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Q9HFN2

- ACEA_CYBJA

UniProt

Q9HFN2 - ACEA_CYBJA

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Protein
Isocitrate lyase
Gene
ICL1, ICL
Organism
Cyberlindnera jadinii (Torula yeast) (Pichia jadinii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate = succinate + glyoxylate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei210 – 2101 By similarity

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
Gene namesi
Name:ICL1
Synonyms:ICL
OrganismiCyberlindnera jadinii (Torula yeast) (Pichia jadinii)
Taxonomic identifieri4903 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeCyberlindnera

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Isocitrate lyase
PRO_0000068796Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9HFN2.
SMRiQ9HFN2. Positions 8-527.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi548 – 5503Microbody targeting signal Reviewed prediction

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HFN2-1 [UniParc]FASTAAdd to Basket

« Hide

MPYTPIDIKA EQEAFEREVA AVEQWWKEPR WRKTTRIYTA KDIVQKRGTL    50
QIHYPSSDQA KKLYKLLEEH DRNKTASFTF GALDPIHVTQ MAKYLDTVYI 100
SGWQSSSTAS TSNEPSPDLA DYPYDTVPNK CEHLWFAQLF HDRKQHEERF 150
RMTPEERAKT PYTDFLRPII ADADTGHGGI TAIIKLTKLF IERGAAGIHI 200
EDQAPGTKKC GHMAGKVLVP IQEHINRLVA IRTAADIFGS DLLCVARTDS 250
EAATLLTSTI DHRDHYFIIG STNKDLQPLS EVMFQAEQRG LLKVMLAAVE 300
EDWTKKAGLK LFHEAVIDEI NSGYYPNKQA LIAEFTTKVH PLSNTSNKEA 350
RALAKKLTGK DIFFDWEAPR VREGYYRYQG GTQCAVNRAR AYAPYADIIW 400
MESKLPDYAQ AKEFADGVKA QWPEQWLSYN LSPSFNWNKA MSVLYQETYI 450
QKLAKLGYVW QFITLAGLHT TALAVDNFAR DYAKIGMRAY GQQIQAPEIE 500
NGVEVVKHQK WSGAEYIDNL LKLVTGGVTS TAAMGKGVTE DQFKDDKSKL 550
Length:550
Mass (Da):62,394
Last modified:March 1, 2001 - v1
Checksum:i495D6179D8D1629C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ404885 Genomic DNA. Translation: CAC08487.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ404885 Genomic DNA. Translation: CAC08487.1 .

3D structure databases

ProteinModelPortali Q9HFN2.
SMRi Q9HFN2. Positions 8-527.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00719 .

Family and domain databases

Gene3Di 3.20.20.60. 2 hits.
InterProi IPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
Pfami PF00463. ICL. 1 hit.
[Graphical view ]
PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The ICL gene from Camdida utilis."
    Menendez J.D.D.J., Rivero D., Valdes I.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 9256 / CBS 841 / DSM 70167 / JCM 2311 / NBRC 0626 / NRRL Y-1084 / VKM Y-768.

Entry informationi

Entry nameiACEA_CYBJA
AccessioniPrimary (citable) accession number: Q9HFN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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