAMGKGVTE DQFKDDKSKL
Length:550
Mass (Da):62,394
Last modified:March 1, 2001 - v1
Checksum:i495D6179D8D1629C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404885 Genomic DNA. Translation: CAC08487.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404885 Genomic DNA. Translation: CAC08487.1 .

3D structure databases

ProteinModelPortali Q9HFN2.
SMRi Q9HFN2. Positions 8-527.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00719 .

Family and domain databases

Gene3Di 3.20.20.60. 2 hits.
InterProi IPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
Pfami PF00463. ICL. 1 hit.
[Graphical view ]
PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The ICL gene from Camdida utilis."
    Menendez J.D.D.J., Rivero D., Valdes I.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 9256 / CBS 841 / DSM 70167 / JCM 2311 / NBRC 0626 / NRRL Y-1084 / VKM Y-768.

Entry informationi

Entry nameiACEA_CYBJA
AccessioniPrimary (citable) accession number: Q9HFN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3