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Protein

Transcription-associated protein 1

Gene

tra1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential component of histone acetyltransferase (HAT) complexes, which serves as a target for activators during recruitment of HAT complexes. Essential for vegetative growth. Functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription-associated protein 1
Gene namesi
Name:tra1
ORF Names:SPBP16F5.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP16F5.03c.
PomBaseiSPBP16F5.03c. tra1.

Subcellular locationi

GO - Cellular componenti

  • ASTRA complex Source: PomBase
  • SAGA complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 36993699Transcription-associated protein 1PRO_0000314773Add
BLAST

Proteomic databases

MaxQBiQ9HFE8.

Interactioni

Subunit structurei

Component of the SAGA complex.By similarity

Protein-protein interaction databases

BioGridi277779. 33 interactions.
IntActiQ9HFE8. 24 interactions.
MINTiMINT-8210490.

Structurei

3D structure databases

ProteinModelPortaliQ9HFE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati314 – 34734TPR 1Add
BLAST
Repeati2082 – 211433TPR 2Add
BLAST
Domaini2546 – 3107562FATPROSITE-ProRule annotationAdd
BLAST
Repeati2610 – 264334TPR 3Add
BLAST
Domaini3361 – 3680320PI3K/PI4KAdd
BLAST
Domaini3667 – 369933FATCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. TRA1 subfamily.Curated
Contains 1 FAT domain.PROSITE-ProRule annotation
Contains 1 FATC domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.Curated
Contains 3 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

HOGENOMiHOG000160814.
InParanoidiQ9HFE8.
KOiK08874.
OMAiERSQNIK.
OrthoDBiEOG7PCJR4.
PhylomeDBiQ9HFE8.

Family and domain databases

Gene3Di1.10.1070.11. 2 hits.
1.25.10.10. 4 hits.
1.25.40.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR011990. TPR-like_helical_dom.
IPR033317. TRA1/TRRAP.
[Graphical view]
PANTHERiPTHR11139:SF1. PTHR11139:SF1. 6 hits.
PfamiPF02259. FAT. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 13 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HFE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLALSHNIP IVIVKYLGKR IRVQLEFKKE LAQRSKHLMD VSQCEHWHNR
60 70 80 90 100
LCDVGLDSKQ KANTAIEIRD ALDDVLVTEK TNFETFIPLL EDTLSLLEKE
110 120 130 140 150
RPVFSSLAAT HRLRIALLEL LKKSGSYKGF EAFVNRTFAV LLRIVVNDNE
160 170 180 190 200
EMAVLALKLV VLLFKDHSSL AKGHVQEFLS IVVENYKSMT TVVSEAFPPR
210 220 230 240 250
SAPNTPSSHP MSAASSASPA EIGMEHAGPK MIPKASSSFK VTAEFPIIVF
260 270 280 290 300
LLFQTYKDLI PKMLPLLAPL VLQFISLRPP PQAEARRLAE SQKEVFIGVV
310 320 330 340 350
PSLRRNHLYN DLISAQIKSF SFLAYLLRSF GAALKQFESS IPICTLQLFM
360 370 380 390 400
DCPSELYQTR RELLVATRHV LSTDYLRGFL PYVDQLLDTK ILVGSGITSQ
410 420 430 440 450
HSLRPMAFSM LADMLHYVRM ELSPQQIYKV ILLYFSILMD DFYTSAIQAM
460 470 480 490 500
ATKLILNLVE RIVALEDFST SRSLLFAILL CLLRKLTSLN FEFMKLRDSL
510 520 530 540 550
QENADLKQIK IEENKHDLPM FENPTGAAQP SGLDKLKDCI FLFKNTLLGI
560 570 580 590 600
KPVLFGLKQR NIPLANGSIF TAQEWSEKLH LSSTNEVLLF RRLLVESLKG
610 620 630 640 650
FSYYQTDEKT GVFKSSKNLA YSQLDSSLTT NPSKLLEEKE LLEMLATLFL
660 670 680 690 700
HLDPSVFVEI LESEFPNIFE CLVDNLALLH IFQFWMSNEV TSVNCTGIVL
710 720 730 740 750
SFCCDNLAKI GSGQSTRVSV LLRLFKLAFM TVNVFPEKNA EVLRPHISYI
760 770 780 790 800
ISTSLELTTD AVEPLNYVYL MKALFRNISG GKFDSLYKEI LPLLQVMLEC
810 820 830 840 850
FNRLIFTVTS TSQKELYAEL CLTLPIRLSV LLPHMNFLMK PLIVALKGPP
860 870 880 890 900
EIASQGLRIF ELCLDNLTQE FLDPLLDSIM PDLLICLWNH SRLNQSNNQL
910 920 930 940 950
HQSAVRILGK MGGRNRQIYL GTFGFDFLQD ENIFPSIQFS FQGSSQNFSL
960 970 980 990 1000
EHSKFLMSSC AVLNNQNSDL EEKKQAFQMV KNSYLLLFAS AKPDEDFWES
1010 1020 1030 1040 1050
IDTMCRAVVD RMDKNLQQVS NGRLCPDKDE SYYLQRSIVS NIFKSLVGSM
1060 1070 1080 1090 1100
SCVEFVAEAR ETINRSLEWL IVLDLVNYAD SLQIKDQNIF DNLQSIKMLD
1110 1120 1130 1140 1150
LTTCINGIFE SLCSENENTR SNALSCIDHY LNAHKMLLNT TLDISKLPSF
1160 1170 1180 1190 1200
QNLVTVFCQS CHKELWYQKN AGFLGLKAIL SYDSHHKLWI QDRLHDILKA
1210 1220 1230 1240 1250
LFFILKDTPT DYGVLKLTEV RSFIVDITTQ FCILQDVLAP KERANNIINA
1260 1270 1280 1290 1300
FSPFFLELLH PNDHVRNTVQ QAIENISNNS KLSVVDLLLP IKDRLLSPIF
1310 1320 1330 1340 1350
GKPLRALPFT IQIGHIDAIT YCLHRSPSFL DLTDELYRLF RETIALADAE
1360 1370 1380 1390 1400
DEALVTMLKT SQSKDSSSLR KLRATCLHLL FASLVAHKFD QPQHAQTRTK
1410 1420 1430 1440 1450
IIAIFFKDLY SPHKEIYSVA IDALRHVLSQ NQKLPKELLQ SGLRPILMNL
1460 1470 1480 1490 1500
SDHNKLSVNG LEGLSRLLRL LTNYFKVEIG RKLLQHLNVL SDSKVLETAS
1510 1520 1530 1540 1550
LSLLKTNPRI EIIVSLVNVF RDLPPLSAQF LGDLLSSVVN IEAVLRKYSN
1560 1570 1580 1590 1600
SPLRKPLYSF MDLHANDTWM YILNNARNGD LITRFVGALN DPMSEKLRET
1610 1620 1630 1640 1650
AGNYWGKLLE LISQPVSVEN LAPMYAVDII ATVFPYISAN VDAGVISAKF
1660 1670 1680 1690 1700
IVLSKSLYGM LSSYNEYLFL PIRRCISSIT KMLLSSLKKI EKKLEFSLEV
1710 1720 1730 1740 1750
FRFKADDDND FLPEYIDSLC GCLITSTSAA EKKSIFLVCC SIVGDKSVRP
1760 1770 1780 1790 1800
FFKAFLLDKV INPLVFKSCG ENNFIDKDVV HSVYTHVWRV SIRDFAEVSG
1810 1820 1830 1840 1850
ATDSFYMGIM CLTTALCKYH SALLNDYRKS VIMSAWNYIK LEDPMVKQAA
1860 1870 1880 1890 1900
YATIACFISA YDTPAKIVTP VYVSILKTYQ PEVRAFIEFS LASLLSVLTA
1910 1920 1930 1940 1950
RLSSPSDSTF PLWAKLPRLV ISEDVQGISQ PLTVYQFICK APDLFFSCCS
1960 1970 1980 1990 2000
HFIVPMVNAL PKLVSFSSAS TEPRKLALDI VQTFINWQRK QNESENSETT
2010 2020 2030 2040 2050
LFSNSHIEAI LTFLIKFLSL FPEPVEENPL SKKGLSLFND LFSFPRWKDC
2060 2070 2080 2090 2100
QLNSNFFEKI LVDMDFNDNN YRTVANTLFV FGVILKNRGM EYIQREYSHI
2110 2120 2130 2140 2150
IALIDKSLRC GKLPVTHSLE QIILLLLQSH PTQAEEEEDT NEADDFKQLL
2160 2170 2180 2190 2200
LSVIHDNLAA ATNIESAICY LQIVKSSNPE ALDGLLLPLN KCFQKVARDH
2210 2220 2230 2240 2250
IVACMQSAIQ ASGKVTLPSA SDTVSKLLIS FIEIIRVRMA SLGDQRRWFL
2260 2270 2280 2290 2300
SVVVQLLEKS SSFELCEHIL NVTKEWVIVK RDSFLTVKEK TALLLKMRTF
2310 2320 2330 2340 2350
EGRFDNKLYI EACDLLSTIY RDPIFAHTEL TARLKQAFLL ATASKDTKIR
2360 2370 2380 2390 2400
MDFMDIFDSS MSRNVYSRLT FILDATSWDT IPSIYWIKQA NYILLGAINA
2410 2420 2430 2440 2450
KQPVRLTDNS LRFAPVPMTK PILSSLPEVF SKHNGSAIPL GRFTFFKQLD
2460 2470 2480 2490 2500
LFLKRNKELT VQKIIFPLAH IQMLSDADAN KLWQYIFPLA WKILSSDNRS
2510 2520 2530 2540 2550
DLSKSLIYLL TRDYHIKQVN NRPNVISTLV SSFVKCAAKL ELPPHLVKYL
2560 2570 2580 2590 2600
GKLYGVYHES VSLLEIQLSD KYDMYQNAKV QESRADAVAE LYASLNEDDM
2610 2620 2630 2640 2650
FYGHWRRNCK YLQTQVALSY EQLGMWGRAQ QLYEQAQTKA RSEAIPFSES
2660 2670 2680 2690 2700
EYNLWEDQWV MCAQKLQQWD VLTELAKHEG SSELLLECAW RISDWSNNRE
2710 2720 2730 2740 2750
SLEVAIKSLS DVPTPRKLTF QCFMTLQKSV SQPLAIKEFQ QVLSEAIQLA
2760 2770 2780 2790 2800
LIKWHQLPEK VNQSHYSLLH LFQQFVELQE AATIYSHLNA INFQNLPTNV
2810 2820 2830 2840 2850
QLIKSALQVW QERLPNVWDD INLWRDLISW RQIVFSMINR VYLPLVPTIQ
2860 2870 2880 2890 2900
ANSSADSSNP PNTSFLFRGY HETAWLINRF AHVARKHKLP SVCLNQLTKI
2910 2920 2930 2940 2950
YTLPNIEIQE AFYKLREQVL CYLQNPRDLK TGLEVVTNTN LMYFNSRQKS
2960 2970 2980 2990 3000
EFVTLKGKFL EKLNRGEEAN QMYAAAVQID LGLPKAWAEW GRYNDLLFNK
3010 3020 3030 3040 3050
SPDNLSAACN AISCYLQAAG TYQSSKARKM LARVLWLLSL NDSAGTIVKA
3060 3070 3080 3090 3100
FESYKGDIPV WHWLTFIPQL LNSLSKGDTK CAPVVLKKIA KSYPQALFFT
3110 3120 3130 3140 3150
LRTAREDIAQ VKRTEMAAWK SNTTDENKRN EDILSIQSNF LSTNQSTNAP
3160 3170 3180 3190 3200
ATNKEDGLSK KVWEYIDEIM SILKTAYPLL ALTMETLVDQ IQAKFKCKND
3210 3220 3230 3240 3250
GDAFRLVVAL LNDAVQHSIR LGIVTDEMKL PSSTESNLSL FADNILPDYC
3260 3270 3280 3290 3300
KQLFKEDFIV NSNGLKSYIF KLRKWRSYFE RLLSKVPKKQ YLEQYSSFLC
3310 3320 3330 3340 3350
EFHHQKFDEI EVPGQYLLHK DNNNSFSCIE RFLPEVELIV GHGVCYRRLS
3360 3370 3380 3390 3400
IRSNGGTIHP FVIQYPSARN SRREERFMQL TRYLNDALAL NCETRRRCLK
3410 3420 3430 3440 3450
FYIPAVIPLS SHIRLLEDQP SSITLQKIYE IYSERNNFSR DDPKELFTNE
3460 3470 3480 3490 3500
LSKHMMELNS QISQESTDAE KLANRKQLFS RRIGMFENIQ KLYSPSTILK
3510 3520 3530 3540 3550
DYFSSIFTNY SDLWLFRKNF SYQYACFSFI TYILSINNRI PAKLVFSRDS
3560 3570 3580 3590 3600
GGVWTTEALP SMVSSTPVYH NGEIVPFRFT PNIKEFIGKT CTEGLLGPSI
3610 3620 3630 3640 3650
MAIARALSKP DFDLDMYLGI FIRDDLFWWL AQQTKGVPAD FSMLNKVNSN
3660 3670 3680 3690
TDLIMRRVAS LSQVAYGNLP VNQTAIDYLA QASSSKVLAQ MDVLWAPWL
Length:3,699
Mass (Da):422,339
Last modified:March 1, 2001 - v1
Checksum:i1B5810C719C89BAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAC08542.1.
RefSeqiNP_595777.1. NM_001021677.2.

Genome annotation databases

EnsemblFungiiSPBP16F5.03c.1; SPBP16F5.03c.1:pep; SPBP16F5.03c.
GeneIDi2541265.
KEGGispo:SPBP16F5.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAC08542.1.
RefSeqiNP_595777.1. NM_001021677.2.

3D structure databases

ProteinModelPortaliQ9HFE8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277779. 33 interactions.
IntActiQ9HFE8. 24 interactions.
MINTiMINT-8210490.

Proteomic databases

MaxQBiQ9HFE8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBP16F5.03c.1; SPBP16F5.03c.1:pep; SPBP16F5.03c.
GeneIDi2541265.
KEGGispo:SPBP16F5.03c.

Organism-specific databases

EuPathDBiFungiDB:SPBP16F5.03c.
PomBaseiSPBP16F5.03c. tra1.

Phylogenomic databases

HOGENOMiHOG000160814.
InParanoidiQ9HFE8.
KOiK08874.
OMAiERSQNIK.
OrthoDBiEOG7PCJR4.
PhylomeDBiQ9HFE8.

Miscellaneous databases

NextBioi20802377.
PROiQ9HFE8.

Family and domain databases

Gene3Di1.10.1070.11. 2 hits.
1.25.10.10. 4 hits.
1.25.40.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR011990. TPR-like_helical_dom.
IPR033317. TRA1/TRRAP.
[Graphical view]
PANTHERiPTHR11139:SF1. PTHR11139:SF1. 6 hits.
PfamiPF02259. FAT. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 13 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiTRA1_SCHPO
AccessioniPrimary (citable) accession number: Q9HFE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Although strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, suggesting that it may lack such activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.