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Protein

DSC E3 ubiquitin ligase complex subunit 3

Gene

dsc3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • positive regulation of cellular response to hypoxia Source: PomBase
  • protein localization to Golgi apparatus Source: PomBase
  • protein processing Source: PomBase
  • protein ubiquitination Source: UniProtKB-UniPathway
  • regulation of protein glycosylation Source: PomBase
  • sterol regulatory element binding protein cleavage Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
DSC E3 ubiquitin ligase complex subunit 3
Alternative name(s):
Defective for SREBP cleavage protein 3
Gene namesi
Name:dsc3
ORF Names:SPAC20H4.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC20H4.02.
PomBaseiSPAC20H4.02. dsc3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • Dsc E3 ubiquitin ligase complex Source: PomBase
  • endoplasmic reticulum Source: PomBase
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003507551 – 250DSC E3 ubiquitin ligase complex subunit 3Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9HE10.

Interactioni

Subunit structurei

Component of the DSC E3 ubiquitin ligase complex composed of dsc1, dsc2, dsc3 and dsc4.1 Publication

Protein-protein interaction databases

BioGridi278474. 318 interactors.
MINTiMINT-4702971.

Family & Domainsi

Sequence similaritiesi

Belongs to the dsc3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ9HE10.
OMAiQLEERWI.
OrthoDBiEOG092C440X.
PhylomeDBiQ9HE10.

Family and domain databases

InterProiIPR025390. DUF2407_C.
IPR019413. DUF2407_N.
[Graphical view]
PfamiPF10302. DUF2407. 1 hit.
PF13373. DUF2407_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HE10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSALKKWE IVIRFASSIP DLSLEISDAQ TTTIHSLFKI VRNRIPECRD
60 70 80 90 100
KQLKMVFQGR LLSPGFTVER AVRGNWQRDE NDDPNIVQKA FIHCIVGPTL
110 120 130 140 150
TEEELASQDQ AQSGLNSNSE SPDDLQNAQT GETLRGFDRL REAGFTETEV
160 170 180 190 200
NNLRSQFHRL RGTNLDSLTE DAIREAEDDW IDNGGQNSSA DELDMSYETL
210 220 230 240 250
LAGVLIGFFG GAIACYFLWE RTMFSLRMQL SILVGIICNF AYGLLHSYRW
Length:250
Mass (Da):28,263
Last modified:March 1, 2001 - v1
Checksum:i1AD18FD0D28F3E63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAC19732.1.
RefSeqiNP_593622.1. NM_001019053.2.

Genome annotation databases

EnsemblFungiiSPAC20H4.02.1; SPAC20H4.02.1:pep; SPAC20H4.02.
GeneIDi2541990.
KEGGispo:SPAC20H4.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAC19732.1.
RefSeqiNP_593622.1. NM_001019053.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278474. 318 interactors.
MINTiMINT-4702971.

Proteomic databases

PRIDEiQ9HE10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC20H4.02.1; SPAC20H4.02.1:pep; SPAC20H4.02.
GeneIDi2541990.
KEGGispo:SPAC20H4.02.

Organism-specific databases

EuPathDBiFungiDB:SPAC20H4.02.
PomBaseiSPAC20H4.02. dsc3.

Phylogenomic databases

InParanoidiQ9HE10.
OMAiQLEERWI.
OrthoDBiEOG092C440X.
PhylomeDBiQ9HE10.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ9HE10.

Family and domain databases

InterProiIPR025390. DUF2407_C.
IPR019413. DUF2407_N.
[Graphical view]
PfamiPF10302. DUF2407. 1 hit.
PF13373. DUF2407_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDSC3_SCHPO
AccessioniPrimary (citable) accession number: Q9HE10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: March 1, 2001
Last modified: October 5, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.