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Protein

Regulator of nonsense transcripts 1 homolog

Gene

2E4.130

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Eliminates the production of nonsense-containing RNAs.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei460 – 4601ATPBy similarity
Binding sitei650 – 6501ATPBy similarity
Binding sitei687 – 6871ATPBy similarity
Binding sitei818 – 8181ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri101 – 251151UPF1-typeAdd
BLAST
Nucleotide bindingi480 – 4845ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Nonsense-mediated mRNA decay

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of nonsense transcripts 1 homolog (EC:3.6.4.-)
Gene namesi
ORF Names:2E4.130, NCU04242
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 2, Linkage Group V

Organism-specific databases

EuPathDBiFungiDB:NCU04242.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10931093Regulator of nonsense transcripts 1 homologPRO_0000080714Add
BLAST

Proteomic databases

PRIDEiQ9HEH1.

Structurei

3D structure databases

ProteinModelPortaliQ9HEH1.
SMRiQ9HEH1. Positions 98-251, 272-892.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 624Poly-Asp
Compositional biasi69 – 735Poly-Asp

Sequence similaritiesi

Belongs to the DNA2/NAM7 helicase family.Curated
Contains 1 UPF1-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri101 – 251151UPF1-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000205990.
InParanoidiQ9HEH1.
KOiK14326.
OMAiHDSIGYI.
OrthoDBiEOG70PC5T.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR018999. RNA-helicase_UPF1_UPF2-interct.
[Graphical view]
PfamiPF09416. UPF1_Zn_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HEH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANMEVSFTH LGNHLVSDSA AAIKAGGSDE LSNIDPDENL LYGVYGGRGP
60 70 80 90 100
RGNGRRRHDD DDNETEVLDD DDDESLASVP VDGMKSLKLD APVEEKELPP
110 120 130 140 150
HACAYCGIHS PSSVVKCLTC NKWFCSAKGS AFSSHIVNHL VRARHKEVQL
160 170 180 190 200
HPESSLGDTV LECYNCGTKN VFILGFIPAK SDTVVVLLCR QPCGASTSTK
210 220 230 240 250
DMSWDISRWQ PLIEDRAFLN WLVTPPTDAE QLRARHLTPP MIAKLEEMWK
260 270 280 290 300
EAPNATVADL EKTAGVDDDP HPVLLKYDDP YHYQNIFGPL VKMESDYDKK
310 320 330 340 350
LKEAQSEDGL QVRWHLGLNS KHVASFILPK IESGDVKLAV GDEMRLKYKG
360 370 380 390 400
ELRPPWEGVG YVIKIPNNQS DEVEVELRKS ANDKSVPTEC THNFSADYVW
410 420 430 440 450
KATSYDRMQL AMKTFAVDEM SVSGYIFHKL LGHEVQVAPT KITMPKKFHV
460 470 480 490 500
PGLPELNASQ IAAIKQVLSN PLSLIQGPPG TGKTVTSATI IYHLAKMSNS
510 520 530 540 550
QVLVCAPSNV AVDQLCERIH RTGLKVVRLT AKSREDVESS VSFLALHEQV
560 570 580 590 600
RMNTTNKELD GLVKLKTETG ELSSQDEKRF KQLTRQAERE ILQNADVVCC
610 620 630 640 650
TCVGAGDPRL SKMKFRNVLI DESTQSAEPE CMIPLVLGCK QVVLVGDHKQ
660 670 680 690 700
LGPVIMNKKA AKAGLNQSLF ERLVKLQFTP IRLKVQYRMH PCLSEFPSNM
710 720 730 740 750
FYEGSLQNGV TAAERLRKDV DFPWPVPETP MMFWSNLGNE EISASGTSYL
760 770 780 790 800
NRTEAANVEK IVTRFFKAGV KPADIGVITP YEGQRSYIVN TMQNTGTFKK
810 820 830 840 850
ESYREVEVAS VDAFQGREKD FIVLSCVRSN ENQGIGFLSD PRRLNVALTR
860 870 880 890 900
AKYGLVIIGN PKVLCKHELW HHLLVHFKDK KCLVEGPLTN LQPSLLQFGR
910 920 930 940 950
PRQAYRPQRS HTQHVASGPS NGRFAAPLTA GSVRDYETGS MVSYIPDDVS
960 970 980 990 1000
SIHSSALGGA ALSSGYPAMF SNFHPEAWAG LPCAGPNGRP GAKGRGRATE
1010 1020 1030 1040 1050
SIAGESVANS EFTDATSSVI GGKGIGQGGA SLGAGLSEAI GSARPTSYSQ
1060 1070 1080 1090
SDRLKQYVES NGRMGVGNGY RRYDDDEKSV STAFASQIGT GFD
Length:1,093
Mass (Da):120,088
Last modified:March 1, 2001 - v1
Checksum:i8B0E4F0407ACE142
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL451022 Genomic DNA. Translation: CAC18314.1.
CM002240 Genomic DNA. Translation: EAA31997.1.
RefSeqiXP_961233.1. XM_956140.2.

Genome annotation databases

EnsemblFungiiEFNCRT00000003901; EFNCRP00000003901; EFNCRG00000003896.
GeneIDi3877396.
KEGGincr:NCU04242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL451022 Genomic DNA. Translation: CAC18314.1.
CM002240 Genomic DNA. Translation: EAA31997.1.
RefSeqiXP_961233.1. XM_956140.2.

3D structure databases

ProteinModelPortaliQ9HEH1.
SMRiQ9HEH1. Positions 98-251, 272-892.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9HEH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000003901; EFNCRP00000003901; EFNCRG00000003896.
GeneIDi3877396.
KEGGincr:NCU04242.

Organism-specific databases

EuPathDBiFungiDB:NCU04242.

Phylogenomic databases

HOGENOMiHOG000205990.
InParanoidiQ9HEH1.
KOiK14326.
OMAiHDSIGYI.
OrthoDBiEOG70PC5T.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR018999. RNA-helicase_UPF1_UPF2-interct.
[Graphical view]
PfamiPF09416. UPF1_Zn_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiRENT1_NEUCR
AccessioniPrimary (citable) accession number: Q9HEH1
Secondary accession number(s): Q7RVU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.