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Q9HFN2 (ACEA_CYBJA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate lyase
Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
Gene names
Name:ICL1
Synonyms:ICL
OrganismCyberlindnera jadinii (Torula yeast) (Pichia jadinii)
Taxonomic identifier4903 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Phaffomycetaceae › Cyberlindnera

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentPeroxisome
   Molecular functionLyase
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Isocitrate lyase
PRO_0000068796

Regions

Motif548 – 5503Microbody targeting signal Potential

Sites

Active site2101 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9HFN2 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 495D6179D8D1629C

FASTA55062,394
        10         20         30         40         50         60 
MPYTPIDIKA EQEAFEREVA AVEQWWKEPR WRKTTRIYTA KDIVQKRGTL QIHYPSSDQA 

        70         80         90        100        110        120 
KKLYKLLEEH DRNKTASFTF GALDPIHVTQ MAKYLDTVYI SGWQSSSTAS TSNEPSPDLA 

       130        140        150        160        170        180 
DYPYDTVPNK CEHLWFAQLF HDRKQHEERF RMTPEERAKT PYTDFLRPII ADADTGHGGI 

       190        200        210        220        230        240 
TAIIKLTKLF IERGAAGIHI EDQAPGTKKC GHMAGKVLVP IQEHINRLVA IRTAADIFGS 

       250        260        270        280        290        300 
DLLCVARTDS EAATLLTSTI DHRDHYFIIG STNKDLQPLS EVMFQAEQRG LLKVMLAAVE 

       310        320        330        340        350        360 
EDWTKKAGLK LFHEAVIDEI NSGYYPNKQA LIAEFTTKVH PLSNTSNKEA RALAKKLTGK 

       370        380        390        400        410        420 
DIFFDWEAPR VREGYYRYQG GTQCAVNRAR AYAPYADIIW MESKLPDYAQ AKEFADGVKA 

       430        440        450        460        470        480 
QWPEQWLSYN LSPSFNWNKA MSVLYQETYI QKLAKLGYVW QFITLAGLHT TALAVDNFAR 

       490        500        510        520        530        540 
DYAKIGMRAY GQQIQAPEIE NGVEVVKHQK WSGAEYIDNL LKLVTGGVTS TAAMGKGVTE 

       550 
DQFKDDKSKL

« Hide

References

[1]"The ICL gene from Camdida utilis."
Menendez J.D.D.J., Rivero D., Valdes I.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 9256 / CBS 841 / DSM 70167 / JCM 2311 / NBRC 0626 / NRRL Y-1084 / VKM Y-768.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ404885 Genomic DNA. Translation: CAC08487.1.

3D structure databases

ProteinModelPortalQ9HFN2.
SMRQ9HFN2. Positions 8-527.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR000918. Isocitrate_lyase/Pmutase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA_CYBJA
AccessionPrimary (citable) accession number: Q9HFN2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: March 1, 2001
Last modified: March 6, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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