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Reviewed, UniProtKB/Swiss-Prot Q9HEW1 (KAPR_CANAL)

Last modified November 24, 2009. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    cAMP-dependent protein kinase regulatory subunit
      Short name=PKA regulatory subunit
      Short name=PKA-R
Gene names
Name: BCY1
Synonyms: PKAR
ORF Names: CaO19.9565
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

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Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Subunit structure

Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer By similarity.

Sequence similarities

Belongs to the cAMP-dependent kinase regulatory chain family.

Contains 2 cyclic nucleotide-binding domains.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459cAMP-dependent protein kinase regulatory subunit
PRO_0000205404

Regions

Nucleotide binding220 – 335116cAMP 1
Nucleotide binding338 – 454117cAMP 2
Region30 – 219190Dimerization and phosphorylation Potential

Sites

Binding site2851cAMP 1 By similarity
Binding site2941cAMP 1 By similarity
Binding site4041cAMP 2 By similarity
Binding site4131cAMP 2 By similarity

Amino acid modifications

Modified residue1801Phosphoserine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9HEW1-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 68E22227601A1060

FASTA45950,306
        10         20         30         40         50         60 
MSNPQQQFIS DELSQLQKEI ISKNPQDVLQ FCANYFNTKL QAQRSELWSQ QAKAEAAGID 

        70         80         90        100        110        120 
LFPSVDHVNV NSSGVSIVND RQPSFKSPFG VNDPHSNHDE DPHAKDTKTD TAAAAVGGGI 

       130        140        150        160        170        180 
FKSNFDVKKS ASNPPTKEVD PDDPSKPSSS SQPNQQSASA SSKTPSSKIP VAFNANRRTS 

       190        200        210        220        230        240 
VSAEALNPAK LKLDSWKPPV NNLSITEEET LANNLKNNFL FKQLDANSKK TVIAALQQKS 

       250        260        270        280        290        300 
FAKDTVIIQQ GDEGDFFYII ETGTVDFYVN DAKVSSSSEG SSFGELALMY NSPRAATAVA 

       310        320        330        340        350        360 
ATDVVCWALD RLTFRRILLE GTFNKRLMYE DFLKDIEVLK SLSDHARSKL ADALSTEMYH 

       370        380        390        400        410        420 
KGDKIVTEGE QGENFYLIES GNCQVYNEKL GNIKQLTKGD YFGELALIKD LPRQATVEAL 

       430        440        450 
DNVIVATLGK SGFQRLLGPV VEVLKEQDPT KSQDPTAGH

« Hide

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References

« Hide 'large scale' references
[1]"Candida albicans lacking the gene encoding the regulatory subunit of protein kinase A displays a defect in hyphal formation and an altered localization of the catalytic subunit."
Cassola A., Parrot M., Silberstein S., Magee B.B., Passeron S., Giasson L., Cantore M.L.
Eukaryot. Cell 3:190-199(2004) [PubMed: 14871949] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CAI4.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314.

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Cross-references

Sequence databases

AF317472 Genomic DNA. Translation: AAG38599.1.
AACQ01000030 Genomic DNA. Translation: EAL00712.1.
RefSeqXP_719591.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3638765.
KEGGcal:CaO19.9565.

Organism-specific databases

CGDCAL0069592. BCY1.

Phylogenomic databases

OMAILLEGTF.
OrthoDBEOG9DRBW4.

Family and domain databases

InterProIPR003117. cAMP-dep_prot_kin_reg_I/II_a/b.
IPR002373. cAMP/cGMP_kin.
IPR000595. cNMP_bd.
IPR018490. cNMP_bd-like.
IPR018488. cNMP_bd_CS.
IPR012198. PK_regulatory.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
Gene3DG3DSA:2.60.120.10. RmlC-like_jellyroll. 2 hits.
PfamPF00027. cNMP_binding. 2 hits.
PF02197. RIIa. 1 hit.
[Graphical view]
PIRSFPIRSF000548. PK_regulatory. 1 hit.
PRINTSPR00103. CAMPKINASE.
SMARTSM00100. cNMP. 2 hits.
[Graphical view]
PROSITEPS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameKAPR_CANAL
AccessionPrimary (citable) accession number: Q9HEW1
Secondary accession number(s): Q5ADI2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: March 1, 2001
Last modified: November 24, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

Candida albicans

Candida albicans: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents