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Protein

Calpain-like protease palB/RIM13

Gene

RIM13

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei158 – 1581PROSITE-ProRule annotation
Active sitei326 – 3261PROSITE-ProRule annotation
Active sitei362 – 3621PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-like protease palB/RIM13 (EC:3.4.22.-)
Alternative name(s):
Cysteine protease RIM13
Gene namesi
Name:RIM13
Ordered Locus Names:YALI0D14740g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome D

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 795795Calpain-like protease palB/RIM13PRO_0000207745Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9HFC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 408320Calpain catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 calpain catalytic domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ9HFC8.
OrthoDBiEOG74R21M.

Family and domain databases

InterProiIPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF00648. Peptidase_C2. 1 hit.
[Graphical view]
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HFC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPEEIYTS AMLAIACNDD KKAQEILVSL LQTYPDLVDY AKSISPATGK
60 70 80 90 100
LVLRQAKRSM DAYDSIKKGG SVLSLAEKIV YLSSRTNYGY ALPWEYATPV
110 120 130 140 150
SALKKSDDLY VDATDGGLRQ SQHRDVSWLR IPHVFASSDA VFTWSGFETL
160 170 180 190 200
YQDGLENCSF VASLLSIGVM EKRCNYSLLK EALLDKSSNH HLGTPPSSGR
210 220 230 240 250
YDIKLFINGC DRRITIDDRF PIREPSLPNM YLRSYTNPTL VWPALLEKAF
260 270 280 290 300
MKVLDGYDYA GSHAGGDTFV LCKWFPEFVS LTSYHDTNGL WRYIYDSWLQ
310 320 330 340 350
GDVLLCLGTG SFSREEADYK GLLGEHDYAV LELREIQDGC NTAHILRIRD
360 370 380 390 400
PLLFGPFSNP KNPLVEESNR LAKLVDGKNV DMASRGEIWM DFNQATREYQ
410 420 430 440 450
SLYLNWRPER FFCRLEQHFF WKTSDIMDFQ MCGSFVQNPQ YTITNNGTKT
460 470 480 490 500
ATGKLVLLRH TQGRETDAKS FCCIHLFEGA TRVVLQETSH AVYKGKLMNL
510 520 530 540 550
HYYTVSLTLK PGESTTAVMA CSGMTDSEPM YRFSLFLYAN NPLTMSKPTA
560 570 580 590 600
PLAYSQIFKG KWSEDQAGGN WAKPMYIHNP QFLLTVNEHC DQLYIYLTSS
610 620 630 640 650
SRQPIAAQLF WGSKSLKEYK ESAIETSSGK YKTGSTHLKT RNIDAGSNLI
660 670 680 690 700
LIISTFDSAP QTDYNIRVFS SGNFSLTQLA RHTAGKFTKS HKSKFYNSCS
710 720 730 740 750
EQVEFSVQQS TQHLSLAARM IKTRPFIRLT IREAQSNTVV ATTNTFSDSI
760 770 780 790
YGVHLDGVRV SRGLVYLAVI EKMEHSNNEP YVMEFAADTL VTLGH
Length:795
Mass (Da):89,799
Last modified:March 1, 2001 - v1
Checksum:iB29D4B04526227DC
GO

Sequence cautioni

The sequence CAG81021.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277150 Genomic DNA. Translation: CAC14603.1.
CR382130 Genomic DNA. Translation: CAG81021.1. Different initiation.
RefSeqiXP_502833.1. XM_502833.1.

Genome annotation databases

GeneIDi2910310.
KEGGiyli:YALI0D14740g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277150 Genomic DNA. Translation: CAC14603.1.
CR382130 Genomic DNA. Translation: CAG81021.1. Different initiation.
RefSeqiXP_502833.1. XM_502833.1.

3D structure databases

ProteinModelPortaliQ9HFC8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2910310.
KEGGiyli:YALI0D14740g.

Phylogenomic databases

InParanoidiQ9HFC8.
OrthoDBiEOG74R21M.

Family and domain databases

InterProiIPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF00648. Peptidase_C2. 1 hit.
[Graphical view]
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic control of extracellular protease synthesis in the yeast Yarrowia lipolytica."
    Gonzalez-Lopez C.I., Szabo R., Blanchin-Roland S., Gaillardin C.
    Genetics 160:417-427(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIB 122 / E 150.

Entry informationi

Entry nameiPALB_YARLI
AccessioniPrimary (citable) accession number: Q9HFC8
Secondary accession number(s): Q6C929
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.